以肉毒桿菌素治療戊二酸血症病童引起呼吸衰竭之照護

Translated title of the contribution: Care of a Child with Respiratory Failure due to Type 1 Glutaric Aciduria Treating by Botulin

鄭 淑娟(Shu-Chun Cheng), 鄭 淑華(Shu-Hua Cheng), 蘇 靖雅(Ching-Ya Su), 邊 苗瑛(Mauo-Ying Bien), 謝 慧觀(Huei-Guan Shie)

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: An outline of this rare but important disease, Glutaric aciduria type I is an inborn error of metabolism due to the deficiency of glutaryl-CoA dehydrogenase. The most important neurological symptoms include dyskinesia and dystonia, which can be focal, segmental or generalized. Treatment of the extrapyramidal syndrome is often unsatisfactory. OBJECTIVE: The objective was to describe a case of an Glutaric aciduria type I in the treatment of generalized and focal dystonia with botulinum toxin type A, but induced complication of respiratory failure. METHODS AND MATERIALS: We present a 4-year-old boy who developed respiratory failure after the fourth injection series by botulinum toxin type A. Sixty units of toxin was injected at each series and the intertreatment interval was six months. RESULTS: This ventilatory dependent case was ventilatory muscle weakness and frequency aspiration pneumonia after injection of botulinum toxin type A. CONCLUSION: Our case alerts with the expanding use of botulinum toxin, much concern about the botulinum toxin is arising.
Translated title of the contributionCare of a Child with Respiratory Failure due to Type 1 Glutaric Aciduria Treating by Botulin
Original languageChinese (Traditional)
Pages (from-to)81-95
Number of pages15
Journal呼吸治療
Volume7
Issue number1
DOIs
Publication statusPublished - 2008

Keywords

  • complication
  • respiratory failure
  • botulinum toxin type A
  • Type 1 Glutaric Aciduria

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