以肉毒桿菌素治療戊二酸血症病童引起呼吸衰竭之照護

Translated title of the contribution: Care of a Child with Respiratory Failure due to Type 1 Glutaric Aciduria Treating by Botulin

鄭 淑娟(Shu-Chun Cheng), 鄭 淑華(Shu-Hua Cheng), 蘇 靖雅(Ching-Ya Su), 邊 苗瑛(Mauo-Ying Bien), 謝 慧觀(Huei-Guan Shie)

Research output: Contribution to journalArticle

Abstract

BACKGROUND: An outline of this rare but important disease, Glutaric aciduria type I is an inborn error of metabolism due to the deficiency of glutaryl-CoA dehydrogenase. The most important neurological symptoms include dyskinesia and dystonia, which can be focal, segmental or generalized. Treatment of the extrapyramidal syndrome is often unsatisfactory. OBJECTIVE: The objective was to describe a case of an Glutaric aciduria type I in the treatment of generalized and focal dystonia with botulinum toxin type A, but induced complication of respiratory failure. METHODS AND MATERIALS: We present a 4-year-old boy who developed respiratory failure after the fourth injection series by botulinum toxin type A. Sixty units of toxin was injected at each series and the intertreatment interval was six months. RESULTS: This ventilatory dependent case was ventilatory muscle weakness and frequency aspiration pneumonia after injection of botulinum toxin type A. CONCLUSION: Our case alerts with the expanding use of botulinum toxin, much concern about the botulinum toxin is arising.
Original languageTraditional Chinese
Pages (from-to)81-95
Number of pages15
Journal呼吸治療
Volume7
Issue number1
DOIs
Publication statusPublished - 2008

Fingerprint

Type A Botulinum Toxins
Botulinum Toxins
Child Care
Respiratory Insufficiency
Dystonic Disorders
Aspiration Pneumonia
Inborn Errors Metabolism
Injections
Respiratory Muscles
Dystonia
Muscle Weakness
Dyskinesias
Rare Diseases
Therapeutics
Glutaric Acidemia I

Keywords

  • complication
  • respiratory failure
  • botulinum toxin type A
  • Type 1 Glutaric Aciduria

Cite this

鄭淑娟(Shu-Chun C, 鄭淑華(Shu-Hua C, 蘇靖雅(Ching-Ya S, 邊苗瑛(Mauo-Ying B, & 謝慧觀(Huei-Guan S (2008). 以肉毒桿菌素治療戊二酸血症病童引起呼吸衰竭之照護. 呼吸治療, 7(1), 81-95. https://doi.org/10.6269/JRT.2008.7.1.07

以肉毒桿菌素治療戊二酸血症病童引起呼吸衰竭之照護. / 鄭淑娟(Shu-Chun Cheng); 鄭淑華(Shu-Hua Cheng); 蘇靖雅(Ching-Ya Su); 邊苗瑛(Mauo-Ying Bien); 謝慧觀(Huei-Guan Shie).

In: 呼吸治療, Vol. 7, No. 1, 2008, p. 81-95.

Research output: Contribution to journalArticle

鄭淑娟(Shu-ChunC, 鄭淑華(Shu-HuaC, 蘇靖雅(Ching-YaS, 邊苗瑛(Mauo-YingB & 謝慧觀(Huei-GuanS 2008, '以肉毒桿菌素治療戊二酸血症病童引起呼吸衰竭之照護', 呼吸治療, vol. 7, no. 1, pp. 81-95. https://doi.org/10.6269/JRT.2008.7.1.07
鄭淑娟(Shu-ChunC, 鄭淑華(Shu-HuaC, 蘇靖雅(Ching-YaS, 邊苗瑛(Mauo-YingB, 謝慧觀(Huei-GuanS. 以肉毒桿菌素治療戊二酸血症病童引起呼吸衰竭之照護. 呼吸治療. 2008;7(1):81-95. https://doi.org/10.6269/JRT.2008.7.1.07
鄭淑娟(Shu-Chun Cheng) ; 鄭淑華(Shu-Hua Cheng) ; 蘇靖雅(Ching-Ya Su) ; 邊苗瑛(Mauo-Ying Bien) ; 謝慧觀(Huei-Guan Shie). / 以肉毒桿菌素治療戊二酸血症病童引起呼吸衰竭之照護. In: 呼吸治療. 2008 ; Vol. 7, No. 1. pp. 81-95.
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title = "以肉毒桿菌素治療戊二酸血症病童引起呼吸衰竭之照護",
abstract = "戊二酸血症第一型是出生時戊二基輔酶A去氫酶基因(Glutaryl-CoA Dehydrogenase)代謝異常,一種罕見且重要的疾病,最重要的神經症狀包括點、局部或全身的運動障礙與肌肉低張力,治療這些錐體外路症候群,結果通常無法令人滿意,個案係罹患第一型戊二酸血症,以A型肉毒桿菌素治療錐體外路症候群,卻引發呼吸衰竭的合併症。此四歲兒童於每隔六個月注射A型肉毒桿菌素,四次療程後產生呼吸衰竭,主要因呼吸肌肉無力與反覆性吸入性肺炎所引發呼吸衰竭,終至必須長期依賴呼吸器,此類個案以A型肉毒桿菌素治療錐體外路症候群,必須小心注意毒素蓄積的問題。",
keywords = "第一型戊二酸血症, A型肉毒桿菌素, 呼吸衰竭, 合併症, complication, respiratory failure , botulinum toxin type A , Type 1 Glutaric Aciduria",
author = "鄭, {淑娟(Shu-Chun Cheng)} and 鄭, {淑華(Shu-Hua Cheng)} and 蘇, {靖雅(Ching-Ya Su)} and 邊, {苗瑛(Mauo-Ying Bien)} and 謝, {慧觀(Huei-Guan Shie)}",
year = "2008",
doi = "10.6269/JRT.2008.7.1.07",
language = "繁體中文",
volume = "7",
pages = "81--95",
journal = "呼吸治療",
issn = "1991-2609",
publisher = "臺灣呼吸治療學會",
number = "1",

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AU - 鄭, 淑娟(Shu-Chun Cheng)

AU - 鄭, 淑華(Shu-Hua Cheng)

AU - 蘇, 靖雅(Ching-Ya Su)

AU - 邊, 苗瑛(Mauo-Ying Bien)

AU - 謝, 慧觀(Huei-Guan Shie)

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AB - 戊二酸血症第一型是出生時戊二基輔酶A去氫酶基因(Glutaryl-CoA Dehydrogenase)代謝異常,一種罕見且重要的疾病,最重要的神經症狀包括點、局部或全身的運動障礙與肌肉低張力,治療這些錐體外路症候群,結果通常無法令人滿意,個案係罹患第一型戊二酸血症,以A型肉毒桿菌素治療錐體外路症候群,卻引發呼吸衰竭的合併症。此四歲兒童於每隔六個月注射A型肉毒桿菌素,四次療程後產生呼吸衰竭,主要因呼吸肌肉無力與反覆性吸入性肺炎所引發呼吸衰竭,終至必須長期依賴呼吸器,此類個案以A型肉毒桿菌素治療錐體外路症候群,必須小心注意毒素蓄積的問題。

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KW - respiratory failure

KW - botulinum toxin type A

KW - Type 1 Glutaric Aciduria

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