Cardiovascular protection of magnolol

Cell-type specificity and dose-related effects

Jennifer Hui Chun Ho, Chuang Ye Hong

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Magnolia officinalis has been widely used in traditional Chinese medicine. Magnolol, an active component isolated from Magnolia officinalis, is known to be a cardiovascular protector since 1994. The multiplex mechanisms of magnolol on cardiovascular protection depends on cell types and dosages, and will be reviewed and discussed in this article. Magnolol under low and moderate dosage possesses the ability to protect heart from ischemic/ reperfusion injury, reduces atherosclerotic change, protects endothelial cell against apoptosis and inhibits neutrophil-endothelial adhesion. The moderate to high concentration of magnolol mainly acts on smooth muscle cells and platelets. Magnolol induces apoptosis in vascular smooth muscle cells at moderate concentration and inhibits proliferation at moderate and high concentration. High concentration of magnolol also abrogates platelet activation, aggregation and thrombus formation. Magnolol also serves as an smooth muscle relaxant only upon the high concentration. Oral intake of magnolol to reach the therapeutic level for cardiovascular protection is applicable, thus makes magnolol an agent of great potential for preventing cardiovascular diseases in high-risk patients.

Original languageEnglish
Article number70
JournalJournal of Biomedical Science
Volume19
Issue number1
DOIs
Publication statusPublished - 2012

Fingerprint

Cytoprotection
Magnolia
Muscle
Platelets
Smooth Muscle Myocytes
Cells
Apoptosis
magnolol
Endothelial cells
Chinese Traditional Medicine
Platelet Activation
Reperfusion Injury
Platelet Aggregation
Vascular Smooth Muscle
Medicine
Smooth Muscle
Neutrophils
Thrombosis
Cardiovascular Diseases
Blood Platelets

Keywords

  • Antioxidant
  • Cardiomyocytes
  • Inflammation
  • Magnolol
  • Smooth muscle cells
  • Vascular endothelial cells

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Molecular Biology
  • Cell Biology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism
  • Pharmacology (medical)

Cite this

Cardiovascular protection of magnolol : Cell-type specificity and dose-related effects. / Ho, Jennifer Hui Chun; Hong, Chuang Ye.

In: Journal of Biomedical Science, Vol. 19, No. 1, 70, 2012.

Research output: Contribution to journalArticle

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