Cardiotrophin-1 is inversely associated with obesity in non-diabetic individuals

Hao Chang Hung, Feng Hwa Lu, Hung Tsung Wu, Horng Yih Ou, Yi Ching Yang, Jin Shang Wu, Chih Jen Chang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Cardiotrophin-1 is known to be a key regulator of energy homeostasis, as well as glucose and lipid metabolism in vivo. However, there are inconsistent results of the association between cardiotrophin-1 and obesity in humans, possibly confounded by hyperglycemia. Therefore, the aim of this study was to investigate the relationships among cardiotrophin-1 levels, overweight and obese individuals without diabetes in a Chinese population. The median (inter-quarter range) serum cardiotrophin-1 levels were 447.9 (230.9, 913.9), 350.6 (201.1, 666.5), and 288.1 (162.3, 572.4) pg/ml in non-diabetic subjects who were of normal weight (n = 522), overweight (n = 203), and obese (n = 93), respectively (trend test p < 0.001). Subjects who were overweight and obese had significantly lower cardiotrophin-1 levels than those with normal weight. The multivariate linear regression analyses showed that overweight (beta =-338.718, 95% CI =-552.786 ∼-124.651, p < 0.01), obese (beta =-530.275, 95% CI =-832.967 ∼-227.583, p < 0.01), and smoking (beta =-377.375, 95% CI =-654.353 ∼-100.397, p < 0.01) were negatively related to cardiotrophin-1 after adjusting for age, gender, HOMA-IR, hypertension, total cholesterol, HDL, triglyceride, eGFR, ALT, and alcohol drinking. The results of this study provided epidemiological evidence that non-diabetic subjects who were overweight or obesity had significantly lower cardiotrophin-1 concentrations than those with normal weight, and both obesity and being overweight were inversely associated with cardiotrophin-1 levels.

Original languageEnglish
Article number17438
JournalScientific Reports
Volume5
DOIs
Publication statusPublished - Dec 1 2015
Externally publishedYes

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Obesity
Weights and Measures
cardiotrophin 1
Lipid Metabolism
Hyperglycemia
Alcohol Drinking
HDL Cholesterol
Epidemiologic Studies
Linear Models
Triglycerides
Homeostasis
Smoking
Regression Analysis
Hypertension
Glucose
Serum
Population

ASJC Scopus subject areas

  • General

Cite this

Hung, H. C., Lu, F. H., Wu, H. T., Ou, H. Y., Yang, Y. C., Wu, J. S., & Chang, C. J. (2015). Cardiotrophin-1 is inversely associated with obesity in non-diabetic individuals. Scientific Reports, 5, [17438]. https://doi.org/10.1038/srep17438

Cardiotrophin-1 is inversely associated with obesity in non-diabetic individuals. / Hung, Hao Chang; Lu, Feng Hwa; Wu, Hung Tsung; Ou, Horng Yih; Yang, Yi Ching; Wu, Jin Shang; Chang, Chih Jen.

In: Scientific Reports, Vol. 5, 17438, 01.12.2015.

Research output: Contribution to journalArticle

Hung, Hao Chang ; Lu, Feng Hwa ; Wu, Hung Tsung ; Ou, Horng Yih ; Yang, Yi Ching ; Wu, Jin Shang ; Chang, Chih Jen. / Cardiotrophin-1 is inversely associated with obesity in non-diabetic individuals. In: Scientific Reports. 2015 ; Vol. 5.
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