Cardiotrophin-1 is inversely associated with obesity in non-diabetic individuals

Hao Chang Hung, Feng Hwa Lu, Hung Tsung Wu, Horng Yih Ou, Yi Ching Yang, Jin Shang Wu, Chih Jen Chang

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Abstract

Cardiotrophin-1 is known to be a key regulator of energy homeostasis, as well as glucose and lipid metabolism in vivo. However, there are inconsistent results of the association between cardiotrophin-1 and obesity in humans, possibly confounded by hyperglycemia. Therefore, the aim of this study was to investigate the relationships among cardiotrophin-1 levels, overweight and obese individuals without diabetes in a Chinese population. The median (inter-quarter range) serum cardiotrophin-1 levels were 447.9 (230.9, 913.9), 350.6 (201.1, 666.5), and 288.1 (162.3, 572.4) pg/ml in non-diabetic subjects who were of normal weight (n = 522), overweight (n = 203), and obese (n = 93), respectively (trend test p < 0.001). Subjects who were overweight and obese had significantly lower cardiotrophin-1 levels than those with normal weight. The multivariate linear regression analyses showed that overweight (beta =-338.718, 95% CI =-552.786 ∼-124.651, p < 0.01), obese (beta =-530.275, 95% CI =-832.967 ∼-227.583, p < 0.01), and smoking (beta =-377.375, 95% CI =-654.353 ∼-100.397, p < 0.01) were negatively related to cardiotrophin-1 after adjusting for age, gender, HOMA-IR, hypertension, total cholesterol, HDL, triglyceride, eGFR, ALT, and alcohol drinking. The results of this study provided epidemiological evidence that non-diabetic subjects who were overweight or obesity had significantly lower cardiotrophin-1 concentrations than those with normal weight, and both obesity and being overweight were inversely associated with cardiotrophin-1 levels.

Original languageEnglish
Article number17438
JournalScientific Reports
Volume5
DOIs
Publication statusPublished - Dec 1 2015
Externally publishedYes

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    Hung, H. C., Lu, F. H., Wu, H. T., Ou, H. Y., Yang, Y. C., Wu, J. S., & Chang, C. J. (2015). Cardiotrophin-1 is inversely associated with obesity in non-diabetic individuals. Scientific Reports, 5, [17438]. https://doi.org/10.1038/srep17438