Cardiotrophin-1 is associated with increased risk of arterial stiffness

Hao Chang Hung, Feng Hwa Lu, Horng Yih Ou, Hung Tsung Wu, Jin Shang Wu, Yi Ching Yang, Chih Jen Chang

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Aim: Cardiotrophin-1 null mice presented decreased arterial stiffness. The aim of this study is to investigate the relationship between cardiotrophin-1 and arterial stiffness, assessed by brachial-ankle pulse-wave velocity (baPWV). Methods: We enrolled 300 subjects, 200 with baPWV >1400 and 100 with baPWV ≤1400 cm/s. Results: Cardiotrophin-1 levels were significantly higher in subjects with baPWV >1400 than those with baPWV ≤1400 cm/s. The multivariate logistic regression analysis showed that age, prehypertension, hypertension and cardiotrophin-1 were independently associated with baPWV >1400 cm/s after adjusting for gender, obesity, diabetes, homeostasis model assessment-insulin resistance, total cholesterol, high-density lipoprotein cholesterol, triglyceride, high-sensitivity C-reactive protein, creatinine, smoking and habitual exercise. Conclusion: Cardiotrophin-1 is positively related to baPWV independent of traditional cardiometabolic risk factors for arterial stiffness.

Original languageEnglish
Pages (from-to)123-130
Number of pages8
JournalBiomarkers in Medicine
Volume9
Issue number2
DOIs
Publication statusPublished - Feb 1 2015
Externally publishedYes

Fingerprint

Pulse Wave Analysis
Vascular Stiffness
Ankle
Arm
Stiffness
Prehypertension
Cholesterol
Medical problems
cardiotrophin 1
Regression analysis
C-Reactive Protein
HDL Cholesterol
Insulin Resistance
Logistics
Creatinine
Triglycerides
Homeostasis
Obesity
Logistic Models
Smoking

Keywords

  • Arterial stiffness
  • Brachial-ankle pulse-wave velocity
  • Cardiotrophin-1

ASJC Scopus subject areas

  • Drug Discovery
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Hung, H. C., Lu, F. H., Ou, H. Y., Wu, H. T., Wu, J. S., Yang, Y. C., & Chang, C. J. (2015). Cardiotrophin-1 is associated with increased risk of arterial stiffness. Biomarkers in Medicine, 9(2), 123-130. https://doi.org/10.2217/BMM.14.87

Cardiotrophin-1 is associated with increased risk of arterial stiffness. / Hung, Hao Chang; Lu, Feng Hwa; Ou, Horng Yih; Wu, Hung Tsung; Wu, Jin Shang; Yang, Yi Ching; Chang, Chih Jen.

In: Biomarkers in Medicine, Vol. 9, No. 2, 01.02.2015, p. 123-130.

Research output: Contribution to journalArticle

Hung, HC, Lu, FH, Ou, HY, Wu, HT, Wu, JS, Yang, YC & Chang, CJ 2015, 'Cardiotrophin-1 is associated with increased risk of arterial stiffness', Biomarkers in Medicine, vol. 9, no. 2, pp. 123-130. https://doi.org/10.2217/BMM.14.87
Hung, Hao Chang ; Lu, Feng Hwa ; Ou, Horng Yih ; Wu, Hung Tsung ; Wu, Jin Shang ; Yang, Yi Ching ; Chang, Chih Jen. / Cardiotrophin-1 is associated with increased risk of arterial stiffness. In: Biomarkers in Medicine. 2015 ; Vol. 9, No. 2. pp. 123-130.
@article{a372e7d4f6f6450cbd0b2a4dd0376c90,
title = "Cardiotrophin-1 is associated with increased risk of arterial stiffness",
abstract = "Aim: Cardiotrophin-1 null mice presented decreased arterial stiffness. The aim of this study is to investigate the relationship between cardiotrophin-1 and arterial stiffness, assessed by brachial-ankle pulse-wave velocity (baPWV). Methods: We enrolled 300 subjects, 200 with baPWV >1400 and 100 with baPWV ≤1400 cm/s. Results: Cardiotrophin-1 levels were significantly higher in subjects with baPWV >1400 than those with baPWV ≤1400 cm/s. The multivariate logistic regression analysis showed that age, prehypertension, hypertension and cardiotrophin-1 were independently associated with baPWV >1400 cm/s after adjusting for gender, obesity, diabetes, homeostasis model assessment-insulin resistance, total cholesterol, high-density lipoprotein cholesterol, triglyceride, high-sensitivity C-reactive protein, creatinine, smoking and habitual exercise. Conclusion: Cardiotrophin-1 is positively related to baPWV independent of traditional cardiometabolic risk factors for arterial stiffness.",
keywords = "Arterial stiffness, Brachial-ankle pulse-wave velocity, Cardiotrophin-1",
author = "Hung, {Hao Chang} and Lu, {Feng Hwa} and Ou, {Horng Yih} and Wu, {Hung Tsung} and Wu, {Jin Shang} and Yang, {Yi Ching} and Chang, {Chih Jen}",
year = "2015",
month = "2",
day = "1",
doi = "10.2217/BMM.14.87",
language = "English",
volume = "9",
pages = "123--130",
journal = "Biomarkers in Medicine",
issn = "1752-0363",
publisher = "Future Medicine Ltd.",
number = "2",

}

TY - JOUR

T1 - Cardiotrophin-1 is associated with increased risk of arterial stiffness

AU - Hung, Hao Chang

AU - Lu, Feng Hwa

AU - Ou, Horng Yih

AU - Wu, Hung Tsung

AU - Wu, Jin Shang

AU - Yang, Yi Ching

AU - Chang, Chih Jen

PY - 2015/2/1

Y1 - 2015/2/1

N2 - Aim: Cardiotrophin-1 null mice presented decreased arterial stiffness. The aim of this study is to investigate the relationship between cardiotrophin-1 and arterial stiffness, assessed by brachial-ankle pulse-wave velocity (baPWV). Methods: We enrolled 300 subjects, 200 with baPWV >1400 and 100 with baPWV ≤1400 cm/s. Results: Cardiotrophin-1 levels were significantly higher in subjects with baPWV >1400 than those with baPWV ≤1400 cm/s. The multivariate logistic regression analysis showed that age, prehypertension, hypertension and cardiotrophin-1 were independently associated with baPWV >1400 cm/s after adjusting for gender, obesity, diabetes, homeostasis model assessment-insulin resistance, total cholesterol, high-density lipoprotein cholesterol, triglyceride, high-sensitivity C-reactive protein, creatinine, smoking and habitual exercise. Conclusion: Cardiotrophin-1 is positively related to baPWV independent of traditional cardiometabolic risk factors for arterial stiffness.

AB - Aim: Cardiotrophin-1 null mice presented decreased arterial stiffness. The aim of this study is to investigate the relationship between cardiotrophin-1 and arterial stiffness, assessed by brachial-ankle pulse-wave velocity (baPWV). Methods: We enrolled 300 subjects, 200 with baPWV >1400 and 100 with baPWV ≤1400 cm/s. Results: Cardiotrophin-1 levels were significantly higher in subjects with baPWV >1400 than those with baPWV ≤1400 cm/s. The multivariate logistic regression analysis showed that age, prehypertension, hypertension and cardiotrophin-1 were independently associated with baPWV >1400 cm/s after adjusting for gender, obesity, diabetes, homeostasis model assessment-insulin resistance, total cholesterol, high-density lipoprotein cholesterol, triglyceride, high-sensitivity C-reactive protein, creatinine, smoking and habitual exercise. Conclusion: Cardiotrophin-1 is positively related to baPWV independent of traditional cardiometabolic risk factors for arterial stiffness.

KW - Arterial stiffness

KW - Brachial-ankle pulse-wave velocity

KW - Cardiotrophin-1

UR - http://www.scopus.com/inward/record.url?scp=84923457688&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84923457688&partnerID=8YFLogxK

U2 - 10.2217/BMM.14.87

DO - 10.2217/BMM.14.87

M3 - Article

VL - 9

SP - 123

EP - 130

JO - Biomarkers in Medicine

JF - Biomarkers in Medicine

SN - 1752-0363

IS - 2

ER -