Cardiotrophin-1 is associated with increased risk of arterial stiffness

Hao Chang Hung, Feng Hwa Lu, Horng Yih Ou, Hung Tsung Wu, Jin Shang Wu, Yi Ching Yang, Chih Jen Chang

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Aim: Cardiotrophin-1 null mice presented decreased arterial stiffness. The aim of this study is to investigate the relationship between cardiotrophin-1 and arterial stiffness, assessed by brachial-ankle pulse-wave velocity (baPWV). Methods: We enrolled 300 subjects, 200 with baPWV >1400 and 100 with baPWV ≤1400 cm/s. Results: Cardiotrophin-1 levels were significantly higher in subjects with baPWV >1400 than those with baPWV ≤1400 cm/s. The multivariate logistic regression analysis showed that age, prehypertension, hypertension and cardiotrophin-1 were independently associated with baPWV >1400 cm/s after adjusting for gender, obesity, diabetes, homeostasis model assessment-insulin resistance, total cholesterol, high-density lipoprotein cholesterol, triglyceride, high-sensitivity C-reactive protein, creatinine, smoking and habitual exercise. Conclusion: Cardiotrophin-1 is positively related to baPWV independent of traditional cardiometabolic risk factors for arterial stiffness.

Original languageEnglish
Pages (from-to)123-130
Number of pages8
JournalBiomarkers in Medicine
Volume9
Issue number2
DOIs
Publication statusPublished - Feb 1 2015
Externally publishedYes

Keywords

  • Arterial stiffness
  • Brachial-ankle pulse-wave velocity
  • Cardiotrophin-1

ASJC Scopus subject areas

  • Drug Discovery
  • Clinical Biochemistry
  • Biochemistry, medical

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  • Cite this

    Hung, H. C., Lu, F. H., Ou, H. Y., Wu, H. T., Wu, J. S., Yang, Y. C., & Chang, C. J. (2015). Cardiotrophin-1 is associated with increased risk of arterial stiffness. Biomarkers in Medicine, 9(2), 123-130. https://doi.org/10.2217/BMM.14.87