Cardiotoxin III inhibits proliferation and migration of oral cancer cells through MAPK and MMP signaling

Ching Yu Yen, Shih Shin Liang, Lo Yi Han, Han Lin Chou, Chon Kit Chou, Shinne Ren Lin, Chien Chih Chiu

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Cardiotoxin III (CTXIII), isolated from the snake venom of Formosan cobra Naja naja atra, has previously been found to induce apoptosis in many types of cancer. Early metastasis is typical for the progression of oral cancer. To modulate the cell migration behavior of oral cancer is one of the oral cancer therapies. In this study, the possible modulating effect of CTXIII on oral cancer migration is addressed. In the example of oral squamous carcinoma Ca9-22 cells, the cell viability was decreased by CTXIII treatment in a dose-responsive manner. In wound-healing assay, the cell migration of Ca9-22 cells was attenuated by CTXIII in a dose- and time-responsive manner. After CTXIII treatment, the MMP-2 and MMP-9 protein expressions were downregulated, and the phosphorylation of JNK and p38-MAPK was increased independent of ERK phosphorylation. In conclusion, CTXIII has antiproliferative and -migrating effects on oral cancer cells involving the p38-MAPK and MMP-2/-9 pathways.

Original languageEnglish
Article number650946
JournalScientific World Journal
Volume2013
DOIs
Publication statusPublished - 2013

Fingerprint

Cardiotoxins
Mouth Neoplasms
Matrix Metalloproteinases
cancer
Cells
Elapidae
Phosphorylation
p38 Mitogen-Activated Protein Kinases
Cell Movement
venom
Snake Venoms
apoptosis
snake
Wound Healing
Squamous Cell Carcinoma
Assays
Cell Survival
viability
Down-Regulation
assay

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Medicine(all)

Cite this

Cardiotoxin III inhibits proliferation and migration of oral cancer cells through MAPK and MMP signaling. / Yen, Ching Yu; Liang, Shih Shin; Han, Lo Yi; Chou, Han Lin; Chou, Chon Kit; Lin, Shinne Ren; Chiu, Chien Chih.

In: Scientific World Journal, Vol. 2013, 650946, 2013.

Research output: Contribution to journalArticle

Yen, Ching Yu ; Liang, Shih Shin ; Han, Lo Yi ; Chou, Han Lin ; Chou, Chon Kit ; Lin, Shinne Ren ; Chiu, Chien Chih. / Cardiotoxin III inhibits proliferation and migration of oral cancer cells through MAPK and MMP signaling. In: Scientific World Journal. 2013 ; Vol. 2013.
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AU - Chou, Chon Kit

AU - Lin, Shinne Ren

AU - Chiu, Chien Chih

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