Cardiac myosin binding protein C and MAP-kinase activating death domain-containing gene polymorphisms and diastolic heart failure

Cho Kai Wu, Yin Tsen Huang, Jen Kuang Lee, Liang Ting Chiang, Fu Tien Chiang, Shu Wei Huang, Jiunn Lee Lin, Chuen Den Tseng, Yau Hung Chen, Chia Ti Tsai

Research output: Contribution to journalArticle

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Abstract

Objective: Myosin binding protein C (MYBPC3) plays a role in ventricular relaxation. The aim of the study was to investigate the association between cardiac myosin binding protein C (MYBPC3) gene polymorphisms and diastolic heart failure (DHF) in a human case-control study. Methods: A total of 352 participants of 1752 consecutive patients from the National Taiwan University Hospital and its affiliated hospital were enrolled. 176 patients diagnosed with DHF confirmed by echocardiography were recruited. Controls were matched 1-to-1 by age, sex, hypertension, diabetes, renal function and medication use. We genotyped 12 single nucleotide polymorphisms (SNPs) according to HapMap Han Chinese Beijing databank across a 40 kb genetic region containing the MYBPC3 gene and the neighboring DNA sequences to capture 100% of haplotype variance in all SNPs with minor allele frequencies ≥5%. We also analyzed associations of these tagging SNPs and haplotypes with DHF and linkage disequilibrium (LD) structure of the MYBPC3 gene. Results: In a single locus analysis, SNP rs2290149 was associated with DHF (allele-specific p = 0.004; permuted p = 0.031). The SNP with a minor allele frequency of 9.4%, had an odds ratio 2.14 (95% CI 1.25-3.66; p = 0.004) for the additive model and 2.06 for the autosomal dominant model (GG+GA: AA, 95% CI 1.17-3.63; p = 0.013), corresponding to a population attributable risk fraction of 12.02%. The haplotypes in a LD block of rs2290149 (C-C-G-C) was also significantly associated with DHF (odds ratio 2.10 (1.53-2.89); permuted p = 0.029). Conclusions: We identified a SNP (rs2290149) among the tagging SNP set that was significantly associated with early DHF in a Chinese population.

Original languageEnglish
Article numbere35242
JournalPLoS One
Volume7
Issue number4
DOIs
Publication statusPublished - Apr 17 2012
Externally publishedYes

Fingerprint

Diastolic Heart Failure
Cardiac Myosins
heart failure
myosin
Polymorphism
mitogen-activated protein kinase
single nucleotide polymorphism
Single Nucleotide Polymorphism
binding proteins
Phosphotransferases
Genes
genetic polymorphism
death
Nucleotides
Haplotypes
genes
haplotypes
Linkage Disequilibrium
linkage disequilibrium
Gene Frequency

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Wu, C. K., Huang, Y. T., Lee, J. K., Chiang, L. T., Chiang, F. T., Huang, S. W., ... Tsai, C. T. (2012). Cardiac myosin binding protein C and MAP-kinase activating death domain-containing gene polymorphisms and diastolic heart failure. PLoS One, 7(4), [e35242]. https://doi.org/10.1371/journal.pone.0035242

Cardiac myosin binding protein C and MAP-kinase activating death domain-containing gene polymorphisms and diastolic heart failure. / Wu, Cho Kai; Huang, Yin Tsen; Lee, Jen Kuang; Chiang, Liang Ting; Chiang, Fu Tien; Huang, Shu Wei; Lin, Jiunn Lee; Tseng, Chuen Den; Chen, Yau Hung; Tsai, Chia Ti.

In: PLoS One, Vol. 7, No. 4, e35242, 17.04.2012.

Research output: Contribution to journalArticle

Wu, CK, Huang, YT, Lee, JK, Chiang, LT, Chiang, FT, Huang, SW, Lin, JL, Tseng, CD, Chen, YH & Tsai, CT 2012, 'Cardiac myosin binding protein C and MAP-kinase activating death domain-containing gene polymorphisms and diastolic heart failure', PLoS One, vol. 7, no. 4, e35242. https://doi.org/10.1371/journal.pone.0035242
Wu, Cho Kai ; Huang, Yin Tsen ; Lee, Jen Kuang ; Chiang, Liang Ting ; Chiang, Fu Tien ; Huang, Shu Wei ; Lin, Jiunn Lee ; Tseng, Chuen Den ; Chen, Yau Hung ; Tsai, Chia Ti. / Cardiac myosin binding protein C and MAP-kinase activating death domain-containing gene polymorphisms and diastolic heart failure. In: PLoS One. 2012 ; Vol. 7, No. 4.
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abstract = "Objective: Myosin binding protein C (MYBPC3) plays a role in ventricular relaxation. The aim of the study was to investigate the association between cardiac myosin binding protein C (MYBPC3) gene polymorphisms and diastolic heart failure (DHF) in a human case-control study. Methods: A total of 352 participants of 1752 consecutive patients from the National Taiwan University Hospital and its affiliated hospital were enrolled. 176 patients diagnosed with DHF confirmed by echocardiography were recruited. Controls were matched 1-to-1 by age, sex, hypertension, diabetes, renal function and medication use. We genotyped 12 single nucleotide polymorphisms (SNPs) according to HapMap Han Chinese Beijing databank across a 40 kb genetic region containing the MYBPC3 gene and the neighboring DNA sequences to capture 100{\%} of haplotype variance in all SNPs with minor allele frequencies ≥5{\%}. We also analyzed associations of these tagging SNPs and haplotypes with DHF and linkage disequilibrium (LD) structure of the MYBPC3 gene. Results: In a single locus analysis, SNP rs2290149 was associated with DHF (allele-specific p = 0.004; permuted p = 0.031). The SNP with a minor allele frequency of 9.4{\%}, had an odds ratio 2.14 (95{\%} CI 1.25-3.66; p = 0.004) for the additive model and 2.06 for the autosomal dominant model (GG+GA: AA, 95{\%} CI 1.17-3.63; p = 0.013), corresponding to a population attributable risk fraction of 12.02{\%}. The haplotypes in a LD block of rs2290149 (C-C-G-C) was also significantly associated with DHF (odds ratio 2.10 (1.53-2.89); permuted p = 0.029). Conclusions: We identified a SNP (rs2290149) among the tagging SNP set that was significantly associated with early DHF in a Chinese population.",
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AU - Lee, Jen Kuang

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AU - Chiang, Fu Tien

AU - Huang, Shu Wei

AU - Lin, Jiunn Lee

AU - Tseng, Chuen Den

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AB - Objective: Myosin binding protein C (MYBPC3) plays a role in ventricular relaxation. The aim of the study was to investigate the association between cardiac myosin binding protein C (MYBPC3) gene polymorphisms and diastolic heart failure (DHF) in a human case-control study. Methods: A total of 352 participants of 1752 consecutive patients from the National Taiwan University Hospital and its affiliated hospital were enrolled. 176 patients diagnosed with DHF confirmed by echocardiography were recruited. Controls were matched 1-to-1 by age, sex, hypertension, diabetes, renal function and medication use. We genotyped 12 single nucleotide polymorphisms (SNPs) according to HapMap Han Chinese Beijing databank across a 40 kb genetic region containing the MYBPC3 gene and the neighboring DNA sequences to capture 100% of haplotype variance in all SNPs with minor allele frequencies ≥5%. We also analyzed associations of these tagging SNPs and haplotypes with DHF and linkage disequilibrium (LD) structure of the MYBPC3 gene. Results: In a single locus analysis, SNP rs2290149 was associated with DHF (allele-specific p = 0.004; permuted p = 0.031). The SNP with a minor allele frequency of 9.4%, had an odds ratio 2.14 (95% CI 1.25-3.66; p = 0.004) for the additive model and 2.06 for the autosomal dominant model (GG+GA: AA, 95% CI 1.17-3.63; p = 0.013), corresponding to a population attributable risk fraction of 12.02%. The haplotypes in a LD block of rs2290149 (C-C-G-C) was also significantly associated with DHF (odds ratio 2.10 (1.53-2.89); permuted p = 0.029). Conclusions: We identified a SNP (rs2290149) among the tagging SNP set that was significantly associated with early DHF in a Chinese population.

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