Cardiac Complications Associated with Short-Term Mortality in Schizophrenia Patients Hospitalized for Pneumonia: A Nationwide Case-Control Study

Ya Tang Liao, Shu Yu Yang, Hsing Cheng Liu, Wei J. Chen, Chiao Chicy Chen, Yen Ni Hung, Chian Jue Kuo

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background:Pneumonia is one of most prevalent infectious diseases worldwide and is associated with considerable mortality. In comparison to general population, schizophrenia patients hospitalized for pneumonia have poorer outcomes. We explored the risk factors of short-term mortality in this population because the information is lacking in the literature.Methods:In a nationwide schizophrenia cohort, derived from the National Health Insurance Research Database in Taiwan, that was hospitalized for pneumonia between 2000 and 2008 (n = 1,741), we identified 141 subjects who died during their hospitalizations or shortly after their discharges. Based on risk-set sampling in a 1:4 ratio, 468 matched controls were selected from the study cohort (i.e., schizophrenia cohort with pneumonia). Physical illnesses were categorized as pre-existing and incident illnesses that developed after pneumonia respectively. Exposures to medications were categorized by type, duration, and defined daily dose. We used stepwise conditional logistic regression to explore the risk factors for short-term mortality.Results:Pre-existing arrhythmia was associated with short-term mortality (adjusted risk ratio [RR] = 4.99, p

Original languageEnglish
Article numbere70142
JournalPLoS One
Volume8
Issue number7
DOIs
Publication statusPublished - Jul 29 2013

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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