Cardiac autonomic dysregulation in patients with acute hepatitis

Kuan Yang Chen, Chien Lin Chen, Cheryl C H Yang, Terry B J Kuo

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

BACKGROUND: Autonomic dysfunction is common in patients with chronic liver disease, but it is still unclear whether acute hepatitis coincides with alterations in autonomic functions. METHODS: We evaluated the heart rate variability (HRV) of 10 patients with acute hepatitis (6 males, 4 females; mean age, 44.0 y; range, 20-69 y). Frequency-domain analysis of short-term and stationary R-R intervals was performed on the first day of admission to detect low-frequency power (LF; 0.04-0.15 Hz), high-frequency power (HF, 0.15-0.40 Hz), the ratio of LF to HF (LF/HF), and LF in normalized units (LF%). The same measurement was repeated on the 7th day of admission. RESULTS: We found that there was a significant increase of HF as well as variance of the R-R interval on the 7th day after admission (P < 0.05). There was a significant negative correlation between HF and the change of total bilirubin (P < 0.05). CONCLUSIONS: The study demonstrates a change in cardiac vagal tone associated with acute hepatitis by analysis of HRV, and such alteration is less pronounced later during the clinical course of acute hepatitis.

Original languageEnglish
Pages (from-to)164-167
Number of pages4
JournalAmerican Journal of the Medical Sciences
Volume332
Issue number4
DOIs
Publication statusPublished - Oct 2006
Externally publishedYes

Fingerprint

Hepatitis
Heart Rate
Bilirubin
Liver Diseases
Chronic Disease

Keywords

  • Acute hepatitis
  • Heart rate variability
  • Power spectral analysis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Cardiac autonomic dysregulation in patients with acute hepatitis. / Chen, Kuan Yang; Chen, Chien Lin; Yang, Cheryl C H; Kuo, Terry B J.

In: American Journal of the Medical Sciences, Vol. 332, No. 4, 10.2006, p. 164-167.

Research output: Contribution to journalArticle

Chen, Kuan Yang ; Chen, Chien Lin ; Yang, Cheryl C H ; Kuo, Terry B J. / Cardiac autonomic dysregulation in patients with acute hepatitis. In: American Journal of the Medical Sciences. 2006 ; Vol. 332, No. 4. pp. 164-167.
@article{5ab6692ba69649c1bb7befa189f7b9ff,
title = "Cardiac autonomic dysregulation in patients with acute hepatitis",
abstract = "BACKGROUND: Autonomic dysfunction is common in patients with chronic liver disease, but it is still unclear whether acute hepatitis coincides with alterations in autonomic functions. METHODS: We evaluated the heart rate variability (HRV) of 10 patients with acute hepatitis (6 males, 4 females; mean age, 44.0 y; range, 20-69 y). Frequency-domain analysis of short-term and stationary R-R intervals was performed on the first day of admission to detect low-frequency power (LF; 0.04-0.15 Hz), high-frequency power (HF, 0.15-0.40 Hz), the ratio of LF to HF (LF/HF), and LF in normalized units (LF{\%}). The same measurement was repeated on the 7th day of admission. RESULTS: We found that there was a significant increase of HF as well as variance of the R-R interval on the 7th day after admission (P < 0.05). There was a significant negative correlation between HF and the change of total bilirubin (P < 0.05). CONCLUSIONS: The study demonstrates a change in cardiac vagal tone associated with acute hepatitis by analysis of HRV, and such alteration is less pronounced later during the clinical course of acute hepatitis.",
keywords = "Acute hepatitis, Heart rate variability, Power spectral analysis",
author = "Chen, {Kuan Yang} and Chen, {Chien Lin} and Yang, {Cheryl C H} and Kuo, {Terry B J}",
year = "2006",
month = "10",
doi = "10.1097/00000441-200610000-00002",
language = "English",
volume = "332",
pages = "164--167",
journal = "American Journal of the Medical Sciences",
issn = "0002-9629",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Cardiac autonomic dysregulation in patients with acute hepatitis

AU - Chen, Kuan Yang

AU - Chen, Chien Lin

AU - Yang, Cheryl C H

AU - Kuo, Terry B J

PY - 2006/10

Y1 - 2006/10

N2 - BACKGROUND: Autonomic dysfunction is common in patients with chronic liver disease, but it is still unclear whether acute hepatitis coincides with alterations in autonomic functions. METHODS: We evaluated the heart rate variability (HRV) of 10 patients with acute hepatitis (6 males, 4 females; mean age, 44.0 y; range, 20-69 y). Frequency-domain analysis of short-term and stationary R-R intervals was performed on the first day of admission to detect low-frequency power (LF; 0.04-0.15 Hz), high-frequency power (HF, 0.15-0.40 Hz), the ratio of LF to HF (LF/HF), and LF in normalized units (LF%). The same measurement was repeated on the 7th day of admission. RESULTS: We found that there was a significant increase of HF as well as variance of the R-R interval on the 7th day after admission (P < 0.05). There was a significant negative correlation between HF and the change of total bilirubin (P < 0.05). CONCLUSIONS: The study demonstrates a change in cardiac vagal tone associated with acute hepatitis by analysis of HRV, and such alteration is less pronounced later during the clinical course of acute hepatitis.

AB - BACKGROUND: Autonomic dysfunction is common in patients with chronic liver disease, but it is still unclear whether acute hepatitis coincides with alterations in autonomic functions. METHODS: We evaluated the heart rate variability (HRV) of 10 patients with acute hepatitis (6 males, 4 females; mean age, 44.0 y; range, 20-69 y). Frequency-domain analysis of short-term and stationary R-R intervals was performed on the first day of admission to detect low-frequency power (LF; 0.04-0.15 Hz), high-frequency power (HF, 0.15-0.40 Hz), the ratio of LF to HF (LF/HF), and LF in normalized units (LF%). The same measurement was repeated on the 7th day of admission. RESULTS: We found that there was a significant increase of HF as well as variance of the R-R interval on the 7th day after admission (P < 0.05). There was a significant negative correlation between HF and the change of total bilirubin (P < 0.05). CONCLUSIONS: The study demonstrates a change in cardiac vagal tone associated with acute hepatitis by analysis of HRV, and such alteration is less pronounced later during the clinical course of acute hepatitis.

KW - Acute hepatitis

KW - Heart rate variability

KW - Power spectral analysis

UR - http://www.scopus.com/inward/record.url?scp=33749823143&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33749823143&partnerID=8YFLogxK

U2 - 10.1097/00000441-200610000-00002

DO - 10.1097/00000441-200610000-00002

M3 - Article

VL - 332

SP - 164

EP - 167

JO - American Journal of the Medical Sciences

JF - American Journal of the Medical Sciences

SN - 0002-9629

IS - 4

ER -