Carboxyfullerene decorated titanium dioxide nanomaterials for reactive oxygen species scavenging activities

Kai Cheng Yang, Jia Huei Zheng, Yen Ling Chen, Kuen Chan Lee, Er Chieh Cho

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Titanium dioxide nanomaterials offer superior protection for human skin against ultraviolet light. However, some reports have indicated that they might be associated with adverse effects such as cytotoxicity or reactive oxygen species (ROS) under UV-irradiation due to their nanoscale size. The surfaces of fullerenes are covered with π electrons, constituting aromatic structures, which can effectively scavenge large amounts of radicals. Unfortunately, their poor solubility in water, severe aggregation, and toxicity in biological applications when dispersed in solvent have imposed limitations on the use of fullerenes. Herein, we used carboxyfullerene as a radical scavenger to improve poor solubility. The modified materials were prepared through the esterification of C70-COOH with TNR (TNR/C70-COOH) and P25 (P25/C70-COOH). The structures and the properties were analyzed by using X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS) and high-resolution transmission electron microscopy (HRTEM). In order to investigate the scavenging radical abilities of TiO2 composites, pyridoxine (Vit. B6), nitroblue tetrazolium (NBT) and terephthalic acid (TA) were chosen to react with singlet oxygen, superoxide ions and hydroxyl radicals, respectively. The results show that both types of TiO2 composites could reduce the ROS in the environment and exhibit great potential in anti-oxidative and anti-inflammation applications.

Original languageEnglish
Pages (from-to)53025-53033
Number of pages9
JournalRSC Advances
Volume6
Issue number58
DOIs
Publication statusPublished - 2016

Fingerprint

Fullerenes
Scavenging
Nanostructured materials
Titanium dioxide
Reactive Oxygen Species
Solubility
Nitroblue Tetrazolium
Pyridoxine
Singlet Oxygen
Oxygen
Composite materials
Esterification
Cytotoxicity
High resolution transmission electron microscopy
Superoxides
Hydroxyl Radical
Toxicity
Energy dispersive spectroscopy
Skin
Agglomeration

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Chemistry(all)

Cite this

Carboxyfullerene decorated titanium dioxide nanomaterials for reactive oxygen species scavenging activities. / Yang, Kai Cheng; Zheng, Jia Huei; Chen, Yen Ling; Lee, Kuen Chan; Cho, Er Chieh.

In: RSC Advances, Vol. 6, No. 58, 2016, p. 53025-53033.

Research output: Contribution to journalArticle

Yang, Kai Cheng ; Zheng, Jia Huei ; Chen, Yen Ling ; Lee, Kuen Chan ; Cho, Er Chieh. / Carboxyfullerene decorated titanium dioxide nanomaterials for reactive oxygen species scavenging activities. In: RSC Advances. 2016 ; Vol. 6, No. 58. pp. 53025-53033.
@article{af0cada43d174788aa9b5722f3c598a6,
title = "Carboxyfullerene decorated titanium dioxide nanomaterials for reactive oxygen species scavenging activities",
abstract = "Titanium dioxide nanomaterials offer superior protection for human skin against ultraviolet light. However, some reports have indicated that they might be associated with adverse effects such as cytotoxicity or reactive oxygen species (ROS) under UV-irradiation due to their nanoscale size. The surfaces of fullerenes are covered with π electrons, constituting aromatic structures, which can effectively scavenge large amounts of radicals. Unfortunately, their poor solubility in water, severe aggregation, and toxicity in biological applications when dispersed in solvent have imposed limitations on the use of fullerenes. Herein, we used carboxyfullerene as a radical scavenger to improve poor solubility. The modified materials were prepared through the esterification of C70-COOH with TNR (TNR/C70-COOH) and P25 (P25/C70-COOH). The structures and the properties were analyzed by using X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS) and high-resolution transmission electron microscopy (HRTEM). In order to investigate the scavenging radical abilities of TiO2 composites, pyridoxine (Vit. B6), nitroblue tetrazolium (NBT) and terephthalic acid (TA) were chosen to react with singlet oxygen, superoxide ions and hydroxyl radicals, respectively. The results show that both types of TiO2 composites could reduce the ROS in the environment and exhibit great potential in anti-oxidative and anti-inflammation applications.",
author = "Yang, {Kai Cheng} and Zheng, {Jia Huei} and Chen, {Yen Ling} and Lee, {Kuen Chan} and Cho, {Er Chieh}",
year = "2016",
doi = "10.1039/c6ra09414g",
language = "English",
volume = "6",
pages = "53025--53033",
journal = "RSC Advances",
issn = "2046-2069",
publisher = "The Royal Society of Chemistry",
number = "58",

}

TY - JOUR

T1 - Carboxyfullerene decorated titanium dioxide nanomaterials for reactive oxygen species scavenging activities

AU - Yang, Kai Cheng

AU - Zheng, Jia Huei

AU - Chen, Yen Ling

AU - Lee, Kuen Chan

AU - Cho, Er Chieh

PY - 2016

Y1 - 2016

N2 - Titanium dioxide nanomaterials offer superior protection for human skin against ultraviolet light. However, some reports have indicated that they might be associated with adverse effects such as cytotoxicity or reactive oxygen species (ROS) under UV-irradiation due to their nanoscale size. The surfaces of fullerenes are covered with π electrons, constituting aromatic structures, which can effectively scavenge large amounts of radicals. Unfortunately, their poor solubility in water, severe aggregation, and toxicity in biological applications when dispersed in solvent have imposed limitations on the use of fullerenes. Herein, we used carboxyfullerene as a radical scavenger to improve poor solubility. The modified materials were prepared through the esterification of C70-COOH with TNR (TNR/C70-COOH) and P25 (P25/C70-COOH). The structures and the properties were analyzed by using X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS) and high-resolution transmission electron microscopy (HRTEM). In order to investigate the scavenging radical abilities of TiO2 composites, pyridoxine (Vit. B6), nitroblue tetrazolium (NBT) and terephthalic acid (TA) were chosen to react with singlet oxygen, superoxide ions and hydroxyl radicals, respectively. The results show that both types of TiO2 composites could reduce the ROS in the environment and exhibit great potential in anti-oxidative and anti-inflammation applications.

AB - Titanium dioxide nanomaterials offer superior protection for human skin against ultraviolet light. However, some reports have indicated that they might be associated with adverse effects such as cytotoxicity or reactive oxygen species (ROS) under UV-irradiation due to their nanoscale size. The surfaces of fullerenes are covered with π electrons, constituting aromatic structures, which can effectively scavenge large amounts of radicals. Unfortunately, their poor solubility in water, severe aggregation, and toxicity in biological applications when dispersed in solvent have imposed limitations on the use of fullerenes. Herein, we used carboxyfullerene as a radical scavenger to improve poor solubility. The modified materials were prepared through the esterification of C70-COOH with TNR (TNR/C70-COOH) and P25 (P25/C70-COOH). The structures and the properties were analyzed by using X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS) and high-resolution transmission electron microscopy (HRTEM). In order to investigate the scavenging radical abilities of TiO2 composites, pyridoxine (Vit. B6), nitroblue tetrazolium (NBT) and terephthalic acid (TA) were chosen to react with singlet oxygen, superoxide ions and hydroxyl radicals, respectively. The results show that both types of TiO2 composites could reduce the ROS in the environment and exhibit great potential in anti-oxidative and anti-inflammation applications.

UR - http://www.scopus.com/inward/record.url?scp=84973360152&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84973360152&partnerID=8YFLogxK

U2 - 10.1039/c6ra09414g

DO - 10.1039/c6ra09414g

M3 - Article

AN - SCOPUS:84973360152

VL - 6

SP - 53025

EP - 53033

JO - RSC Advances

JF - RSC Advances

SN - 2046-2069

IS - 58

ER -