Capsaicin supplementation reduces physical fatigue and improves exercise performance in mice

Yi Ju Hsu, Wen Ching Huang, Chien Chao Chiu, Yan Lin Liu, Wan Chun Chiu, Chun Hui Chiu, Yen Shuo Chiu, Chi Chang Huang

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Chili pepper is used as a food, seasoning and has been revered for its medicinal and health claims. It is very popular and is the most common spice worldwide. Capsaicin (CAP) is a major pungent and bioactive phytochemical in chili peppers. CAP has been shown to improve mitochondrial biogenesis and adenosine triphosphate (ATP) production. However, there is limited evidence around the effects of CAP on physical fatigue and exercise performance. The purpose of this study was to evaluate the potential beneficial effects of CAP on anti-fatigue and ergogenic functions following physiological challenge. Female Institute of Cancer Research (ICR) mice from four groups (n = 8 per group) were orally administered CAP for 4 weeks at 0, 205, 410, and 1025 mg/kg/day, which were respectively designated the vehicle, CAP-1X, CAP-2X, and CAP-5X groups. The anti-fatigue activity and exercise performance was evaluated using forelimb grip strength, exhaustive swimming time, and levels of serum lactate, ammonia, glucose, BUN (blood urea nitrogen) and creatine kinase (CK) after a 15-min swimming exercise. The grip strength and exhaustive swimming time of the CAP-5X group were significantly higher than other groups. CAP supplementation dose-dependently reduced serum lactate, ammonia, BUN and CK levels, and increased glucose concentration after the 15-min swimming test. In addition, CAP also increased hepatic glycogen content, an important energy source for exercise. The possible mechanism was relevant to energy homeostasis and the physiological modulations by CAP supplementation. Therefore, our results suggest that CAP supplementation may have a wide spectrum of bioactivities for promoting health, performance improvement and fatigue amelioration.

Original languageEnglish
Article number648
JournalNutrients
Volume8
Issue number10
DOIs
Publication statusPublished - Oct 1 2016

Fingerprint

capsaicin
Capsaicin
Fatigue
exercise
mice
Capsicum
hot peppers
Blood Urea Nitrogen
Hand Strength
creatine kinase
Creatine Kinase
urea nitrogen
blood serum
Ammonia
lactates
Lactic Acid
ammonia
Glucose
Spices
health promotion

Keywords

  • Anti-fatigue
  • Capsaicin
  • Exercise performance
  • Forelimb grip strength
  • Glycogen

ASJC Scopus subject areas

  • Food Science

Cite this

Hsu, Y. J., Huang, W. C., Chiu, C. C., Liu, Y. L., Chiu, W. C., Chiu, C. H., ... Huang, C. C. (2016). Capsaicin supplementation reduces physical fatigue and improves exercise performance in mice. Nutrients, 8(10), [648]. https://doi.org/10.3390/nu8100648

Capsaicin supplementation reduces physical fatigue and improves exercise performance in mice. / Hsu, Yi Ju; Huang, Wen Ching; Chiu, Chien Chao; Liu, Yan Lin; Chiu, Wan Chun; Chiu, Chun Hui; Chiu, Yen Shuo; Huang, Chi Chang.

In: Nutrients, Vol. 8, No. 10, 648, 01.10.2016.

Research output: Contribution to journalArticle

Hsu, Yi Ju ; Huang, Wen Ching ; Chiu, Chien Chao ; Liu, Yan Lin ; Chiu, Wan Chun ; Chiu, Chun Hui ; Chiu, Yen Shuo ; Huang, Chi Chang. / Capsaicin supplementation reduces physical fatigue and improves exercise performance in mice. In: Nutrients. 2016 ; Vol. 8, No. 10.
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