Capsaicin and nonivamide as novel skin permeation enhancers for indomethacin

Jia You Fang, Chia Lang Fang, Chi Tzong Hong, Hsiang Yin Chen, Tzu Ying Lin, Hsiu Mei Wei

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The study was conducted in vitro to investigate the changes of indomethacin transdermal permeation pretreated by capsaicin and nonivamide, two compounds chemically similar to Azone. The combined effect of low frequency ultrasound (20 kHz) and enhancers on the indomethacin permeation was also evaluated. The experimental data demonstrated that capsaicin and nonivamide significantly enhanced the flux of indomethacin across nude mouse skin. Enhancement effects of both analogues were very similar and depended predominantly on the concentration tested. Histological examination coupled with visual scores indicated the safety of capsaicin and nonivamide on skin structure. Simultaneous application of ultrasound and enhancers significantly increased skin permeation of indomethacin compared with either ultrasound or enhancers alone. Better effect was obtained by the combination with capsaicin than nonivamide. (C) 2001 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)195-203
Number of pages9
JournalEuropean Journal of Pharmaceutical Sciences
Volume12
Issue number3
DOIs
Publication statusPublished - 2000

Fingerprint

Capsaicin
Indomethacin
Skin
Nude Mice
Safety
nonivamide

Keywords

  • Capsaicin
  • Enhancer
  • Indomethacin
  • Nonivamide
  • Skin permeation
  • Ultrasound

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Capsaicin and nonivamide as novel skin permeation enhancers for indomethacin. / Fang, Jia You; Fang, Chia Lang; Hong, Chi Tzong; Chen, Hsiang Yin; Lin, Tzu Ying; Wei, Hsiu Mei.

In: European Journal of Pharmaceutical Sciences, Vol. 12, No. 3, 2000, p. 195-203.

Research output: Contribution to journalArticle

Fang, Jia You ; Fang, Chia Lang ; Hong, Chi Tzong ; Chen, Hsiang Yin ; Lin, Tzu Ying ; Wei, Hsiu Mei. / Capsaicin and nonivamide as novel skin permeation enhancers for indomethacin. In: European Journal of Pharmaceutical Sciences. 2000 ; Vol. 12, No. 3. pp. 195-203.
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