Abstract
Arsenic-induced skin cancer may be considered a long-term biomarker of cumulative arsenic exposure. Therefore, we conducted a genome-wide screening to discover novel genes associated with chronic arsenic-induced skin cancers in Taiwan. We included 83 patients with skin cancer and 83 age-, gender - and arsenic exposure level-matched subjects were selected as controls. Then, we conducted a case-control study consisting of 144 skin cancer patients and 631 cancer-free controls for replicating the candidate single nucleotide polymorphisms (SNPs) identified from the genome-wide screening. In a genome-wide screening, we selected four top genes including SYN3(synapsin III), LOXL1(Lysyl Oxidase- Like1), AUH (Au-Specific RNA-binding Protein) and SEC24D (an essential coat protein II) for genotyping. Two SNPs (SYN3 rs137537 G/T and SEC24D rs13127508 G/A) were significantly associated with the risk of skin cancer. In this pilot study, we identify two novel genes including SYN3 and SEC24D which were significantly associated with arsenic-associated skin cancers in Taiwan.
| Original language | English |
|---|---|
| Title of host publication | One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment |
| Publisher | CRC Press/Balkema |
| Pages | 509-510 |
| Number of pages | 2 |
| ISBN (Print) | 9781138001411 |
| Publication status | Published - 2014 |
| Event | 5th International Congress on Arsenic in the Environment, As 2014 - Buenos Aires, Argentina Duration: May 11 2014 → May 16 2014 |
Other
| Other | 5th International Congress on Arsenic in the Environment, As 2014 |
|---|---|
| Country | Argentina |
| City | Buenos Aires |
| Period | 5/11/14 → 5/16/14 |
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ASJC Scopus subject areas
- Chemical Health and Safety
Cite this
Candidate single nucleotide polymorphisms associated with arsenic-induced Bowen's disease in Taiwan - A pilot study. / Wang, Y. H.; Hsu, L. I.; Chen, C. J.
One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment. CRC Press/Balkema, 2014. p. 509-510.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Candidate single nucleotide polymorphisms associated with arsenic-induced Bowen's disease in Taiwan - A pilot study
AU - Wang, Y. H.
AU - Hsu, L. I.
AU - Chen, C. J.
PY - 2014
Y1 - 2014
N2 - Arsenic-induced skin cancer may be considered a long-term biomarker of cumulative arsenic exposure. Therefore, we conducted a genome-wide screening to discover novel genes associated with chronic arsenic-induced skin cancers in Taiwan. We included 83 patients with skin cancer and 83 age-, gender - and arsenic exposure level-matched subjects were selected as controls. Then, we conducted a case-control study consisting of 144 skin cancer patients and 631 cancer-free controls for replicating the candidate single nucleotide polymorphisms (SNPs) identified from the genome-wide screening. In a genome-wide screening, we selected four top genes including SYN3(synapsin III), LOXL1(Lysyl Oxidase- Like1), AUH (Au-Specific RNA-binding Protein) and SEC24D (an essential coat protein II) for genotyping. Two SNPs (SYN3 rs137537 G/T and SEC24D rs13127508 G/A) were significantly associated with the risk of skin cancer. In this pilot study, we identify two novel genes including SYN3 and SEC24D which were significantly associated with arsenic-associated skin cancers in Taiwan.
AB - Arsenic-induced skin cancer may be considered a long-term biomarker of cumulative arsenic exposure. Therefore, we conducted a genome-wide screening to discover novel genes associated with chronic arsenic-induced skin cancers in Taiwan. We included 83 patients with skin cancer and 83 age-, gender - and arsenic exposure level-matched subjects were selected as controls. Then, we conducted a case-control study consisting of 144 skin cancer patients and 631 cancer-free controls for replicating the candidate single nucleotide polymorphisms (SNPs) identified from the genome-wide screening. In a genome-wide screening, we selected four top genes including SYN3(synapsin III), LOXL1(Lysyl Oxidase- Like1), AUH (Au-Specific RNA-binding Protein) and SEC24D (an essential coat protein II) for genotyping. Two SNPs (SYN3 rs137537 G/T and SEC24D rs13127508 G/A) were significantly associated with the risk of skin cancer. In this pilot study, we identify two novel genes including SYN3 and SEC24D which were significantly associated with arsenic-associated skin cancers in Taiwan.
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UR - http://www.scopus.com/inward/citedby.url?scp=84907372023&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:84907372023
SN - 9781138001411
SP - 509
EP - 510
BT - One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment
PB - CRC Press/Balkema
ER -