Candidate single nucleotide polymorphisms associated with arsenic-induced Bowen's disease in Taiwan - A pilot study

Y. H. Wang, L. I. Hsu, C. J. Chen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Arsenic-induced skin cancer may be considered a long-term biomarker of cumulative arsenic exposure. Therefore, we conducted a genome-wide screening to discover novel genes associated with chronic arsenic-induced skin cancers in Taiwan. We included 83 patients with skin cancer and 83 age-, gender - and arsenic exposure level-matched subjects were selected as controls. Then, we conducted a case-control study consisting of 144 skin cancer patients and 631 cancer-free controls for replicating the candidate single nucleotide polymorphisms (SNPs) identified from the genome-wide screening. In a genome-wide screening, we selected four top genes including SYN3(synapsin III), LOXL1(Lysyl Oxidase- Like1), AUH (Au-Specific RNA-binding Protein) and SEC24D (an essential coat protein II) for genotyping. Two SNPs (SYN3 rs137537 G/T and SEC24D rs13127508 G/A) were significantly associated with the risk of skin cancer. In this pilot study, we identify two novel genes including SYN3 and SEC24D which were significantly associated with arsenic-associated skin cancers in Taiwan.

Original languageEnglish
Title of host publicationOne Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment
PublisherCRC Press/Balkema
Pages509-510
Number of pages2
ISBN (Print)9781138001411
Publication statusPublished - 2014
Event5th International Congress on Arsenic in the Environment, As 2014 - Buenos Aires, Argentina
Duration: May 11 2014May 16 2014

Other

Other5th International Congress on Arsenic in the Environment, As 2014
CountryArgentina
CityBuenos Aires
Period5/11/145/16/14

ASJC Scopus subject areas

  • Chemical Health and Safety

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    Wang, Y. H., Hsu, L. I., & Chen, C. J. (2014). Candidate single nucleotide polymorphisms associated with arsenic-induced Bowen's disease in Taiwan - A pilot study. In One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment (pp. 509-510). CRC Press/Balkema.