Cancers in the TREAT Asia HIV Observational Database (TAHOD)

A retrospective analysis of risk factors

Kathy Petoumenos, Eugenie Hui, Nagalingeswaran Kumarasamy, Stephen J. Kerr, Jun Yong Choi, Yi Ming A. Chen, Tuti Merati, Fujie Zhang, Poh Lian Lim, Somnuek Sungkanuparph, Sanjay Pujari, Sasheela Ponnampalavanar, Rosanna Ditangco, Christopher Kc Lee, Andrew Grulich, Matthew G. Law

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background. This retrospective survey describes types of cancers diagnosed in HIV-infected subjects in Asia, and assesses risk factors for cancer in HIV-infected subjects using contemporaneous HIV-infected controls without cancer. Methods. TREAT Asia HIV Observational Database (TAHOD) sites retrospectively reviewed clinic medical records to determine cancer diagnoses since 2000. For each diagnosis, the following data were recorded: date, type, stage, method of diagnosis, demographic data, medical history, and HIV-related information. For risk factor analyses, two HIV-infected control subjects without cancer diagnoses were also selected. Cancers were grouped as AIDS-defining cancers (ADCs), and non-ADCs. Non-ADCs were further categorized as being infection related (NADC-IR) and unrelated (NADC-IUR). Results. A total of 617 patients were included in this study: 215 cancer cases and 402 controls from 13 sites. The majority of cancer cases were male (71%). The mean age (SD) for cases was 39 (10.6), 46 (11.5) and 44 (13.7) for ADCs, NADC-IURs and NADCs-IR, respectively. The majority (66%) of cancers were ADCs (16% Kaposi sarcoma, 40% non-Hodgkin's lymphoma, and 9% cervical cancer). The most common NADCs were lung (6%), breast (5%) and hepatocellular carcinoma and Hodgkin's lymphoma (2% each). There were also three (1.4%) cases of leiomyosarcoma reported in this study. In multivariate analyses, individuals with CD4 counts above 200 cells/mm3 were approximately 80% less likely to be diagnosed with an ADC (p < 0.001). Older age (OR: 1.39, p = 0.001) and currently not receiving antiretroviral treatment (OR: 0.29, p = 0.006) were independent predictors of NADCs overall, and similarly for NADCs-IUR. Lower CD4 cell count and higher CDC stage (p = 0.041) were the only independent predictors of NADCs-IR. Conclusions. The spectrum of cancer diagnoses in the Asia region currently does not appear dissimilar to that observed in non-Asian HIV populations. One interesting finding was the cases of leiomyosarcoma, a smooth-muscle tumour, usually seen in children and young adults with AIDS, yet overall quite rare. Further detailed studies are required to better describe the range of cancers in this region, and to help guide the development of screening programmes.

Original languageEnglish
Article number51
JournalJournal of the International AIDS Society
Volume13
Issue number1
DOIs
Publication statusPublished - Dec 13 2010
Externally publishedYes

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HIV
Databases
Neoplasms
Acquired Immunodeficiency Syndrome
Leiomyosarcoma
CD4 Lymphocyte Count
Smooth Muscle Tumor
Program Development
Kaposi's Sarcoma
Centers for Disease Control and Prevention (U.S.)
N-acetoacetyl-N-deacetylcolchicine
Hodgkin Disease
Uterine Cervical Neoplasms
Non-Hodgkin's Lymphoma
Statistical Factor Analysis
Medical Records
Young Adult
Hepatocellular Carcinoma
Multivariate Analysis
Demography

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

Cancers in the TREAT Asia HIV Observational Database (TAHOD) : A retrospective analysis of risk factors. / Petoumenos, Kathy; Hui, Eugenie; Kumarasamy, Nagalingeswaran; Kerr, Stephen J.; Choi, Jun Yong; Chen, Yi Ming A.; Merati, Tuti; Zhang, Fujie; Lim, Poh Lian; Sungkanuparph, Somnuek; Pujari, Sanjay; Ponnampalavanar, Sasheela; Ditangco, Rosanna; Lee, Christopher Kc; Grulich, Andrew; Law, Matthew G.

In: Journal of the International AIDS Society, Vol. 13, No. 1, 51, 13.12.2010.

Research output: Contribution to journalArticle

Petoumenos, K, Hui, E, Kumarasamy, N, Kerr, SJ, Choi, JY, Chen, YMA, Merati, T, Zhang, F, Lim, PL, Sungkanuparph, S, Pujari, S, Ponnampalavanar, S, Ditangco, R, Lee, CK, Grulich, A & Law, MG 2010, 'Cancers in the TREAT Asia HIV Observational Database (TAHOD): A retrospective analysis of risk factors', Journal of the International AIDS Society, vol. 13, no. 1, 51. https://doi.org/10.1186/1758-2652-13-51
Petoumenos, Kathy ; Hui, Eugenie ; Kumarasamy, Nagalingeswaran ; Kerr, Stephen J. ; Choi, Jun Yong ; Chen, Yi Ming A. ; Merati, Tuti ; Zhang, Fujie ; Lim, Poh Lian ; Sungkanuparph, Somnuek ; Pujari, Sanjay ; Ponnampalavanar, Sasheela ; Ditangco, Rosanna ; Lee, Christopher Kc ; Grulich, Andrew ; Law, Matthew G. / Cancers in the TREAT Asia HIV Observational Database (TAHOD) : A retrospective analysis of risk factors. In: Journal of the International AIDS Society. 2010 ; Vol. 13, No. 1.
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title = "Cancers in the TREAT Asia HIV Observational Database (TAHOD): A retrospective analysis of risk factors",
abstract = "Background. This retrospective survey describes types of cancers diagnosed in HIV-infected subjects in Asia, and assesses risk factors for cancer in HIV-infected subjects using contemporaneous HIV-infected controls without cancer. Methods. TREAT Asia HIV Observational Database (TAHOD) sites retrospectively reviewed clinic medical records to determine cancer diagnoses since 2000. For each diagnosis, the following data were recorded: date, type, stage, method of diagnosis, demographic data, medical history, and HIV-related information. For risk factor analyses, two HIV-infected control subjects without cancer diagnoses were also selected. Cancers were grouped as AIDS-defining cancers (ADCs), and non-ADCs. Non-ADCs were further categorized as being infection related (NADC-IR) and unrelated (NADC-IUR). Results. A total of 617 patients were included in this study: 215 cancer cases and 402 controls from 13 sites. The majority of cancer cases were male (71{\%}). The mean age (SD) for cases was 39 (10.6), 46 (11.5) and 44 (13.7) for ADCs, NADC-IURs and NADCs-IR, respectively. The majority (66{\%}) of cancers were ADCs (16{\%} Kaposi sarcoma, 40{\%} non-Hodgkin's lymphoma, and 9{\%} cervical cancer). The most common NADCs were lung (6{\%}), breast (5{\%}) and hepatocellular carcinoma and Hodgkin's lymphoma (2{\%} each). There were also three (1.4{\%}) cases of leiomyosarcoma reported in this study. In multivariate analyses, individuals with CD4 counts above 200 cells/mm3 were approximately 80{\%} less likely to be diagnosed with an ADC (p < 0.001). Older age (OR: 1.39, p = 0.001) and currently not receiving antiretroviral treatment (OR: 0.29, p = 0.006) were independent predictors of NADCs overall, and similarly for NADCs-IUR. Lower CD4 cell count and higher CDC stage (p = 0.041) were the only independent predictors of NADCs-IR. Conclusions. The spectrum of cancer diagnoses in the Asia region currently does not appear dissimilar to that observed in non-Asian HIV populations. One interesting finding was the cases of leiomyosarcoma, a smooth-muscle tumour, usually seen in children and young adults with AIDS, yet overall quite rare. Further detailed studies are required to better describe the range of cancers in this region, and to help guide the development of screening programmes.",
author = "Kathy Petoumenos and Eugenie Hui and Nagalingeswaran Kumarasamy and Kerr, {Stephen J.} and Choi, {Jun Yong} and Chen, {Yi Ming A.} and Tuti Merati and Fujie Zhang and Lim, {Poh Lian} and Somnuek Sungkanuparph and Sanjay Pujari and Sasheela Ponnampalavanar and Rosanna Ditangco and Lee, {Christopher Kc} and Andrew Grulich and Law, {Matthew G.}",
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T1 - Cancers in the TREAT Asia HIV Observational Database (TAHOD)

T2 - A retrospective analysis of risk factors

AU - Petoumenos, Kathy

AU - Hui, Eugenie

AU - Kumarasamy, Nagalingeswaran

AU - Kerr, Stephen J.

AU - Choi, Jun Yong

AU - Chen, Yi Ming A.

AU - Merati, Tuti

AU - Zhang, Fujie

AU - Lim, Poh Lian

AU - Sungkanuparph, Somnuek

AU - Pujari, Sanjay

AU - Ponnampalavanar, Sasheela

AU - Ditangco, Rosanna

AU - Lee, Christopher Kc

AU - Grulich, Andrew

AU - Law, Matthew G.

PY - 2010/12/13

Y1 - 2010/12/13

N2 - Background. This retrospective survey describes types of cancers diagnosed in HIV-infected subjects in Asia, and assesses risk factors for cancer in HIV-infected subjects using contemporaneous HIV-infected controls without cancer. Methods. TREAT Asia HIV Observational Database (TAHOD) sites retrospectively reviewed clinic medical records to determine cancer diagnoses since 2000. For each diagnosis, the following data were recorded: date, type, stage, method of diagnosis, demographic data, medical history, and HIV-related information. For risk factor analyses, two HIV-infected control subjects without cancer diagnoses were also selected. Cancers were grouped as AIDS-defining cancers (ADCs), and non-ADCs. Non-ADCs were further categorized as being infection related (NADC-IR) and unrelated (NADC-IUR). Results. A total of 617 patients were included in this study: 215 cancer cases and 402 controls from 13 sites. The majority of cancer cases were male (71%). The mean age (SD) for cases was 39 (10.6), 46 (11.5) and 44 (13.7) for ADCs, NADC-IURs and NADCs-IR, respectively. The majority (66%) of cancers were ADCs (16% Kaposi sarcoma, 40% non-Hodgkin's lymphoma, and 9% cervical cancer). The most common NADCs were lung (6%), breast (5%) and hepatocellular carcinoma and Hodgkin's lymphoma (2% each). There were also three (1.4%) cases of leiomyosarcoma reported in this study. In multivariate analyses, individuals with CD4 counts above 200 cells/mm3 were approximately 80% less likely to be diagnosed with an ADC (p < 0.001). Older age (OR: 1.39, p = 0.001) and currently not receiving antiretroviral treatment (OR: 0.29, p = 0.006) were independent predictors of NADCs overall, and similarly for NADCs-IUR. Lower CD4 cell count and higher CDC stage (p = 0.041) were the only independent predictors of NADCs-IR. Conclusions. The spectrum of cancer diagnoses in the Asia region currently does not appear dissimilar to that observed in non-Asian HIV populations. One interesting finding was the cases of leiomyosarcoma, a smooth-muscle tumour, usually seen in children and young adults with AIDS, yet overall quite rare. Further detailed studies are required to better describe the range of cancers in this region, and to help guide the development of screening programmes.

AB - Background. This retrospective survey describes types of cancers diagnosed in HIV-infected subjects in Asia, and assesses risk factors for cancer in HIV-infected subjects using contemporaneous HIV-infected controls without cancer. Methods. TREAT Asia HIV Observational Database (TAHOD) sites retrospectively reviewed clinic medical records to determine cancer diagnoses since 2000. For each diagnosis, the following data were recorded: date, type, stage, method of diagnosis, demographic data, medical history, and HIV-related information. For risk factor analyses, two HIV-infected control subjects without cancer diagnoses were also selected. Cancers were grouped as AIDS-defining cancers (ADCs), and non-ADCs. Non-ADCs were further categorized as being infection related (NADC-IR) and unrelated (NADC-IUR). Results. A total of 617 patients were included in this study: 215 cancer cases and 402 controls from 13 sites. The majority of cancer cases were male (71%). The mean age (SD) for cases was 39 (10.6), 46 (11.5) and 44 (13.7) for ADCs, NADC-IURs and NADCs-IR, respectively. The majority (66%) of cancers were ADCs (16% Kaposi sarcoma, 40% non-Hodgkin's lymphoma, and 9% cervical cancer). The most common NADCs were lung (6%), breast (5%) and hepatocellular carcinoma and Hodgkin's lymphoma (2% each). There were also three (1.4%) cases of leiomyosarcoma reported in this study. In multivariate analyses, individuals with CD4 counts above 200 cells/mm3 were approximately 80% less likely to be diagnosed with an ADC (p < 0.001). Older age (OR: 1.39, p = 0.001) and currently not receiving antiretroviral treatment (OR: 0.29, p = 0.006) were independent predictors of NADCs overall, and similarly for NADCs-IUR. Lower CD4 cell count and higher CDC stage (p = 0.041) were the only independent predictors of NADCs-IR. Conclusions. The spectrum of cancer diagnoses in the Asia region currently does not appear dissimilar to that observed in non-Asian HIV populations. One interesting finding was the cases of leiomyosarcoma, a smooth-muscle tumour, usually seen in children and young adults with AIDS, yet overall quite rare. Further detailed studies are required to better describe the range of cancers in this region, and to help guide the development of screening programmes.

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