Cancer risks in a population with prolonged low dose-rate γ-radiation exposure in radiocontaminated buildings, 1983-2002

S. L. Hwang, H. R. Guo, W. A. Hsieh, J. S. Hwang, S. D. Lee, J. L. Tang, C. C. Chen, T. C. Chang, J. D. Wang, W. P. Chang

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Purpose: To assess cancer risks in a population that received prolonged low dose-rate γ-irradiation for about 10 years as a result of occupying buildings containing 60Co-contaminated steel in Taiwan. Materials and methods: The cancer risks were compared with those populations with the same temporal and geographic characteristics in Taiwan by standardized incidence ratios (SIR), adjusted for age and gender. The association of cancer risks with excess cumulative exposure was further evaluated for their relative risks by the Poisson multiple regression analysis. Result: A total of 7271 people were registered as the exposed population, with 101,560 person-years at risk. The average excess cumulative exposure was approximately 47.8 mSv (range <1 - 2,363 mSv). A total of 141 exposed subjects with various cancers were observed, while 95 developed leukemia or solid cancers after more than 2 or 10 years initial residence in contaminated buildings respectively. The SIR were significantly higher for all leukemia except chronic lymphocytic leukemia (n = 6, SIR = 3.6, 95% confidence interval [CI] 1.2 - 7.4) in men, and marginally significant for thyroid cancers (n = 6, SIR = 2.6, 95% CI 1.0 - 5.7) in women. On the other hand, all cancers combined, all solid cancers combined were shown to exhibit significant exposure-dependent increased risks in individuals with the initial exposure before the age of 30, but not beyond this age. Conclusions: The results suggest that prolonged low dose-rate radiation exposure appeared to increase risks of developing certain cancers in specific subgroups of this population in Taiwan.

Original languageEnglish
Pages (from-to)849-858
Number of pages10
JournalInternational Journal of Radiation Biology
Volume82
Issue number12
DOIs
Publication statusPublished - Dec 1 2006
Externally publishedYes

Fingerprint

radiation dosage
Dosimetry
cancer
Radiation
dosage
neoplasms
Population
Neoplasms
leukemias
Taiwan
cumulative exposure
incidence
Incidence
leukemia
confidence interval
Leukemia
confidence
Confidence Intervals
lymphocytic leukemia
intervals

Keywords

  • Co
  • Cancer risk
  • Human population
  • Low dose-rate
  • Radiation

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Nuclear Energy and Engineering
  • Radiation

Cite this

Cancer risks in a population with prolonged low dose-rate γ-radiation exposure in radiocontaminated buildings, 1983-2002. / Hwang, S. L.; Guo, H. R.; Hsieh, W. A.; Hwang, J. S.; Lee, S. D.; Tang, J. L.; Chen, C. C.; Chang, T. C.; Wang, J. D.; Chang, W. P.

In: International Journal of Radiation Biology, Vol. 82, No. 12, 01.12.2006, p. 849-858.

Research output: Contribution to journalArticle

Hwang, SL, Guo, HR, Hsieh, WA, Hwang, JS, Lee, SD, Tang, JL, Chen, CC, Chang, TC, Wang, JD & Chang, WP 2006, 'Cancer risks in a population with prolonged low dose-rate γ-radiation exposure in radiocontaminated buildings, 1983-2002', International Journal of Radiation Biology, vol. 82, no. 12, pp. 849-858. https://doi.org/10.1080/09553000601085980
Hwang, S. L. ; Guo, H. R. ; Hsieh, W. A. ; Hwang, J. S. ; Lee, S. D. ; Tang, J. L. ; Chen, C. C. ; Chang, T. C. ; Wang, J. D. ; Chang, W. P. / Cancer risks in a population with prolonged low dose-rate γ-radiation exposure in radiocontaminated buildings, 1983-2002. In: International Journal of Radiation Biology. 2006 ; Vol. 82, No. 12. pp. 849-858.
@article{5fb0fcfc84e649e08d63a962b7194514,
title = "Cancer risks in a population with prolonged low dose-rate γ-radiation exposure in radiocontaminated buildings, 1983-2002",
abstract = "Purpose: To assess cancer risks in a population that received prolonged low dose-rate γ-irradiation for about 10 years as a result of occupying buildings containing 60Co-contaminated steel in Taiwan. Materials and methods: The cancer risks were compared with those populations with the same temporal and geographic characteristics in Taiwan by standardized incidence ratios (SIR), adjusted for age and gender. The association of cancer risks with excess cumulative exposure was further evaluated for their relative risks by the Poisson multiple regression analysis. Result: A total of 7271 people were registered as the exposed population, with 101,560 person-years at risk. The average excess cumulative exposure was approximately 47.8 mSv (range <1 - 2,363 mSv). A total of 141 exposed subjects with various cancers were observed, while 95 developed leukemia or solid cancers after more than 2 or 10 years initial residence in contaminated buildings respectively. The SIR were significantly higher for all leukemia except chronic lymphocytic leukemia (n = 6, SIR = 3.6, 95{\%} confidence interval [CI] 1.2 - 7.4) in men, and marginally significant for thyroid cancers (n = 6, SIR = 2.6, 95{\%} CI 1.0 - 5.7) in women. On the other hand, all cancers combined, all solid cancers combined were shown to exhibit significant exposure-dependent increased risks in individuals with the initial exposure before the age of 30, but not beyond this age. Conclusions: The results suggest that prolonged low dose-rate radiation exposure appeared to increase risks of developing certain cancers in specific subgroups of this population in Taiwan.",
keywords = "Co, Cancer risk, Human population, Low dose-rate, Radiation",
author = "Hwang, {S. L.} and Guo, {H. R.} and Hsieh, {W. A.} and Hwang, {J. S.} and Lee, {S. D.} and Tang, {J. L.} and Chen, {C. C.} and Chang, {T. C.} and Wang, {J. D.} and Chang, {W. P.}",
year = "2006",
month = "12",
day = "1",
doi = "10.1080/09553000601085980",
language = "English",
volume = "82",
pages = "849--858",
journal = "International Journal of Radiation Biology",
issn = "0955-3002",
publisher = "Informa Healthcare",
number = "12",

}

TY - JOUR

T1 - Cancer risks in a population with prolonged low dose-rate γ-radiation exposure in radiocontaminated buildings, 1983-2002

AU - Hwang, S. L.

AU - Guo, H. R.

AU - Hsieh, W. A.

AU - Hwang, J. S.

AU - Lee, S. D.

AU - Tang, J. L.

AU - Chen, C. C.

AU - Chang, T. C.

AU - Wang, J. D.

AU - Chang, W. P.

PY - 2006/12/1

Y1 - 2006/12/1

N2 - Purpose: To assess cancer risks in a population that received prolonged low dose-rate γ-irradiation for about 10 years as a result of occupying buildings containing 60Co-contaminated steel in Taiwan. Materials and methods: The cancer risks were compared with those populations with the same temporal and geographic characteristics in Taiwan by standardized incidence ratios (SIR), adjusted for age and gender. The association of cancer risks with excess cumulative exposure was further evaluated for their relative risks by the Poisson multiple regression analysis. Result: A total of 7271 people were registered as the exposed population, with 101,560 person-years at risk. The average excess cumulative exposure was approximately 47.8 mSv (range <1 - 2,363 mSv). A total of 141 exposed subjects with various cancers were observed, while 95 developed leukemia or solid cancers after more than 2 or 10 years initial residence in contaminated buildings respectively. The SIR were significantly higher for all leukemia except chronic lymphocytic leukemia (n = 6, SIR = 3.6, 95% confidence interval [CI] 1.2 - 7.4) in men, and marginally significant for thyroid cancers (n = 6, SIR = 2.6, 95% CI 1.0 - 5.7) in women. On the other hand, all cancers combined, all solid cancers combined were shown to exhibit significant exposure-dependent increased risks in individuals with the initial exposure before the age of 30, but not beyond this age. Conclusions: The results suggest that prolonged low dose-rate radiation exposure appeared to increase risks of developing certain cancers in specific subgroups of this population in Taiwan.

AB - Purpose: To assess cancer risks in a population that received prolonged low dose-rate γ-irradiation for about 10 years as a result of occupying buildings containing 60Co-contaminated steel in Taiwan. Materials and methods: The cancer risks were compared with those populations with the same temporal and geographic characteristics in Taiwan by standardized incidence ratios (SIR), adjusted for age and gender. The association of cancer risks with excess cumulative exposure was further evaluated for their relative risks by the Poisson multiple regression analysis. Result: A total of 7271 people were registered as the exposed population, with 101,560 person-years at risk. The average excess cumulative exposure was approximately 47.8 mSv (range <1 - 2,363 mSv). A total of 141 exposed subjects with various cancers were observed, while 95 developed leukemia or solid cancers after more than 2 or 10 years initial residence in contaminated buildings respectively. The SIR were significantly higher for all leukemia except chronic lymphocytic leukemia (n = 6, SIR = 3.6, 95% confidence interval [CI] 1.2 - 7.4) in men, and marginally significant for thyroid cancers (n = 6, SIR = 2.6, 95% CI 1.0 - 5.7) in women. On the other hand, all cancers combined, all solid cancers combined were shown to exhibit significant exposure-dependent increased risks in individuals with the initial exposure before the age of 30, but not beyond this age. Conclusions: The results suggest that prolonged low dose-rate radiation exposure appeared to increase risks of developing certain cancers in specific subgroups of this population in Taiwan.

KW - Co

KW - Cancer risk

KW - Human population

KW - Low dose-rate

KW - Radiation

UR - http://www.scopus.com/inward/record.url?scp=33845789053&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33845789053&partnerID=8YFLogxK

U2 - 10.1080/09553000601085980

DO - 10.1080/09553000601085980

M3 - Article

C2 - 17178625

AN - SCOPUS:33845789053

VL - 82

SP - 849

EP - 858

JO - International Journal of Radiation Biology

JF - International Journal of Radiation Biology

SN - 0955-3002

IS - 12

ER -