Cancer risk among gingivitis and periodontitis patients: A nationwide cohort study

B. W. Wen, Chin Shaw Stella Tsai, Cheng Li Lin, Yen Jung Chang, C. F. Lee, Chung-Huei Hsu, Chia Hung Kao

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39 Citations (Scopus)

Abstract

Aim: Periodontal disease encompasses gingivitis and periodontitis, which exerts systemic effects. We conducted a population-based study to evaluate the association between periodontal disease and the risk of cancer. Methods: We used insurance claims data from 1997 to 2010, accessing a database of 1 million randomly selected insurants in Taiwan. All patients were older than 20 and newly diagnosed with periodontitis between 1 January 1997 and 31 December 2010. The comparison cohort comprised patients older than 20, who were newly diagnosed with gingivitis in the same period. Both cohorts were followed until a cancer diagnosis, lost to follow-up, death, termination of insurance, or the end of 2010. Results: The incidence rate of cancer was 1.14 times higher in the study cohort than in the comparison cohort [confidence interval (CI) = 1.11-1.17]. The adjusted hazard ratio (HR) was 1.05 (95% CI = 1.00-1.11). A multivariable analysis showed that the periodontitis patients exhibited an elevated risk of developing oral cancer (adjusted HR = 1.79, 95% CI = 1.42-2.25). Conclusion: The findings indicated that patients in the periodontitis cohort exhibited a higher risk of developing oral cancer than those in the gingivitis cohort.

Original languageEnglish
Article numberhct248
Pages (from-to)283-290
Number of pages8
JournalQJM
Volume107
Issue number4
DOIs
Publication statusPublished - 2014

ASJC Scopus subject areas

  • Medicine(all)

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    Wen, B. W., Tsai, C. S. S., Lin, C. L., Chang, Y. J., Lee, C. F., Hsu, C-H., & Kao, C. H. (2014). Cancer risk among gingivitis and periodontitis patients: A nationwide cohort study. QJM, 107(4), 283-290. [hct248]. https://doi.org/10.1093/qjmed/hct248