Cancer incidence among heart, kidney, and liver transplant recipients in Taiwan

Kwai Fong Lee, Yi Ting Tsai, Chih Yuan Lin, Chung Bao Hsieh, Sheng Tang Wu, Hung Yen Ke, Yi Chang Lin, Feng Yen Lin, Wei Hwa Lee, Chien Sung Tsai

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Population-based evidence of the relative risk of cancer among heart, kidney, and liver transplant recipients from Asia is lacking. The Taiwan National Health Insurance Research Database was used to conduct a population-based cohort study of transplant recipients (n = 5396), comprising 801 heart, 2847 kidney, and 1748 liver transplant recipients between 2001 and 2012. Standardized incidence ratios and Cox regression models were used. Compared with the general population, the risk of cancer increased 3.8-fold after heart transplantation, 4.1-fold after kidney transplantation and 4.6-fold after liver transplantation. Cancer occurrence showed considerable variation according to transplanted organs. The most common cancers in all transplant patients were cancers of the head and neck, liver, bladder, and kidney and non-Hodgkin lymphoma. Male recipients had an increased risk of cancers of the head and neck and liver, and female kidney recipients had a significant risk of bladder and kidney cancer. The adjusted hazard ratio for any cancer in all recipients was higher in liver transplant recipients compared with that in heart transplant recipients (hazard ratio = 1.5, P = .04). Cancer occurrence varied considerably and posttransplant cancer screening should be performed routinely according to transplanted organ and sex.

Original languageEnglish
Article numbere0155602
JournalPLoS One
Volume11
Issue number5
DOIs
Publication statusPublished - May 1 2016

Fingerprint

heart transplant
liver transplant
kidney transplant
Transplants
Taiwan
Liver
Kidney
incidence
neoplasms
Incidence
Neoplasms
Head and Neck Neoplasms
kidneys
Hazards
Population
Heart Neoplasms
Health insurance
Kidney Neoplasms
National Health Programs
Heart Transplantation

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Lee, K. F., Tsai, Y. T., Lin, C. Y., Hsieh, C. B., Wu, S. T., Ke, H. Y., ... Tsai, C. S. (2016). Cancer incidence among heart, kidney, and liver transplant recipients in Taiwan. PLoS One, 11(5), [e0155602]. https://doi.org/10.1371/journal.pone.0155602

Cancer incidence among heart, kidney, and liver transplant recipients in Taiwan. / Lee, Kwai Fong; Tsai, Yi Ting; Lin, Chih Yuan; Hsieh, Chung Bao; Wu, Sheng Tang; Ke, Hung Yen; Lin, Yi Chang; Lin, Feng Yen; Lee, Wei Hwa; Tsai, Chien Sung.

In: PLoS One, Vol. 11, No. 5, e0155602, 01.05.2016.

Research output: Contribution to journalArticle

Lee, KF, Tsai, YT, Lin, CY, Hsieh, CB, Wu, ST, Ke, HY, Lin, YC, Lin, FY, Lee, WH & Tsai, CS 2016, 'Cancer incidence among heart, kidney, and liver transplant recipients in Taiwan', PLoS One, vol. 11, no. 5, e0155602. https://doi.org/10.1371/journal.pone.0155602
Lee, Kwai Fong ; Tsai, Yi Ting ; Lin, Chih Yuan ; Hsieh, Chung Bao ; Wu, Sheng Tang ; Ke, Hung Yen ; Lin, Yi Chang ; Lin, Feng Yen ; Lee, Wei Hwa ; Tsai, Chien Sung. / Cancer incidence among heart, kidney, and liver transplant recipients in Taiwan. In: PLoS One. 2016 ; Vol. 11, No. 5.
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