Cancer cell-specific oligopeptide selected by microfluidic system from a phage display library for ovarian cancer diagnosis

Chih Hung Wang, Chen Hsun Weng, Yu Jui Che, Kuan Wang, Gwo Bin Lee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Ovarian cancer has been one of the leading causes of death for women. However, it is still very challenging for its early diagnosis. The tedious conventional methods for screening specific biomarkers need at least two weeks or more. It was reported that cancer-specific oligopeptides could be screened from a phage display library. In this study, a new integrated microfluidic chip was developed to perform the entire screening process for specific oligopeptide selection of ovarian cancer cells. The screened oligopeptide was demonstrated to have high affinity with ovarian cancer cells and relatively low capture rate with other types of cancer cells. It is therefore promising to use the screened oligopeptide for isolation of ovarian cancer cells in the near future.

Original languageEnglish
Title of host publication17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
PublisherChemical and Biological Microsystems Society
Pages1953-1955
Number of pages3
ISBN (Print)9781632666246
Publication statusPublished - Jan 1 2013
Externally publishedYes
Event17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 - Freiburg, Germany
Duration: Oct 27 2013Oct 31 2013

Publication series

Name17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
Volume3

Conference

Conference17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
CountryGermany
CityFreiburg
Period10/27/1310/31/13

Fingerprint

Fluidic devices
Bacteriophages
Biomarkers
Microfluidics
Display devices
Cells
Screening
Oligopeptides

Keywords

  • Biomarker
  • Microfluidic
  • Ovarian cancer
  • Phage display library

ASJC Scopus subject areas

  • Bioengineering

Cite this

Wang, C. H., Weng, C. H., Che, Y. J., Wang, K., & Lee, G. B. (2013). Cancer cell-specific oligopeptide selected by microfluidic system from a phage display library for ovarian cancer diagnosis. In 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 (pp. 1953-1955). (17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013; Vol. 3). Chemical and Biological Microsystems Society.

Cancer cell-specific oligopeptide selected by microfluidic system from a phage display library for ovarian cancer diagnosis. / Wang, Chih Hung; Weng, Chen Hsun; Che, Yu Jui; Wang, Kuan; Lee, Gwo Bin.

17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013. Chemical and Biological Microsystems Society, 2013. p. 1953-1955 (17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013; Vol. 3).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Wang, CH, Weng, CH, Che, YJ, Wang, K & Lee, GB 2013, Cancer cell-specific oligopeptide selected by microfluidic system from a phage display library for ovarian cancer diagnosis. in 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013. 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013, vol. 3, Chemical and Biological Microsystems Society, pp. 1953-1955, 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013, Freiburg, Germany, 10/27/13.
Wang CH, Weng CH, Che YJ, Wang K, Lee GB. Cancer cell-specific oligopeptide selected by microfluidic system from a phage display library for ovarian cancer diagnosis. In 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013. Chemical and Biological Microsystems Society. 2013. p. 1953-1955. (17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013).
Wang, Chih Hung ; Weng, Chen Hsun ; Che, Yu Jui ; Wang, Kuan ; Lee, Gwo Bin. / Cancer cell-specific oligopeptide selected by microfluidic system from a phage display library for ovarian cancer diagnosis. 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013. Chemical and Biological Microsystems Society, 2013. pp. 1953-1955 (17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013).
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