Calpain Activity and Toll-Like Receptor 4 Expression in Platelet Regulate Haemostatic Situation in Patients Undergoing Cardiac Surgery and Coagulation in Mice

Jui Chi Tsai, Yi Wen Lin, Chun Yao Huang, Feng Yen Lin, Chien Sung Tsai

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Human platelets express Toll-like receptors (TLR) 4. However, the mechanism by which TLR4 directly affects platelet aggregation and blood coagulation remains to be explored. Therefore, in this study, we evaluated the platelet TLR4 expression in patients who underwent CABG surgery; we explored the correlation between platelet TLR4 expression and the early outcomes in hospital of patients. Additionally, C57BL/6 and C57BL/6-TlrLPS-/- mice were used to explore the roles of platelet TLR4 in coagulation by platelet aggregometry and rotation thromboelastometry. In conclusion, our results highlight the important roles of TLR4 in blood coagulation and platelet function. Of clinical relevance, we also explored novel roles for platelet TLR4 that are associated with early outcomes in cardiac surgery.

Original languageEnglish
Article number484510
JournalMediators of Inflammation
Volume2014
DOIs
Publication statusPublished - 2014

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Toll-Like Receptor 4
Calpain
Hemostatics
Thoracic Surgery
Blood Platelets
Blood Coagulation
Thrombelastography
Platelet Aggregation

ASJC Scopus subject areas

  • Immunology
  • Cell Biology
  • Medicine(all)

Cite this

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abstract = "Human platelets express Toll-like receptors (TLR) 4. However, the mechanism by which TLR4 directly affects platelet aggregation and blood coagulation remains to be explored. Therefore, in this study, we evaluated the platelet TLR4 expression in patients who underwent CABG surgery; we explored the correlation between platelet TLR4 expression and the early outcomes in hospital of patients. Additionally, C57BL/6 and C57BL/6-TlrLPS-/- mice were used to explore the roles of platelet TLR4 in coagulation by platelet aggregometry and rotation thromboelastometry. In conclusion, our results highlight the important roles of TLR4 in blood coagulation and platelet function. Of clinical relevance, we also explored novel roles for platelet TLR4 that are associated with early outcomes in cardiac surgery.",
author = "Tsai, {Jui Chi} and Lin, {Yi Wen} and Huang, {Chun Yao} and Lin, {Feng Yen} and Tsai, {Chien Sung}",
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AU - Huang, Chun Yao

AU - Lin, Feng Yen

AU - Tsai, Chien Sung

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