Calcium influx inhibition: Possible mechanism of the negative effect of tetrahydropalmatine on left ventricular pressure in isolated rat heart

Paul Chan, Wen Ta Chiu, Yi Jen Chen, Pao Jean Wu, Juei Tang Cheng

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The active ingredient dl-tetrahydropalmatine (THP) isolated from the traditional Chinese herb Corydalis racemosa has been found to have antihypertensive effects. However, severe cardiac and neurological toxic effects were reported from using this herb for the treatment of pain. In an isolated perfused rat heart model, THP at the concentration of 100 μM was found to have a negative effect (-45%) on left ventricular pressure and this effect was produced concentration-dependently from concentrations lower than 50 μM. In isolated cardiomyocytes, radioactive calcium influx was also inhibited significantly by THP at the concentration of 100 μM and this effect was also in a concentration-dependent manner (-39%). In a patient with latent heart disease, the use of Corydalis should probably be detrimental, the toxic effect was probably due to calcium influx inhibition.

Original languageEnglish
Pages (from-to)340-342
Number of pages3
JournalPlanta Medica
Issue number4
Publication statusPublished - 1999
Externally publishedYes



  • Calcium antagonism
  • Cardiomyocyte
  • Corydalis racemosa
  • Langendorff
  • Papaveraceae
  • Tetrahydropalmatine

ASJC Scopus subject areas

  • Plant Science
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

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