Calcium influx inhibition: Possible mechanism of the negative effect of tetrahydropalmatine on left ventricular pressure in isolated rat heart

Paul Chan, Wen Ta Chiu, Yi Jen Chen, Pao Jean Wu, Juei Tang Cheng

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The active ingredient dl-tetrahydropalmatine (THP) isolated from the traditional Chinese herb Corydalis racemosa has been found to have antihypertensive effects. However, severe cardiac and neurological toxic effects were reported from using this herb for the treatment of pain. In an isolated perfused rat heart model, THP at the concentration of 100 μM was found to have a negative effect (-45%) on left ventricular pressure and this effect was produced concentration-dependently from concentrations lower than 50 μM. In isolated cardiomyocytes, radioactive calcium influx was also inhibited significantly by THP at the concentration of 100 μM and this effect was also in a concentration-dependent manner (-39%). In a patient with latent heart disease, the use of Corydalis should probably be detrimental, the toxic effect was probably due to calcium influx inhibition.

Original languageEnglish
Pages (from-to)340-342
Number of pages3
JournalPlanta Medica
Volume65
Issue number4
DOIs
Publication statusPublished - 1999
Externally publishedYes

Fingerprint

Corydalis
Ventricular Pressure
Rats
herbs
Poisons
heart
Calcium
calcium
antihypertensive effect
rats
heart diseases
active ingredients
pain
Antihypertensive Agents
Cardiac Myocytes
Heart Diseases
Pain
tetrahydropalmatine
Inhibition (Psychology)

Keywords

  • Calcium antagonism
  • Cardiomyocyte
  • Corydalis racemosa
  • Langendorff
  • Papaveraceae
  • Tetrahydropalmatine

ASJC Scopus subject areas

  • Plant Science
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Calcium influx inhibition : Possible mechanism of the negative effect of tetrahydropalmatine on left ventricular pressure in isolated rat heart. / Chan, Paul; Chiu, Wen Ta; Chen, Yi Jen; Wu, Pao Jean; Cheng, Juei Tang.

In: Planta Medica, Vol. 65, No. 4, 1999, p. 340-342.

Research output: Contribution to journalArticle

@article{fef9f6c4341544fea2b50ba6575505b8,
title = "Calcium influx inhibition: Possible mechanism of the negative effect of tetrahydropalmatine on left ventricular pressure in isolated rat heart",
abstract = "The active ingredient dl-tetrahydropalmatine (THP) isolated from the traditional Chinese herb Corydalis racemosa has been found to have antihypertensive effects. However, severe cardiac and neurological toxic effects were reported from using this herb for the treatment of pain. In an isolated perfused rat heart model, THP at the concentration of 100 μM was found to have a negative effect (-45{\%}) on left ventricular pressure and this effect was produced concentration-dependently from concentrations lower than 50 μM. In isolated cardiomyocytes, radioactive calcium influx was also inhibited significantly by THP at the concentration of 100 μM and this effect was also in a concentration-dependent manner (-39{\%}). In a patient with latent heart disease, the use of Corydalis should probably be detrimental, the toxic effect was probably due to calcium influx inhibition.",
keywords = "Calcium antagonism, Cardiomyocyte, Corydalis racemosa, Langendorff, Papaveraceae, Tetrahydropalmatine",
author = "Paul Chan and Chiu, {Wen Ta} and Chen, {Yi Jen} and Wu, {Pao Jean} and Cheng, {Juei Tang}",
year = "1999",
doi = "10.1055/s-1999-13998",
language = "English",
volume = "65",
pages = "340--342",
journal = "Planta Medica",
issn = "0032-0943",
publisher = "Georg Thieme Verlag",
number = "4",

}

TY - JOUR

T1 - Calcium influx inhibition

T2 - Possible mechanism of the negative effect of tetrahydropalmatine on left ventricular pressure in isolated rat heart

AU - Chan, Paul

AU - Chiu, Wen Ta

AU - Chen, Yi Jen

AU - Wu, Pao Jean

AU - Cheng, Juei Tang

PY - 1999

Y1 - 1999

N2 - The active ingredient dl-tetrahydropalmatine (THP) isolated from the traditional Chinese herb Corydalis racemosa has been found to have antihypertensive effects. However, severe cardiac and neurological toxic effects were reported from using this herb for the treatment of pain. In an isolated perfused rat heart model, THP at the concentration of 100 μM was found to have a negative effect (-45%) on left ventricular pressure and this effect was produced concentration-dependently from concentrations lower than 50 μM. In isolated cardiomyocytes, radioactive calcium influx was also inhibited significantly by THP at the concentration of 100 μM and this effect was also in a concentration-dependent manner (-39%). In a patient with latent heart disease, the use of Corydalis should probably be detrimental, the toxic effect was probably due to calcium influx inhibition.

AB - The active ingredient dl-tetrahydropalmatine (THP) isolated from the traditional Chinese herb Corydalis racemosa has been found to have antihypertensive effects. However, severe cardiac and neurological toxic effects were reported from using this herb for the treatment of pain. In an isolated perfused rat heart model, THP at the concentration of 100 μM was found to have a negative effect (-45%) on left ventricular pressure and this effect was produced concentration-dependently from concentrations lower than 50 μM. In isolated cardiomyocytes, radioactive calcium influx was also inhibited significantly by THP at the concentration of 100 μM and this effect was also in a concentration-dependent manner (-39%). In a patient with latent heart disease, the use of Corydalis should probably be detrimental, the toxic effect was probably due to calcium influx inhibition.

KW - Calcium antagonism

KW - Cardiomyocyte

KW - Corydalis racemosa

KW - Langendorff

KW - Papaveraceae

KW - Tetrahydropalmatine

UR - http://www.scopus.com/inward/record.url?scp=0033005439&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033005439&partnerID=8YFLogxK

U2 - 10.1055/s-1999-13998

DO - 10.1055/s-1999-13998

M3 - Article

C2 - 10364840

AN - SCOPUS:0033005439

VL - 65

SP - 340

EP - 342

JO - Planta Medica

JF - Planta Medica

SN - 0032-0943

IS - 4

ER -