Abstract
The active ingredient dl-tetrahydropalmatine (THP) isolated from the traditional Chinese herb Corydalis racemosa has been found to have antihypertensive effects. However, severe cardiac and neurological toxic effects were reported from using this herb for the treatment of pain. In an isolated perfused rat heart model, THP at the concentration of 100 μM was found to have a negative effect (-45%) on left ventricular pressure and this effect was produced concentration-dependently from concentrations lower than 50 μM. In isolated cardiomyocytes, radioactive calcium influx was also inhibited significantly by THP at the concentration of 100 μM and this effect was also in a concentration-dependent manner (-39%). In a patient with latent heart disease, the use of Corydalis should probably be detrimental, the toxic effect was probably due to calcium influx inhibition.
| Original language | English |
|---|---|
| Pages (from-to) | 340-342 |
| Number of pages | 3 |
| Journal | Planta Medica |
| Volume | 65 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1999 |
| Externally published | Yes |
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Keywords
- Calcium antagonism
- Cardiomyocyte
- Corydalis racemosa
- Langendorff
- Papaveraceae
- Tetrahydropalmatine
ASJC Scopus subject areas
- Plant Science
- Drug Discovery
- Organic Chemistry
- Pharmacology
Cite this
Calcium influx inhibition : Possible mechanism of the negative effect of tetrahydropalmatine on left ventricular pressure in isolated rat heart. / Chan, Paul; Chiu, Wen Ta; Chen, Yi Jen; Wu, Pao Jean; Cheng, Juei Tang.
In: Planta Medica, Vol. 65, No. 4, 1999, p. 340-342.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Calcium influx inhibition
T2 - Possible mechanism of the negative effect of tetrahydropalmatine on left ventricular pressure in isolated rat heart
AU - Chan, Paul
AU - Chiu, Wen Ta
AU - Chen, Yi Jen
AU - Wu, Pao Jean
AU - Cheng, Juei Tang
PY - 1999
Y1 - 1999
N2 - The active ingredient dl-tetrahydropalmatine (THP) isolated from the traditional Chinese herb Corydalis racemosa has been found to have antihypertensive effects. However, severe cardiac and neurological toxic effects were reported from using this herb for the treatment of pain. In an isolated perfused rat heart model, THP at the concentration of 100 μM was found to have a negative effect (-45%) on left ventricular pressure and this effect was produced concentration-dependently from concentrations lower than 50 μM. In isolated cardiomyocytes, radioactive calcium influx was also inhibited significantly by THP at the concentration of 100 μM and this effect was also in a concentration-dependent manner (-39%). In a patient with latent heart disease, the use of Corydalis should probably be detrimental, the toxic effect was probably due to calcium influx inhibition.
AB - The active ingredient dl-tetrahydropalmatine (THP) isolated from the traditional Chinese herb Corydalis racemosa has been found to have antihypertensive effects. However, severe cardiac and neurological toxic effects were reported from using this herb for the treatment of pain. In an isolated perfused rat heart model, THP at the concentration of 100 μM was found to have a negative effect (-45%) on left ventricular pressure and this effect was produced concentration-dependently from concentrations lower than 50 μM. In isolated cardiomyocytes, radioactive calcium influx was also inhibited significantly by THP at the concentration of 100 μM and this effect was also in a concentration-dependent manner (-39%). In a patient with latent heart disease, the use of Corydalis should probably be detrimental, the toxic effect was probably due to calcium influx inhibition.
KW - Calcium antagonism
KW - Cardiomyocyte
KW - Corydalis racemosa
KW - Langendorff
KW - Papaveraceae
KW - Tetrahydropalmatine
UR - http://www.scopus.com/inward/record.url?scp=0033005439&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033005439&partnerID=8YFLogxK
U2 - 10.1055/s-1999-13998
DO - 10.1055/s-1999-13998
M3 - Article
VL - 65
SP - 340
EP - 342
JO - Planta Medica
JF - Planta Medica
SN - 0032-0943
IS - 4
ER -