Calcium influx inhibition: Possible mechanism of the negative effect of tetrahydropalmatine on left ventricular pressure in isolated rat heart

Paul Chan; Wen Ta Chiu; Yi Jen Chen; Pao Jean Wu; Juei Tang Cheng

doi:10.1055/s-1999-13998

Calcium influx inhibition: Possible mechanism of the negative effect of tetrahydropalmatine on left ventricular pressure in isolated rat heart

Paul Chan, Wen Ta Chiu, Yi Jen Chen, Pao Jean Wu, Juei Tang Cheng

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

The active ingredient dl-tetrahydropalmatine (THP) isolated from the traditional Chinese herb Corydalis racemosa has been found to have antihypertensive effects. However, severe cardiac and neurological toxic effects were reported from using this herb for the treatment of pain. In an isolated perfused rat heart model, THP at the concentration of 100 μM was found to have a negative effect (-45%) on left ventricular pressure and this effect was produced concentration-dependently from concentrations lower than 50 μM. In isolated cardiomyocytes, radioactive calcium influx was also inhibited significantly by THP at the concentration of 100 μM and this effect was also in a concentration-dependent manner (-39%). In a patient with latent heart disease, the use of Corydalis should probably be detrimental, the toxic effect was probably due to calcium influx inhibition.

Original language	English
Pages (from-to)	340-342
Number of pages	3
Journal	Planta Medica
Volume	65
Issue number	4
DOIs	https://doi.org/10.1055/s-1999-13998
Publication status	Published - 1999
Externally published	Yes

Keywords

Calcium antagonism
Cardiomyocyte
Corydalis racemosa
Langendorff
Papaveraceae
Tetrahydropalmatine

ASJC Scopus subject areas

Plant Science
Drug Discovery
Organic Chemistry
Pharmacology

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title = "Calcium influx inhibition: Possible mechanism of the negative effect of tetrahydropalmatine on left ventricular pressure in isolated rat heart",

abstract = "The active ingredient dl-tetrahydropalmatine (THP) isolated from the traditional Chinese herb Corydalis racemosa has been found to have antihypertensive effects. However, severe cardiac and neurological toxic effects were reported from using this herb for the treatment of pain. In an isolated perfused rat heart model, THP at the concentration of 100 μM was found to have a negative effect (-45%) on left ventricular pressure and this effect was produced concentration-dependently from concentrations lower than 50 μM. In isolated cardiomyocytes, radioactive calcium influx was also inhibited significantly by THP at the concentration of 100 μM and this effect was also in a concentration-dependent manner (-39%). In a patient with latent heart disease, the use of Corydalis should probably be detrimental, the toxic effect was probably due to calcium influx inhibition.",

keywords = "Calcium antagonism, Cardiomyocyte, Corydalis racemosa, Langendorff, Papaveraceae, Tetrahydropalmatine",

author = "Paul Chan and Chiu, {Wen Ta} and Chen, {Yi Jen} and Wu, {Pao Jean} and Cheng, {Juei Tang}",

year = "1999",

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T2 - Possible mechanism of the negative effect of tetrahydropalmatine on left ventricular pressure in isolated rat heart

AU - Chan, Paul

AU - Chiu, Wen Ta

AU - Chen, Yi Jen

AU - Wu, Pao Jean

AU - Cheng, Juei Tang

PY - 1999

Y1 - 1999

N2 - The active ingredient dl-tetrahydropalmatine (THP) isolated from the traditional Chinese herb Corydalis racemosa has been found to have antihypertensive effects. However, severe cardiac and neurological toxic effects were reported from using this herb for the treatment of pain. In an isolated perfused rat heart model, THP at the concentration of 100 μM was found to have a negative effect (-45%) on left ventricular pressure and this effect was produced concentration-dependently from concentrations lower than 50 μM. In isolated cardiomyocytes, radioactive calcium influx was also inhibited significantly by THP at the concentration of 100 μM and this effect was also in a concentration-dependent manner (-39%). In a patient with latent heart disease, the use of Corydalis should probably be detrimental, the toxic effect was probably due to calcium influx inhibition.

AB - The active ingredient dl-tetrahydropalmatine (THP) isolated from the traditional Chinese herb Corydalis racemosa has been found to have antihypertensive effects. However, severe cardiac and neurological toxic effects were reported from using this herb for the treatment of pain. In an isolated perfused rat heart model, THP at the concentration of 100 μM was found to have a negative effect (-45%) on left ventricular pressure and this effect was produced concentration-dependently from concentrations lower than 50 μM. In isolated cardiomyocytes, radioactive calcium influx was also inhibited significantly by THP at the concentration of 100 μM and this effect was also in a concentration-dependent manner (-39%). In a patient with latent heart disease, the use of Corydalis should probably be detrimental, the toxic effect was probably due to calcium influx inhibition.

KW - Calcium antagonism

KW - Cardiomyocyte

KW - Corydalis racemosa

KW - Langendorff

KW - Papaveraceae

KW - Tetrahydropalmatine

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SN - 0032-0943

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ER -

Calcium influx inhibition: Possible mechanism of the negative effect of tetrahydropalmatine on left ventricular pressure in isolated rat heart

Abstract

Keywords

ASJC Scopus subject areas

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