Caffeic acid as active principle from the fruit of Xanthium strumarium to lower plasma glucose in diabetic rats

Feng L. Hsu, Yun Chueh Chen, Juei Tang Cheng

Research output: Contribution to journalArticle

133 Citations (Scopus)

Abstract

The antihyperglycemic effect of caffeic acid, one of the phenolic compounds contained in the fruit of Xanthium strumarium, was investigated. After an intravenous injection of caffeic acid into diabetic rats of both streptozotocin-induced and insulin-resistant models, a dose-dependent decrease of plasma glucose was observed. However, a similar effect was not produced in normal rats. An insulin-independent action of caffeic acid can thus be considered. Otherwise, this compound reduced the elevation of plasma glucose level in insulin-resistant rats receiving a glucose challenge test. Also, glucose uptake into the isolated adipocytes was raised by caffeic acid in a concentration-dependent manner. Increase of glucose utilization by caffeic acid seems to be responsible for the lowering of plasma glucose.

Original languageEnglish
Pages (from-to)228-230
Number of pages3
JournalPlanta Medica
Volume66
Issue number3
DOIs
Publication statusPublished - 2000

Fingerprint

Xanthium
Xanthium strumarium
caffeic acid
Fruits
Rats
Fruit
Plasmas
Glucose
glucose
fruits
rats
Insulin
insulin resistance
glycemic effect
streptozotocin
Streptozocin
adipocytes
Hypoglycemic Agents
Adipocytes
intravenous injection

Keywords

  • Antihyperglycemic effect
  • Caffeic acid
  • Compositae
  • Glucose challenge test
  • Glucose uptake
  • Insulin-independent action
  • Xanthium strumarium

ASJC Scopus subject areas

  • Plant Science
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Cite this

Caffeic acid as active principle from the fruit of Xanthium strumarium to lower plasma glucose in diabetic rats. / Hsu, Feng L.; Chen, Yun Chueh; Cheng, Juei Tang.

In: Planta Medica, Vol. 66, No. 3, 2000, p. 228-230.

Research output: Contribution to journalArticle

Hsu, Feng L. ; Chen, Yun Chueh ; Cheng, Juei Tang. / Caffeic acid as active principle from the fruit of Xanthium strumarium to lower plasma glucose in diabetic rats. In: Planta Medica. 2000 ; Vol. 66, No. 3. pp. 228-230.
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