C-reactive protein predicts systolic blood pressure and pulse pressure but not diastolic blood pressure

The cardiovascular disease risk factors two-township study

Shao Yuan Chuang, Pai Feng Hsu, Hsing Yi Chang, Chyi Huey Bai, Wen Ting Yeh, Harn Wen Pan

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

OBJECTIVEInflammation has been associated with cardiovascular events and mortality, using C-reactive protein (CRP) as a marker. We examined whether the baseline serum concentration of CRP can independently predict the development of hypertension or future systolic or diastolic blood pressure (BP) in a community-based population in Taiwan. Methods A study population sample was recruited in cycle 2 (1990-1993) of the CardioVascular Disease risk FACtors Two-township Study (CVDFACTS) and was followed to 1994-1997. A total of 2,113 nondiabetic adults with normal BP were enrolled for the study of incident hypertension. Hypertension was defined as a systolic blood pressure (SBP) ≥ 140mm Hg, a diastolic blood pressure (DBP) ≥ 90mm Hg, or the use of antihypertensive drugs. Cox regression and linear regression analyses were used to evaluate the association between baseline serum concentrations of CRP measured with a high-sensitivity assay and the development of hypertension and future SBP/DBP and pulse pressure (PP).RESULTSDuring the follow-up period of a median of 3.27 years, 145 participants developed incident hypertension. The incidence rates of hypertension by tertile of increasing CRP were 9.3, 19.0, and 33.0 per 1,000 person-years (P for trend <0.01). In the multivariate model adjusted for age, gender, and prehypertension, baseline CRP remained significantly predictive of incident hypertension. The concentration of CRP was associated with SBP and PP, but not with DBP.CONCLUSIONInflammation is associated with future SBP in the Taiwanese population.

Original languageEnglish
Pages (from-to)657-664
Number of pages8
JournalAmerican Journal of Hypertension
Volume26
Issue number5
DOIs
Publication statusPublished - May 2013

Fingerprint

C-Reactive Protein
Cardiovascular Diseases
Blood Pressure
Hypertension
Prehypertension
Population
Serum
Taiwan
Antihypertensive Agents

Keywords

  • blood pressure
  • C-reactive protein
  • hypertension
  • prospective study
  • pulse pressure
  • systolic blood pressure

ASJC Scopus subject areas

  • Internal Medicine

Cite this

C-reactive protein predicts systolic blood pressure and pulse pressure but not diastolic blood pressure : The cardiovascular disease risk factors two-township study. / Chuang, Shao Yuan; Hsu, Pai Feng; Chang, Hsing Yi; Bai, Chyi Huey; Yeh, Wen Ting; Pan, Harn Wen.

In: American Journal of Hypertension, Vol. 26, No. 5, 05.2013, p. 657-664.

Research output: Contribution to journalArticle

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N2 - OBJECTIVEInflammation has been associated with cardiovascular events and mortality, using C-reactive protein (CRP) as a marker. We examined whether the baseline serum concentration of CRP can independently predict the development of hypertension or future systolic or diastolic blood pressure (BP) in a community-based population in Taiwan. Methods A study population sample was recruited in cycle 2 (1990-1993) of the CardioVascular Disease risk FACtors Two-township Study (CVDFACTS) and was followed to 1994-1997. A total of 2,113 nondiabetic adults with normal BP were enrolled for the study of incident hypertension. Hypertension was defined as a systolic blood pressure (SBP) ≥ 140mm Hg, a diastolic blood pressure (DBP) ≥ 90mm Hg, or the use of antihypertensive drugs. Cox regression and linear regression analyses were used to evaluate the association between baseline serum concentrations of CRP measured with a high-sensitivity assay and the development of hypertension and future SBP/DBP and pulse pressure (PP).RESULTSDuring the follow-up period of a median of 3.27 years, 145 participants developed incident hypertension. The incidence rates of hypertension by tertile of increasing CRP were 9.3, 19.0, and 33.0 per 1,000 person-years (P for trend <0.01). In the multivariate model adjusted for age, gender, and prehypertension, baseline CRP remained significantly predictive of incident hypertension. The concentration of CRP was associated with SBP and PP, but not with DBP.CONCLUSIONInflammation is associated with future SBP in the Taiwanese population.

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