C-reactive protein concentration as a significant correlate for metabolic syndrome: A Chinese population-based study

Tsan Yang, Chi Hong Chu, Po Chien Hsieh, Chih Hsung Hsu, Yu Ching Chou, Shih Hsien Yang, Chyi-Huey Bai, San Lin You, Lee Ching Hwang, Tieh Chi Chung, Chien An Sun

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Abstract

Increasing evidence suggests that chronic, low-grade inflammation may be a common soil involving the pathogenesis of metabolic syndrome (MetS) and cardiovascular disease. We examined the association between C-reactive protein (CRP) concentration, an extensively studied biomarker of low-grade inflammation, and the MetS in a representative sample of Chinese adults in Taiwan. We performed a cross-sectional analysis of data from 4234 subjects [mean (±SD) age, 47.1 (±18.2) years; 46.4 % males] who participated in a population-based survey on prevalences of hypertension, hyperglycemia, and hyperlipidemia in Taiwan. CRP levels were measured by the immunoturbidimetric CRP-latex high-sensitivity assay. The MetS was defined by an unified criteria set by several major organizations. Odds ratios (ORs) and 95 % confidence intervals (CIs) were calculated with logistic regression model. Overall, there were 938 subjects with MetS among 4,234 participants, resulting in a prevalence rate of 22.1 %. A significantly progressive increase in the prevalence of MetS across quartiles of CRP was observed (p for trend

Original languageEnglish
Pages (from-to)351-359
Number of pages9
JournalEndocrine
Volume43
Issue number2
DOIs
Publication statusPublished - Apr 2013

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Keywords

  • C-reactive protein
  • Chinese
  • Cross-sectional study
  • Inflammation
  • Metabolic syndrome

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Yang, T., Chu, C. H., Hsieh, P. C., Hsu, C. H., Chou, Y. C., Yang, S. H., Bai, C-H., You, S. L., Hwang, L. C., Chung, T. C., & Sun, C. A. (2013). C-reactive protein concentration as a significant correlate for metabolic syndrome: A Chinese population-based study. Endocrine, 43(2), 351-359. https://doi.org/10.1007/s12020-012-9743-7