C 60 fullerene derivatized nanoparticles and their application to therapeutics

Chun-Mao Lin, Tan Yi Lu

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Fullerenes can be formed into many new materials and devices. They have a wide range of applications in medicine, electronics, biomaterials, and energy production. An overview of the nanostructure and the physical and chemical characteristics of fullerene-drug derivatives is given. The biological behavior of fullerene derivatives shows their potential to medical application fields because C 60 is rapidly absorbed by tissues and is excreted through urinary tract and enterons, which reveals low toxicity in vitro and in vivo studies. Nanomedicine has become one of the most promising areas of nanotechnology, while many have claimed its therapeutic use against cancer, human immunodeficiency virus (HIV), and neurodegenerative disorders. Water-soluble C 60 fullerene derivatives that come from chemical modification largely enhance the biological efficacy. The blood-brain barrier (BBB) is a physical barrier composed of endothelial tight junctions that restrict the paracellular permeability. A major challenge facing neuropharmacology is to find compounds that can be delivered into the brain through the bloodstream. Fullerene C 60 was demonstratively able to cross the BBB by hybridizing a biologically active moiety dyad, which provides a promising clue as a pharmacological therapy of neural disorders.

Original languageEnglish
Pages (from-to)105-113
Number of pages9
JournalRecent Patents on Nanotechnology
Volume6
Issue number2
Publication statusPublished - Jun 2012

Keywords

  • Antioxidant
  • Apoptosis
  • Autophagy
  • Blood brain barrier (BBB)
  • Cytotoxicity
  • Fullerene
  • Fullerene dyad
  • Fulleropyrrolidine-xanthine dyad
  • Graphene
  • Nanomedicine
  • Nanoparticle
  • Nanotechnology
  • Neurodegenerative disease
  • Neuroprotective
  • PEG-C -3
  • PTX-C -2

ASJC Scopus subject areas

  • Engineering(all)
  • Materials Science(all)
  • Condensed Matter Physics

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