Abstract
Severe bronchopulmonary dysplasia (BPD) is common disease, especially for the tiniest infants with gestational age <27 weeks whose mothers did not receive adequate antenatal steroid prophylaxis. Systemic corticosteroids have been demonstrated to be effective in the prevention of BPD, but their adverse effects prevent routine use. The results of inhaled steroid therapy in intubated premature infants are disappointing. In a pilot study, infants in the treatment group who received early intratracheal instillation of budesonide by using surfactant as a vehicle required significantly less ventilator supportduring the first 2 weeks than infants in the control group. The combined outcome of deaths or BPD was significantly lower in the treatment group than in the control group. No clinically significant adverse effects from the treatment were observed during the study. The results are encouraging, and a large sample multicenter trial is warranted.
| Original language | English |
|---|---|
| Journal | NeoReviews |
| Volume | 13 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Aug 2012 |
Fingerprint
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
Cite this
Budesonide therapy in preterm infants to prevent bronchopulmonary dysplasia. / Wu, Shou Y.; Chen, Chung M.; Kuo, Yung T.; Yeh, Tsu F.
In: NeoReviews, Vol. 13, No. 8, 08.2012.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Budesonide therapy in preterm infants to prevent bronchopulmonary dysplasia
AU - Wu, Shou Y.
AU - Chen, Chung M.
AU - Kuo, Yung T.
AU - Yeh, Tsu F.
PY - 2012/8
Y1 - 2012/8
N2 - Severe bronchopulmonary dysplasia (BPD) is common disease, especially for the tiniest infants with gestational age <27 weeks whose mothers did not receive adequate antenatal steroid prophylaxis. Systemic corticosteroids have been demonstrated to be effective in the prevention of BPD, but their adverse effects prevent routine use. The results of inhaled steroid therapy in intubated premature infants are disappointing. In a pilot study, infants in the treatment group who received early intratracheal instillation of budesonide by using surfactant as a vehicle required significantly less ventilator supportduring the first 2 weeks than infants in the control group. The combined outcome of deaths or BPD was significantly lower in the treatment group than in the control group. No clinically significant adverse effects from the treatment were observed during the study. The results are encouraging, and a large sample multicenter trial is warranted.
AB - Severe bronchopulmonary dysplasia (BPD) is common disease, especially for the tiniest infants with gestational age <27 weeks whose mothers did not receive adequate antenatal steroid prophylaxis. Systemic corticosteroids have been demonstrated to be effective in the prevention of BPD, but their adverse effects prevent routine use. The results of inhaled steroid therapy in intubated premature infants are disappointing. In a pilot study, infants in the treatment group who received early intratracheal instillation of budesonide by using surfactant as a vehicle required significantly less ventilator supportduring the first 2 weeks than infants in the control group. The combined outcome of deaths or BPD was significantly lower in the treatment group than in the control group. No clinically significant adverse effects from the treatment were observed during the study. The results are encouraging, and a large sample multicenter trial is warranted.
UR - http://www.scopus.com/inward/record.url?scp=84865659819&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84865659819&partnerID=8YFLogxK
U2 - 10.1542/neo.13-8-e467
DO - 10.1542/neo.13-8-e467
M3 - Article
VL - 13
JO - Pediatrics in Review
JF - Pediatrics in Review
SN - 0191-9601
IS - 8
ER -