Brown Seaweed Fucoidan Inhibits Cancer Progression by Dual Regulation of mir-29c/ADAM12 and miR-17-5p/PTEN Axes in Human Breast Cancer Cells

Szu Yuan Wu, Ming De Yan, Alexander T H Wu, Kevin Sheng Po Yuan, Shing Hwa Liu

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

In this study, we observed that brown seaweed fucoidan inhibited human breast cancer progression by upregulating microRNA (miR)-29c and downregulating miR-17-5p, thereby suppressing their target genes, a disintegrin and metalloproteinase 12 (ADAM12) and phosphatase and tensin homolog (PTEN), respectively. Moreover, fucoidan reduced the luciferase activity of 3'-untranslated region reporter; treatment of cells with the miR-29c mimic or miR-17-5p inhibitor also produced similar results. These effects of fucoidan inhibited the epithelial-mesenchymal transition in breast cancer cells, as evidenced by an increase in E-cadherin and a drop in N-cadherin, and inhibited breast cancer cell survival, as evidenced by the activation of the phosphoinositide 3-kinase/Akt pathway. Taken together, these findings demonstrate that fucoidan inhibits breast cancer progression by regulating the miR-29c/ADAM12 and miR-17-5p/PTEN axes. Fucoidan is a potential chemopreventive/chemotherapeutic agent for breast cancer.

Original languageEnglish
Pages (from-to)2408-2419
Number of pages12
JournalJournal of Cancer
Volume7
Issue number15
DOIs
Publication statusPublished - 2016

Keywords

  • ADAM12
  • Breast cancer cells
  • Fucoidan
  • MiR-17-5p
  • MiR-29c
  • PTEN

ASJC Scopus subject areas

  • Oncology

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