Brief report-Human embryonic stem cell-derived mesenchymal progenitors possess strong immunosuppressive effects toward natural killer cells as well as T lymphocytes

B. Linju Yen, Jung Chang Chan, Ko Jiunn Liu, Chang Chen Yao, Hsin I. Hu, Bai Chi-Huey, Men Luh Yen

Research output: Contribution to journalArticlepeer-review

83 Citations (Scopus)

Abstract

The derivation of mesenchymal progenitors from human embryonic stem cells (hESCs) has recently been reported. We studied the immune characteristics of these hESC-de rived mesenchymal progenitors (EMPs) and their interactions with T lymphocytes and natural killer cells (NKs), two populations of lymphocytes with important roles in transplantation immunology. EMPs express a number of bone marrow mesenchymal stromal cell (BMMSC) markers, as well as the hESC marker SSEA-4. Immunologically, EMPs do not express HLA-DR or costimulatory molecules. On the other hand, HLA-G, a nonclassic MHC I protein involved in mediating maternal-fetal tolerance, can be found on the surface of EMPs, and its expression is increased after interferon-γ stimulation. EMPs can suppress CD4+ or CD8+ lymphocyte proliferation, similar to BMMSCs. However, EMPs are more resistant to NK-mediated lysis than BMMSCs and can suppress the cytotoxic effects of activated NKs, as well as downregu-lating the NK-activating receptors NKp30 and NKp46. With their broad immunosuppressive properties, EMPs may represent a new potential cell source for therapeutic use.

Original languageEnglish
Pages (from-to)451-456
Number of pages6
JournalStem Cells
Volume27
Issue number2
DOIs
Publication statusPublished - Feb 2009

Keywords

  • HLA-G natural killer cells
  • Human embryonic stem cells
  • Immunosuppression
  • Mesenchymal stromal cells
  • T lymphocytes

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology
  • Molecular Medicine

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