Briaviolides k-n, new briarane-type diterpenoids from cultured octocoral briareum violaceum

Jing Hao Xu, Kuei Hung Lai, Yin Di Su, Yu Chia Chang, Bo Rong Peng, Anders Backlund, Zhi Hong Wen, Ping Jyun Sung

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Four new briarane diterpenoids, briaviolides K-N (1-4), have been obtained from the cultured-type octocoral Briareum violaceum. Using a spectroscopic approach, the structures of briaranes 1-4 were identified. This study employed an in vitro model of lipopolysaccharide (LPS)-induced inflammation in the murine macrophage RAW 264.7 cell line, and found that among the four briaranes, briarane 2 possessed anti-inflammatory activity against inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein expressions in cells. In addition, principal component analysis using the chemical global positioning system (ChemGPS) for natural products (ChemGPS-NP) was employed in order to analyze the structure-activity relationship (SAR), and the results indicated that the ring conformation of the compound has a leading role in suppressing the expressions of pro-inflammatory iNOS and COX-2 proteins in macrophages.

Original languageEnglish
Article number75
JournalMarine Drugs
Volume16
Issue number3
DOIs
Publication statusPublished - 2018
Externally publishedYes

Keywords

  • Briarane
  • Briareum violaceum
  • Briaviolide
  • ChemGPS-NP
  • COX-2
  • INOS

ASJC Scopus subject areas

  • Drug Discovery

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  • Cite this

    Xu, J. H., Lai, K. H., Su, Y. D., Chang, Y. C., Peng, B. R., Backlund, A., Wen, Z. H., & Sung, P. J. (2018). Briaviolides k-n, new briarane-type diterpenoids from cultured octocoral briareum violaceum. Marine Drugs, 16(3), [75]. https://doi.org/10.3390/md16030075