Breakdown in the temporal and spatial organization of spontaneous brain activity during general anesthesia

Jianfeng Zhang, Zirui Huang, Yali Chen, Jun Zhang, Diana Ghinda, Yuliya Nikolova, Jinsong Wu, Jianghui Xu, Wenjie Bai, Ying Mao, Zhong Yang, Niall Duncan, Pengmin Qin, Hao Wang, Bing Chen, Xuchu Weng, Georg Northoff

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Which temporal features that can characterize different brain states (i.e., consciousness or unconsciousness) is a fundamental question in the neuroscience of consciousness. Using resting-state functional magnetic resonance imaging (rs-fMRI), we investigated the spatial patterns of two temporal features: the long-range temporal correlations (LRTCs), measured by power-law exponent (PLE), and temporal variability, measured by standard deviation (SD) during wakefulness and anesthetic-induced unconsciousness. We found that both PLE and SD showed global reductions across the whole brain during anesthetic state comparing to wakefulness. Importantly, the relationship between PLE and SD was altered in anesthetic state, in terms of a spatial "decoupling." This decoupling was mainly driven by a spatial pattern alteration of the PLE, rather than the SD, in the anesthetic state. Our results suggest differential physiological grounds of PLE and SD and highlight the functional importance of the topographical organization of LRTCs in maintaining an optimal spatiotemporal configuration of the neural dynamics during normal level of consciousness. The central role of the spatial distribution of LRTCs, reflecting temporo-spatial nestedness, may support the recently introduced temporo-spatial theory of consciousness (TTC).

Original languageEnglish
Pages (from-to)2035-2046
Number of pages12
JournalHuman Brain Mapping
Volume39
Issue number5
DOIs
Publication statusPublished - May 1 2018

Keywords

  • anesthesia
  • consciousness
  • long-range temporal correlations
  • resting-state fMRI
  • temporal variability

ASJC Scopus subject areas

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology

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  • Cite this

    Zhang, J., Huang, Z., Chen, Y., Zhang, J., Ghinda, D., Nikolova, Y., Wu, J., Xu, J., Bai, W., Mao, Y., Yang, Z., Duncan, N., Qin, P., Wang, H., Chen, B., Weng, X., & Northoff, G. (2018). Breakdown in the temporal and spatial organization of spontaneous brain activity during general anesthesia. Human Brain Mapping, 39(5), 2035-2046. https://doi.org/10.1002/hbm.23984