Breadfruit flavonoid derivatives attenuate advanced glycation end products (AGEs)-enhanced colon malignancy in HCT116 cancer cells

Jer An Lin, Chi Hao Wu, Gow Chin Yen

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Advanced glycation end products (AGEs)-evoked response is an important event in colon tumorigenesis. The aim of this study was to investigate the effect of flavonoid derivatives isolated from breadfruit Artocarpus communis on AGEs-enhanced colon malignancy in vitro. According to results, glyceraldehyde-derived AGEs (AGE; 200 μg/mL) enhanced the malignancy of HCT116 colon cancer cells; however, treatment with flavonoid derivatives (2′,4,4′-trihydroxy-3′-[6-hydroxy-3,7-dimethyl-2(E),7-octadienyl]chalcone, AC-a; 6-geranyl-4′,7-dihydroxyflavanone, AC-b; 5′-geranyl-2′,4,4′-trihydroxydihydrochalcone, AC-c; 6-geranyl-4′,5,7-trihydroxyflavanone, AC-d) inhibited these changes. These flavonoid derivative-induced biological actions are associated with the modulation of MAPK/NF-κB cascades and translocation of STAT3 and β-catenin. Furthermore, we first found that proliferation of HCT116 cells increased when cultured in conditioned media from AGE-induced THP-1 monocytes (AGE-CM), which may be closely related to the action of AGE-stimulated pro-carcinogenic factors in monocytes; however, flavonoid derivatives retarded aforementioned AGE-CM-evoked phenomena. In conclusion, our study first demonstrates that flavonoid derivatives show great potential in ameliorating AGE-enhanced colon malignancy.

Original languageEnglish
Pages (from-to)248-254
Number of pages7
JournalJournal of Functional Foods
Volume31
DOIs
Publication statusPublished - Apr 1 2017

Keywords

  • Advanced glycation end products
  • Colon malignancy
  • Flavonoid derivatives
  • HCT116 colon cancer cells
  • THP-1 monocytes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science
  • Nutrition and Dietetics

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