Breadfruit flavonoid derivatives attenuate advanced glycation end products (AGEs)-enhanced colon malignancy in HCT116 cancer cells

Jer An Lin, Chi Hao Wu, Gow Chin Yen

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Advanced glycation end products (AGEs)-evoked response is an important event in colon tumorigenesis. The aim of this study was to investigate the effect of flavonoid derivatives isolated from breadfruit Artocarpus communis on AGEs-enhanced colon malignancy in vitro. According to results, glyceraldehyde-derived AGEs (AGE; 200 μg/mL) enhanced the malignancy of HCT116 colon cancer cells; however, treatment with flavonoid derivatives (2′,4,4′-trihydroxy-3′-[6-hydroxy-3,7-dimethyl-2(E),7-octadienyl]chalcone, AC-a; 6-geranyl-4′,7-dihydroxyflavanone, AC-b; 5′-geranyl-2′,4,4′-trihydroxydihydrochalcone, AC-c; 6-geranyl-4′,5,7-trihydroxyflavanone, AC-d) inhibited these changes. These flavonoid derivative-induced biological actions are associated with the modulation of MAPK/NF-κB cascades and translocation of STAT3 and β-catenin. Furthermore, we first found that proliferation of HCT116 cells increased when cultured in conditioned media from AGE-induced THP-1 monocytes (AGE-CM), which may be closely related to the action of AGE-stimulated pro-carcinogenic factors in monocytes; however, flavonoid derivatives retarded aforementioned AGE-CM-evoked phenomena. In conclusion, our study first demonstrates that flavonoid derivatives show great potential in ameliorating AGE-enhanced colon malignancy.

Original languageEnglish
Pages (from-to)248-254
Number of pages7
JournalJournal of Functional Foods
Volume31
DOIs
Publication statusPublished - Apr 1 2017

Fingerprint

Artocarpus
breadfruits
HCT116 Cells
Advanced Glycosylation End Products
Flavonoids
colon
Colon
flavonoids
monocytes
Monocytes
Neoplasms
Artocarpus altilis
glyceraldehyde
Glyceraldehyde
Chalcone
Catenins
chalcone
carcinogens
Conditioned Culture Medium
colorectal neoplasms

Keywords

  • Advanced glycation end products
  • Colon malignancy
  • Flavonoid derivatives
  • HCT116 colon cancer cells
  • THP-1 monocytes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science
  • Nutrition and Dietetics

Cite this

Breadfruit flavonoid derivatives attenuate advanced glycation end products (AGEs)-enhanced colon malignancy in HCT116 cancer cells. / Lin, Jer An; Wu, Chi Hao; Yen, Gow Chin.

In: Journal of Functional Foods, Vol. 31, 01.04.2017, p. 248-254.

Research output: Contribution to journalArticle

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