Brain tumors diagnosed in the first year of life in five Far-Eastern countries - Statistical analysis of 307 cases

S. Oi, S. Matsumoto, J. U. Choi, J. K. Kang, T. Wong, C. Wang, T. S.T. Chan

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

A statistical survey is presented of brain tumors diagnosed in the first year of life (from five Far-Eastern countries) in relation to the racial differences in tumor types, congenital factors, and general clinical features. Of the 307 cases collected, 262 were verified histologically, and astrocytomas comprised 23.3%, medulloblastomas 17.2%, ependymomas 11.1%, choroid plexus papillomas 10.7%, teratomas 8.4%, primitive neuroectodermal tumors 4.2%, meningiomas 2.3%, and others 22.9%. There were statistically significant racial differences in comparison with the worldwide survey done by the International Society for Pediatric Neurosurgery Education Committee (1987) on the same subject. In the Far-Eastern population, medulloblastoma and teratoma were more common (P<0.05), whereas astrocytoma was less frequent (P<0.01) than reported in the worldwide survey. The malformative factors were suggested in 18 cases in which various associated congential anomalies were observed. Vascular anomalous lesions, mostly in the extracranial organs, were most common, comprising 61.1% of the associated malformations. Hereditary factors were less commonly demonstrated in these tumors than were anomalies in the major congenital central nervous system. Among the 307 cases, there was one instance (0.3%) of nearly identical tumors occurring in twin brothers. The specific clinical manifestations of brain tumors involving the immature brain were again apparent in this survey, as were the poor survival rates and poor functional prognosis.

Original languageEnglish
Pages (from-to)79-85
Number of pages7
JournalChild's Nervous System
Volume6
Issue number2
DOIs
Publication statusPublished - Mar 1990
Externally publishedYes

Keywords

  • Brain tumors
  • Congenital factors
  • Cooperative survey
  • Far-Eastern countries
  • Neonates and infants
  • Racial differences

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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