Brain, the last fortress of sarcoma

Similar dismal outcome but discrepancy of timing of brain metastasis in bone and soft tissue sarcoma

Yi Sheng Chou, Chun Yu Liu, Wei Ming Chen, Tain Hsiung Chen, Paul Chih Hsueh Chen, Hung Ta Hondar Wu, Cheng Ying Shiau, Yu Chung Wu, Chien Lin Liu, Ta Chung Chao, Cheng Hwai Tzeng, Tai-Tong Wong, Chueh Chuan Yen

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background and Objective Brain metastasis is a rare but dismal event in sarcomas. However, the pattern of occurrence and the prognostic factors associated with post-brain metastasis survival (PBMS) are not yet well-characterized. Methods Sarcoma patients treated at one institute within 10-year period were retrospectively reviewed and those with brain metastasis were identified. The incidence of brain metastasis was demonstrated by case per person-years and cumulative incidence curves. Univariate factors associated with PBMS were analyzed. Results Among 611 sarcoma patients, 20 (3.3%) developed brain metastasis. Alveolar soft part sarcoma (ASPS) and osteosarcoma were the most common subtypes. Overall, the cumulative incidence was 3.9% at 5 years and 8.4% at 10 years. However, the incidence in STS patients continued to rise up to 10 years after primary diagnosis, whereas it reached a plateau in bone sarcoma patients at 3 years. Median PBMS was 1.67 months. Univariate factors associated with better PBMS included ASPS histology, initial surgical treatment, and brain irradiation for non-surgically treated patients. Conclusion Our study revealed a discrepancy in the timing of occurrence of brain metastasis between STS and bone sarcoma. However, patients with brain metastasis had a poor prognosis, implicating the brain as the last fortress of sarcoma. J. Surg. Oncol. 2011; 104:765-770. © 2011 Wiley Periodicals, Inc.

Original languageEnglish
Pages (from-to)765-770
Number of pages6
JournalJournal of Surgical Oncology
Volume104
Issue number7
DOIs
Publication statusPublished - Dec 1 2011
Externally publishedYes

Fingerprint

Sarcoma
Neoplasm Metastasis
Bone and Bones
Brain
Alveolar Soft Part Sarcoma
Survival
Incidence
Osteosarcoma
Histology

Keywords

  • alveolar soft part sarcoma
  • brain metastasis
  • osteosarcoma
  • soft tissue sarcoma

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Brain, the last fortress of sarcoma : Similar dismal outcome but discrepancy of timing of brain metastasis in bone and soft tissue sarcoma. / Chou, Yi Sheng; Liu, Chun Yu; Chen, Wei Ming; Chen, Tain Hsiung; Chen, Paul Chih Hsueh; Wu, Hung Ta Hondar; Shiau, Cheng Ying; Wu, Yu Chung; Liu, Chien Lin; Chao, Ta Chung; Tzeng, Cheng Hwai; Wong, Tai-Tong; Yen, Chueh Chuan.

In: Journal of Surgical Oncology, Vol. 104, No. 7, 01.12.2011, p. 765-770.

Research output: Contribution to journalArticle

Chou, YS, Liu, CY, Chen, WM, Chen, TH, Chen, PCH, Wu, HTH, Shiau, CY, Wu, YC, Liu, CL, Chao, TC, Tzeng, CH, Wong, T-T & Yen, CC 2011, 'Brain, the last fortress of sarcoma: Similar dismal outcome but discrepancy of timing of brain metastasis in bone and soft tissue sarcoma', Journal of Surgical Oncology, vol. 104, no. 7, pp. 765-770. https://doi.org/10.1002/jso.22011
Chou, Yi Sheng ; Liu, Chun Yu ; Chen, Wei Ming ; Chen, Tain Hsiung ; Chen, Paul Chih Hsueh ; Wu, Hung Ta Hondar ; Shiau, Cheng Ying ; Wu, Yu Chung ; Liu, Chien Lin ; Chao, Ta Chung ; Tzeng, Cheng Hwai ; Wong, Tai-Tong ; Yen, Chueh Chuan. / Brain, the last fortress of sarcoma : Similar dismal outcome but discrepancy of timing of brain metastasis in bone and soft tissue sarcoma. In: Journal of Surgical Oncology. 2011 ; Vol. 104, No. 7. pp. 765-770.
@article{3b00a2de5c554412bef978e39f84c312,
title = "Brain, the last fortress of sarcoma: Similar dismal outcome but discrepancy of timing of brain metastasis in bone and soft tissue sarcoma",
abstract = "Background and Objective Brain metastasis is a rare but dismal event in sarcomas. However, the pattern of occurrence and the prognostic factors associated with post-brain metastasis survival (PBMS) are not yet well-characterized. Methods Sarcoma patients treated at one institute within 10-year period were retrospectively reviewed and those with brain metastasis were identified. The incidence of brain metastasis was demonstrated by case per person-years and cumulative incidence curves. Univariate factors associated with PBMS were analyzed. Results Among 611 sarcoma patients, 20 (3.3{\%}) developed brain metastasis. Alveolar soft part sarcoma (ASPS) and osteosarcoma were the most common subtypes. Overall, the cumulative incidence was 3.9{\%} at 5 years and 8.4{\%} at 10 years. However, the incidence in STS patients continued to rise up to 10 years after primary diagnosis, whereas it reached a plateau in bone sarcoma patients at 3 years. Median PBMS was 1.67 months. Univariate factors associated with better PBMS included ASPS histology, initial surgical treatment, and brain irradiation for non-surgically treated patients. Conclusion Our study revealed a discrepancy in the timing of occurrence of brain metastasis between STS and bone sarcoma. However, patients with brain metastasis had a poor prognosis, implicating the brain as the last fortress of sarcoma. J. Surg. Oncol. 2011; 104:765-770. {\circledC} 2011 Wiley Periodicals, Inc.",
keywords = "alveolar soft part sarcoma, brain metastasis, osteosarcoma, soft tissue sarcoma",
author = "Chou, {Yi Sheng} and Liu, {Chun Yu} and Chen, {Wei Ming} and Chen, {Tain Hsiung} and Chen, {Paul Chih Hsueh} and Wu, {Hung Ta Hondar} and Shiau, {Cheng Ying} and Wu, {Yu Chung} and Liu, {Chien Lin} and Chao, {Ta Chung} and Tzeng, {Cheng Hwai} and Tai-Tong Wong and Yen, {Chueh Chuan}",
year = "2011",
month = "12",
day = "1",
doi = "10.1002/jso.22011",
language = "English",
volume = "104",
pages = "765--770",
journal = "Journal of Surgical Oncology",
issn = "0022-4790",
publisher = "Wiley-Liss Inc.",
number = "7",

}

TY - JOUR

T1 - Brain, the last fortress of sarcoma

T2 - Similar dismal outcome but discrepancy of timing of brain metastasis in bone and soft tissue sarcoma

AU - Chou, Yi Sheng

AU - Liu, Chun Yu

AU - Chen, Wei Ming

AU - Chen, Tain Hsiung

AU - Chen, Paul Chih Hsueh

AU - Wu, Hung Ta Hondar

AU - Shiau, Cheng Ying

AU - Wu, Yu Chung

AU - Liu, Chien Lin

AU - Chao, Ta Chung

AU - Tzeng, Cheng Hwai

AU - Wong, Tai-Tong

AU - Yen, Chueh Chuan

PY - 2011/12/1

Y1 - 2011/12/1

N2 - Background and Objective Brain metastasis is a rare but dismal event in sarcomas. However, the pattern of occurrence and the prognostic factors associated with post-brain metastasis survival (PBMS) are not yet well-characterized. Methods Sarcoma patients treated at one institute within 10-year period were retrospectively reviewed and those with brain metastasis were identified. The incidence of brain metastasis was demonstrated by case per person-years and cumulative incidence curves. Univariate factors associated with PBMS were analyzed. Results Among 611 sarcoma patients, 20 (3.3%) developed brain metastasis. Alveolar soft part sarcoma (ASPS) and osteosarcoma were the most common subtypes. Overall, the cumulative incidence was 3.9% at 5 years and 8.4% at 10 years. However, the incidence in STS patients continued to rise up to 10 years after primary diagnosis, whereas it reached a plateau in bone sarcoma patients at 3 years. Median PBMS was 1.67 months. Univariate factors associated with better PBMS included ASPS histology, initial surgical treatment, and brain irradiation for non-surgically treated patients. Conclusion Our study revealed a discrepancy in the timing of occurrence of brain metastasis between STS and bone sarcoma. However, patients with brain metastasis had a poor prognosis, implicating the brain as the last fortress of sarcoma. J. Surg. Oncol. 2011; 104:765-770. © 2011 Wiley Periodicals, Inc.

AB - Background and Objective Brain metastasis is a rare but dismal event in sarcomas. However, the pattern of occurrence and the prognostic factors associated with post-brain metastasis survival (PBMS) are not yet well-characterized. Methods Sarcoma patients treated at one institute within 10-year period were retrospectively reviewed and those with brain metastasis were identified. The incidence of brain metastasis was demonstrated by case per person-years and cumulative incidence curves. Univariate factors associated with PBMS were analyzed. Results Among 611 sarcoma patients, 20 (3.3%) developed brain metastasis. Alveolar soft part sarcoma (ASPS) and osteosarcoma were the most common subtypes. Overall, the cumulative incidence was 3.9% at 5 years and 8.4% at 10 years. However, the incidence in STS patients continued to rise up to 10 years after primary diagnosis, whereas it reached a plateau in bone sarcoma patients at 3 years. Median PBMS was 1.67 months. Univariate factors associated with better PBMS included ASPS histology, initial surgical treatment, and brain irradiation for non-surgically treated patients. Conclusion Our study revealed a discrepancy in the timing of occurrence of brain metastasis between STS and bone sarcoma. However, patients with brain metastasis had a poor prognosis, implicating the brain as the last fortress of sarcoma. J. Surg. Oncol. 2011; 104:765-770. © 2011 Wiley Periodicals, Inc.

KW - alveolar soft part sarcoma

KW - brain metastasis

KW - osteosarcoma

KW - soft tissue sarcoma

UR - http://www.scopus.com/inward/record.url?scp=80255132751&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80255132751&partnerID=8YFLogxK

U2 - 10.1002/jso.22011

DO - 10.1002/jso.22011

M3 - Article

VL - 104

SP - 765

EP - 770

JO - Journal of Surgical Oncology

JF - Journal of Surgical Oncology

SN - 0022-4790

IS - 7

ER -