Brain stimulation improves cognitive control by modulating medial-frontal activity and preSMA-vmPFC functional connectivity

Jiaxin Yu, Philip Tseng, Daisy L. Hung, Shih Wei Wu, Chi Hung Juan

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Previous research has demonstrated that brain stimulation can improve inhibitory control. However, the neural mechanisms underlying such artificially induced improvement remain unclear. In this study, by coupling anodal transcranial direct current stimulation (atDCS) with functional MRI, we found that atDCS over preSMA effectively improved stopping speed, which was associated with increased BOLD response in the preSMA and ventromedial prefrontal cortex (vmPFC). Furthermore, such atDCS-induced BOLD increase in vmPFC was positively correlated with participants' improvement in stopping efficiency, and the functional connectivity between preSMA and vmPFC increased during successful stop. These results suggest that the rapid behavioral improvement from preSMA brain stimulation involves modulated medial-frontal activity and preSMA-vmPFC functional connectivity.

Original languageEnglish
Pages (from-to)4004-4015
Number of pages12
JournalHuman Brain Mapping
Volume36
Issue number10
DOIs
Publication statusPublished - Oct 1 2015

Keywords

  • FMRI
  • PreSMA
  • Response inhibition
  • TDCS
  • VmPFC

ASJC Scopus subject areas

  • Clinical Neurology
  • Anatomy
  • Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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