Brachial-ankle pulse wave velocity as an early indicator of left ventricular diastolic function among hypertensive subjects

Chao Ping Wang, Wei Chin Hung, Teng Hung Yu, Hui-Ling Hsu, Yen Hsun Chen, Cheng An Chiu, Li Fen Lu, Fu Mei Chung, Ya Ai Cheng, Yau Jiunn Lee

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

While increased arterial stiffness is a known risk of cardiovascular disease, pulse wave velocity (PWV) is a conventionally adopted index of arterial stiffness. However, the relationship between PWV and left ventricular functions are not thoroughly evaluated. This cross-sectional study investigated whether PWV measurement is an early indicator of left ventricular (LV) dysfunction. A noninvasive, volume-plethysmographic apparatus was used to determine blood pressure, electrocardiogram, heart sounds, and PWV in 42 consecutively diagnosed subjects with hypertension, and 42 sex- and age-matched nonhypertension subjects were studied. Arterial stiffness and aortic stiffness were evaluated by brachial-ankle (b-a) PWV, heart-carotid (h-c) PWV, heart-femoral (h-f) PWV, carotid-femoral (c-f) PWV, and femoral-ankle (f-a) PWV. Function of LV was estimated by tissue Doppler imaging (TDI) echocardiography. Hypertension subjects exhibited higher b-a PWV and late diastolic mitral flow velocity values than those of nonhypertensive subjects. Pearson correlation analysis revealed that LV diastolic function (Emav) negatively correlated with c-f PWV and b-a PWV. Multiple linear regression analysis indicated that b-a PWV was independently and negatively associated with LV diastolic function (Emav). Further analysis by stratified hypertensive status, the b-a PWV were independently and negatively associated with Emav in hypertensive subjects (p = 0.004) only. In conclusion, the b-a PWV, but not c-f PWV, h-c PWV, h-f PWV, or f-a PWV, is significantly correlated with LV diastolic function in hypertensive subjects, indicating that b-a PWV involving both central and peripheral components of arterial stiffness may be an early indicator of LV dysfunction.

Original languageEnglish
Pages (from-to)31-43
Number of pages13
JournalClinical and Experimental Hypertension
Volume31
Issue number1
DOIs
Publication statusPublished - Feb 1 2009
Externally publishedYes

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Pulse Wave Analysis
Left Ventricular Function
Ankle
Arm
Thigh
Vascular Stiffness
Left Ventricular Dysfunction
Hypertension
Heart Sounds

Keywords

  • Arterial stiffness
  • Brachial-ankle pulse wave velocity
  • Hypertension
  • LV diastolic function
  • Tissue Doppler imaging

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology

Cite this

Brachial-ankle pulse wave velocity as an early indicator of left ventricular diastolic function among hypertensive subjects. / Wang, Chao Ping; Hung, Wei Chin; Yu, Teng Hung; Hsu, Hui-Ling; Chen, Yen Hsun; Chiu, Cheng An; Lu, Li Fen; Chung, Fu Mei; Cheng, Ya Ai; Lee, Yau Jiunn.

In: Clinical and Experimental Hypertension, Vol. 31, No. 1, 01.02.2009, p. 31-43.

Research output: Contribution to journalArticle

Wang, Chao Ping ; Hung, Wei Chin ; Yu, Teng Hung ; Hsu, Hui-Ling ; Chen, Yen Hsun ; Chiu, Cheng An ; Lu, Li Fen ; Chung, Fu Mei ; Cheng, Ya Ai ; Lee, Yau Jiunn. / Brachial-ankle pulse wave velocity as an early indicator of left ventricular diastolic function among hypertensive subjects. In: Clinical and Experimental Hypertension. 2009 ; Vol. 31, No. 1. pp. 31-43.
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