Brachial-ankle pulse wave velocity as an early indicator of left ventricular diastolic function among hypertensive subjects

Chao Ping Wang, Wei Chin Hung, Teng Hung Yu, Hui-Ling Hsu, Yen Hsun Chen, Cheng An Chiu, Li Fen Lu, Fu Mei Chung, Ya Ai Cheng, Yau Jiunn Lee

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

While increased arterial stiffness is a known risk of cardiovascular disease, pulse wave velocity (PWV) is a conventionally adopted index of arterial stiffness. However, the relationship between PWV and left ventricular functions are not thoroughly evaluated. This cross-sectional study investigated whether PWV measurement is an early indicator of left ventricular (LV) dysfunction. A noninvasive, volume-plethysmographic apparatus was used to determine blood pressure, electrocardiogram, heart sounds, and PWV in 42 consecutively diagnosed subjects with hypertension, and 42 sex- and age-matched nonhypertension subjects were studied. Arterial stiffness and aortic stiffness were evaluated by brachial-ankle (b-a) PWV, heart-carotid (h-c) PWV, heart-femoral (h-f) PWV, carotid-femoral (c-f) PWV, and femoral-ankle (f-a) PWV. Function of LV was estimated by tissue Doppler imaging (TDI) echocardiography. Hypertension subjects exhibited higher b-a PWV and late diastolic mitral flow velocity values than those of nonhypertensive subjects. Pearson correlation analysis revealed that LV diastolic function (Emav) negatively correlated with c-f PWV and b-a PWV. Multiple linear regression analysis indicated that b-a PWV was independently and negatively associated with LV diastolic function (Emav). Further analysis by stratified hypertensive status, the b-a PWV were independently and negatively associated with Emav in hypertensive subjects (p = 0.004) only. In conclusion, the b-a PWV, but not c-f PWV, h-c PWV, h-f PWV, or f-a PWV, is significantly correlated with LV diastolic function in hypertensive subjects, indicating that b-a PWV involving both central and peripheral components of arterial stiffness may be an early indicator of LV dysfunction.

Original languageEnglish
Pages (from-to)31-43
Number of pages13
JournalClinical and Experimental Hypertension
Volume31
Issue number1
DOIs
Publication statusPublished - Feb 1 2009
Externally publishedYes

Keywords

  • Arterial stiffness
  • Brachial-ankle pulse wave velocity
  • Hypertension
  • LV diastolic function
  • Tissue Doppler imaging

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology

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  • Cite this

    Wang, C. P., Hung, W. C., Yu, T. H., Hsu, H-L., Chen, Y. H., Chiu, C. A., Lu, L. F., Chung, F. M., Cheng, Y. A., & Lee, Y. J. (2009). Brachial-ankle pulse wave velocity as an early indicator of left ventricular diastolic function among hypertensive subjects. Clinical and Experimental Hypertension, 31(1), 31-43. https://doi.org/10.1080/10641960802409796