Abstract
While increased arterial stiffness is a known risk of cardiovascular disease, pulse wave velocity (PWV) is a conventionally adopted index of arterial stiffness. However, the relationship between PWV and left ventricular functions are not thoroughly evaluated. This cross-sectional study investigated whether PWV measurement is an early indicator of left ventricular (LV) dysfunction. A noninvasive, volume-plethysmographic apparatus was used to determine blood pressure, electrocardiogram, heart sounds, and PWV in 42 consecutively diagnosed subjects with hypertension, and 42 sex- and age-matched nonhypertension subjects were studied. Arterial stiffness and aortic stiffness were evaluated by brachial-ankle (b-a) PWV, heart-carotid (h-c) PWV, heart-femoral (h-f) PWV, carotid-femoral (c-f) PWV, and femoral-ankle (f-a) PWV. Function of LV was estimated by tissue Doppler imaging (TDI) echocardiography. Hypertension subjects exhibited higher b-a PWV and late diastolic mitral flow velocity values than those of nonhypertensive subjects. Pearson correlation analysis revealed that LV diastolic function (Emav) negatively correlated with c-f PWV and b-a PWV. Multiple linear regression analysis indicated that b-a PWV was independently and negatively associated with LV diastolic function (Emav). Further analysis by stratified hypertensive status, the b-a PWV were independently and negatively associated with Emav in hypertensive subjects (p = 0.004) only. In conclusion, the b-a PWV, but not c-f PWV, h-c PWV, h-f PWV, or f-a PWV, is significantly correlated with LV diastolic function in hypertensive subjects, indicating that b-a PWV involving both central and peripheral components of arterial stiffness may be an early indicator of LV dysfunction.
| Original language | English |
|---|---|
| Pages (from-to) | 31-43 |
| Number of pages | 13 |
| Journal | Clinical and Experimental Hypertension |
| Volume | 31 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Feb 1 2009 |
| Externally published | Yes |
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Keywords
- Arterial stiffness
- Brachial-ankle pulse wave velocity
- Hypertension
- LV diastolic function
- Tissue Doppler imaging
ASJC Scopus subject areas
- Internal Medicine
- Physiology
Cite this
Brachial-ankle pulse wave velocity as an early indicator of left ventricular diastolic function among hypertensive subjects. / Wang, Chao Ping; Hung, Wei Chin; Yu, Teng Hung; Hsu, Hui-Ling; Chen, Yen Hsun; Chiu, Cheng An; Lu, Li Fen; Chung, Fu Mei; Cheng, Ya Ai; Lee, Yau Jiunn.
In: Clinical and Experimental Hypertension, Vol. 31, No. 1, 01.02.2009, p. 31-43.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Brachial-ankle pulse wave velocity as an early indicator of left ventricular diastolic function among hypertensive subjects
AU - Wang, Chao Ping
AU - Hung, Wei Chin
AU - Yu, Teng Hung
AU - Hsu, Hui-Ling
AU - Chen, Yen Hsun
AU - Chiu, Cheng An
AU - Lu, Li Fen
AU - Chung, Fu Mei
AU - Cheng, Ya Ai
AU - Lee, Yau Jiunn
PY - 2009/2/1
Y1 - 2009/2/1
N2 - While increased arterial stiffness is a known risk of cardiovascular disease, pulse wave velocity (PWV) is a conventionally adopted index of arterial stiffness. However, the relationship between PWV and left ventricular functions are not thoroughly evaluated. This cross-sectional study investigated whether PWV measurement is an early indicator of left ventricular (LV) dysfunction. A noninvasive, volume-plethysmographic apparatus was used to determine blood pressure, electrocardiogram, heart sounds, and PWV in 42 consecutively diagnosed subjects with hypertension, and 42 sex- and age-matched nonhypertension subjects were studied. Arterial stiffness and aortic stiffness were evaluated by brachial-ankle (b-a) PWV, heart-carotid (h-c) PWV, heart-femoral (h-f) PWV, carotid-femoral (c-f) PWV, and femoral-ankle (f-a) PWV. Function of LV was estimated by tissue Doppler imaging (TDI) echocardiography. Hypertension subjects exhibited higher b-a PWV and late diastolic mitral flow velocity values than those of nonhypertensive subjects. Pearson correlation analysis revealed that LV diastolic function (Emav) negatively correlated with c-f PWV and b-a PWV. Multiple linear regression analysis indicated that b-a PWV was independently and negatively associated with LV diastolic function (Emav). Further analysis by stratified hypertensive status, the b-a PWV were independently and negatively associated with Emav in hypertensive subjects (p = 0.004) only. In conclusion, the b-a PWV, but not c-f PWV, h-c PWV, h-f PWV, or f-a PWV, is significantly correlated with LV diastolic function in hypertensive subjects, indicating that b-a PWV involving both central and peripheral components of arterial stiffness may be an early indicator of LV dysfunction.
AB - While increased arterial stiffness is a known risk of cardiovascular disease, pulse wave velocity (PWV) is a conventionally adopted index of arterial stiffness. However, the relationship between PWV and left ventricular functions are not thoroughly evaluated. This cross-sectional study investigated whether PWV measurement is an early indicator of left ventricular (LV) dysfunction. A noninvasive, volume-plethysmographic apparatus was used to determine blood pressure, electrocardiogram, heart sounds, and PWV in 42 consecutively diagnosed subjects with hypertension, and 42 sex- and age-matched nonhypertension subjects were studied. Arterial stiffness and aortic stiffness were evaluated by brachial-ankle (b-a) PWV, heart-carotid (h-c) PWV, heart-femoral (h-f) PWV, carotid-femoral (c-f) PWV, and femoral-ankle (f-a) PWV. Function of LV was estimated by tissue Doppler imaging (TDI) echocardiography. Hypertension subjects exhibited higher b-a PWV and late diastolic mitral flow velocity values than those of nonhypertensive subjects. Pearson correlation analysis revealed that LV diastolic function (Emav) negatively correlated with c-f PWV and b-a PWV. Multiple linear regression analysis indicated that b-a PWV was independently and negatively associated with LV diastolic function (Emav). Further analysis by stratified hypertensive status, the b-a PWV were independently and negatively associated with Emav in hypertensive subjects (p = 0.004) only. In conclusion, the b-a PWV, but not c-f PWV, h-c PWV, h-f PWV, or f-a PWV, is significantly correlated with LV diastolic function in hypertensive subjects, indicating that b-a PWV involving both central and peripheral components of arterial stiffness may be an early indicator of LV dysfunction.
KW - Arterial stiffness
KW - Brachial-ankle pulse wave velocity
KW - Hypertension
KW - LV diastolic function
KW - Tissue Doppler imaging
UR - http://www.scopus.com/inward/record.url?scp=60549087174&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=60549087174&partnerID=8YFLogxK
U2 - 10.1080/10641960802409796
DO - 10.1080/10641960802409796
M3 - Article
VL - 31
SP - 31
EP - 43
JO - Clinical and Experimental Hypertension
JF - Clinical and Experimental Hypertension
SN - 1064-1963
IS - 1
ER -