Abstract
Objective: To present male gender preselection after successive gestational hyperandrogenism and female pseudohermaphroditism by pregnancy luteomas. Design: Case report. Setting: University-based teaching hospital. Patient(s): We describe herein a gravida who presented two successive 46, XX disorders of sex development with apparent female genitalia with an enlarged clitoris due to maternal androgen excess from pregnancy luteoma. The maternal hyperandrogenemia returned to a normal level and bilateral luteoma regressed spontaneously postpartum. After gender preselection by Y-bearing spermatozoa for intrauterine insemination at the third gestation, a healthy boy was born in spite of the exaggerated maternal androgen production of pregnancy luteoma to avoid 46, XX disorders of sex development. Intervention(s): Y-bearing spermatozoa for intrauterine insemination as male gender preselection. Main Outcome Measure(s): Boy born after gender preselection for intrauterine insemination and cesarean section. Result(s): Healthy boy born without disorder of sex development after antenatal maternal androgen excess of ovarian luteoma. Conclusion(s): Successive pregnancy luteomas associated with maternal hyperandrogenism may cause female disorders of sex development. Male preselection ameliorates the insult of external genitalia ambiguity by antenatal androgen excess in this matter of concern.
| Original language | English |
|---|---|
| Journal | Fertility and Sterility |
| Volume | 91 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jun 2009 |
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Keywords
- disorders of sex development (DSD)
- Pregnancy luteomas
ASJC Scopus subject areas
- Obstetrics and Gynaecology
- Reproductive Medicine
Cite this
Boy born after gender preselection following successive gestational androgen excess of maternal luteoma and female disorders of sex development. / Chen, Chi Huang; Chen, I. Ching; Wang, Yu Chi; Liu, Jah Yao; Wu, Gwo Jang; Tzeng, Chii Ruey.
In: Fertility and Sterility, Vol. 91, No. 6, 06.2009.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Boy born after gender preselection following successive gestational androgen excess of maternal luteoma and female disorders of sex development
AU - Chen, Chi Huang
AU - Chen, I. Ching
AU - Wang, Yu Chi
AU - Liu, Jah Yao
AU - Wu, Gwo Jang
AU - Tzeng, Chii Ruey
PY - 2009/6
Y1 - 2009/6
N2 - Objective: To present male gender preselection after successive gestational hyperandrogenism and female pseudohermaphroditism by pregnancy luteomas. Design: Case report. Setting: University-based teaching hospital. Patient(s): We describe herein a gravida who presented two successive 46, XX disorders of sex development with apparent female genitalia with an enlarged clitoris due to maternal androgen excess from pregnancy luteoma. The maternal hyperandrogenemia returned to a normal level and bilateral luteoma regressed spontaneously postpartum. After gender preselection by Y-bearing spermatozoa for intrauterine insemination at the third gestation, a healthy boy was born in spite of the exaggerated maternal androgen production of pregnancy luteoma to avoid 46, XX disorders of sex development. Intervention(s): Y-bearing spermatozoa for intrauterine insemination as male gender preselection. Main Outcome Measure(s): Boy born after gender preselection for intrauterine insemination and cesarean section. Result(s): Healthy boy born without disorder of sex development after antenatal maternal androgen excess of ovarian luteoma. Conclusion(s): Successive pregnancy luteomas associated with maternal hyperandrogenism may cause female disorders of sex development. Male preselection ameliorates the insult of external genitalia ambiguity by antenatal androgen excess in this matter of concern.
AB - Objective: To present male gender preselection after successive gestational hyperandrogenism and female pseudohermaphroditism by pregnancy luteomas. Design: Case report. Setting: University-based teaching hospital. Patient(s): We describe herein a gravida who presented two successive 46, XX disorders of sex development with apparent female genitalia with an enlarged clitoris due to maternal androgen excess from pregnancy luteoma. The maternal hyperandrogenemia returned to a normal level and bilateral luteoma regressed spontaneously postpartum. After gender preselection by Y-bearing spermatozoa for intrauterine insemination at the third gestation, a healthy boy was born in spite of the exaggerated maternal androgen production of pregnancy luteoma to avoid 46, XX disorders of sex development. Intervention(s): Y-bearing spermatozoa for intrauterine insemination as male gender preselection. Main Outcome Measure(s): Boy born after gender preselection for intrauterine insemination and cesarean section. Result(s): Healthy boy born without disorder of sex development after antenatal maternal androgen excess of ovarian luteoma. Conclusion(s): Successive pregnancy luteomas associated with maternal hyperandrogenism may cause female disorders of sex development. Male preselection ameliorates the insult of external genitalia ambiguity by antenatal androgen excess in this matter of concern.
KW - disorders of sex development (DSD)
KW - Pregnancy luteomas
UR - http://www.scopus.com/inward/record.url?scp=67349281715&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67349281715&partnerID=8YFLogxK
U2 - 10.1016/j.fertnstert.2008.10.074
DO - 10.1016/j.fertnstert.2008.10.074
M3 - Article
C2 - 19110243
AN - SCOPUS:67349281715
VL - 91
JO - Fertility and Sterility
JF - Fertility and Sterility
SN - 0015-0282
IS - 6
ER -