Botulinum toxin to improve results in cleft lip repair

A double-blinded, randomized, vehicle-controlled clinical trial

Chun Shin Chang, Christopher Glenn Wallace, Yen Chang Hsiao, Chee Jen Chang, Philip Kuo Ting Chen

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Background: Most patients with facial scarring would value even a slight improvement in scar quality. Botulinum toxin A is widely used to alleviate facial dynamic rhytides but is also believed to improve scar quality by reducing wound tension during healing. The main objective was to assess the effect of Botulinum toxin on scars resultant from standardized upper lip wounds. Methods: In this double-blinded, randomized, vehicle-controlled, prospective clinical trial, 60 consecutive consenting adults undergoing cleft lip scar revision (CLSR) surgery between July 2010 and March 2012 were randomized to receive botulinum toxin A (n=30) or vehicle (normal saline; n=30) injections into the subjacent orbicularis oris muscle immediately after wound closure. Scars were independently assessed at 6-months follow-up in blinded fashion using: Vancouver Scar Scale (VSS), Visual Analogue Scale (VAS) and photographic plus ultrasound measurements of scar widths. Results: 58 patients completed the trial. All scar assessment modalities revealed statistically significantly better scars in the experimental than the vehicle-control group. Conclusion: Quality of surgical upper lip scars, which are oriented perpendicular to the direction of pull of the underlying orbicularis oris muscle, is significantly improved by its temporary paralysis during wound healing. Trial Registration: ClinicalTrials.gov NCT01429402.

Original languageEnglish
Article numbere115690
JournalPLoS One
Volume9
Issue number12
DOIs
Publication statusPublished - Dec 26 2014
Externally publishedYes

Fingerprint

botulinum toxin
Botulinum Toxins
Cleft Lip
lips
animal injuries
Cicatrix
clinical trials
Type A Botulinum Toxins
Repair
Randomized Controlled Trials
Muscle
muscles
paralysis
tissue repair
prospective studies
Surgery
surgery
Ultrasonics
injection
Lip

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Botulinum toxin to improve results in cleft lip repair : A double-blinded, randomized, vehicle-controlled clinical trial. / Chang, Chun Shin; Wallace, Christopher Glenn; Hsiao, Yen Chang; Chang, Chee Jen; Chen, Philip Kuo Ting.

In: PLoS One, Vol. 9, No. 12, e115690, 26.12.2014.

Research output: Contribution to journalArticle

Chang, Chun Shin ; Wallace, Christopher Glenn ; Hsiao, Yen Chang ; Chang, Chee Jen ; Chen, Philip Kuo Ting. / Botulinum toxin to improve results in cleft lip repair : A double-blinded, randomized, vehicle-controlled clinical trial. In: PLoS One. 2014 ; Vol. 9, No. 12.
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