Boron-rich, cytocompatible block copolymer nanoparticles by polymerization-induced self-assembly

Lin Chiang Sherlock Huang, Dao Le, I. Lun Hsiao, Susanne Fritsch-Decker, Christian Hald, Su Ching Huang, Jen Kun Chen, Jih Ru Hwu, Carsten Weiss, Min Hua Hsu, Guillaume Delaittre

Research output: Contribution to journalArticlepeer-review

Abstract

Core-shell nanoparticles (NPs) with a boron-rich core were synthesized by RAFT-mediated polymerization-induced self-assembly using a new methacrylic boronate ester monomer. Under specific conditions, sub-100 nm spherical NPs could be obtained at high conversions by either emulsion or dispersion RAFT polymerization using poly(oligo(ethylene glycol) methacrylate) (POEGMA) dithiobenozate-based chain transfer agents. Phenylboronic acid surface-functionalized NPs were obtained using a telechelic POEGMA. Primary data on biocompatibility is provided and suggests suitability as boron delivery agent for boron neutron capture therapy. This journal is

Original languageEnglish
Pages (from-to)50-56
Number of pages7
JournalPolymer Chemistry
Volume12
Issue number1
DOIs
Publication statusPublished - Jan 7 2021

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Polymers and Plastics
  • Organic Chemistry

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