Boron neutron capture therapy for glioblastoma multiforme

Enhanced drug delivery and antitumor effect following blood-brain barrier disruption induced by focused ultrasound

Feng Yi Yang, Yi Wei Chen, Fong In Chou, Sang Hue Yen, Yi Li Lin, Tai-Tong Wong

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Aim: This study investigated whether the efficacy of boron neutron capture therapy was enhanced by means of intravenous administration of boronophenylalanine (BPA) with blood-brain barrier disruption induced by focused ultrasound (FUS). Materials & methods: BPA was administered, followed by pulsed FUS, and the boron concentration in the treated brains was quantified by inductively coupled plasma mass spectroscopy. Growth of the firefly luciferase-labeled glioma cells was monitored through noninvasive biophotonic imaging. Finally, the brain tissue was histologically examined after sacrifice. Results: Compared with the nonsonicated tumor group, animals treated with an injection of 500 mg/kg of BPA followed by FUS exhibited not only significantly increased accumulation of the drug at the sonicated tumor site, but also a significantly elevated tumor-to-normal brain drug ratio (p < 0.05). Discussion: The data demonstrated that FUS significantly enhances the tumor-to-normal brain drug ratio in the sonicated tumor and subsequently the efficacy of boron neutron capture therapy.

Original languageEnglish
Pages (from-to)1361-1369
Number of pages9
JournalFuture Oncology
Volume8
Issue number10
DOIs
Publication statusPublished - Oct 1 2012
Externally publishedYes

Fingerprint

Boron Neutron Capture Therapy
Glioblastoma
Blood-Brain Barrier
Antineoplastic Agents
Brain
Neoplasms
Pharmaceutical Preparations
Firefly Luciferases
Boron
Glioma
Intravenous Administration
Mass Spectrometry
Injections
Growth

Keywords

  • blood-brain barrier disruption
  • boron neutron capture therapy
  • boronophenylalanine
  • brain tumor
  • focused ultrasound

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Boron neutron capture therapy for glioblastoma multiforme : Enhanced drug delivery and antitumor effect following blood-brain barrier disruption induced by focused ultrasound. / Yang, Feng Yi; Chen, Yi Wei; Chou, Fong In; Yen, Sang Hue; Lin, Yi Li; Wong, Tai-Tong.

In: Future Oncology, Vol. 8, No. 10, 01.10.2012, p. 1361-1369.

Research output: Contribution to journalArticle

@article{75dfa4a99b0f44bdad28960eb9ecfc95,
title = "Boron neutron capture therapy for glioblastoma multiforme: Enhanced drug delivery and antitumor effect following blood-brain barrier disruption induced by focused ultrasound",
abstract = "Aim: This study investigated whether the efficacy of boron neutron capture therapy was enhanced by means of intravenous administration of boronophenylalanine (BPA) with blood-brain barrier disruption induced by focused ultrasound (FUS). Materials & methods: BPA was administered, followed by pulsed FUS, and the boron concentration in the treated brains was quantified by inductively coupled plasma mass spectroscopy. Growth of the firefly luciferase-labeled glioma cells was monitored through noninvasive biophotonic imaging. Finally, the brain tissue was histologically examined after sacrifice. Results: Compared with the nonsonicated tumor group, animals treated with an injection of 500 mg/kg of BPA followed by FUS exhibited not only significantly increased accumulation of the drug at the sonicated tumor site, but also a significantly elevated tumor-to-normal brain drug ratio (p < 0.05). Discussion: The data demonstrated that FUS significantly enhances the tumor-to-normal brain drug ratio in the sonicated tumor and subsequently the efficacy of boron neutron capture therapy.",
keywords = "blood-brain barrier disruption, boron neutron capture therapy, boronophenylalanine, brain tumor, focused ultrasound",
author = "Yang, {Feng Yi} and Chen, {Yi Wei} and Chou, {Fong In} and Yen, {Sang Hue} and Lin, {Yi Li} and Tai-Tong Wong",
year = "2012",
month = "10",
day = "1",
doi = "10.2217/fon.12.118",
language = "English",
volume = "8",
pages = "1361--1369",
journal = "Future Oncology",
issn = "1479-6694",
publisher = "Future Medicine Ltd.",
number = "10",

}

TY - JOUR

T1 - Boron neutron capture therapy for glioblastoma multiforme

T2 - Enhanced drug delivery and antitumor effect following blood-brain barrier disruption induced by focused ultrasound

AU - Yang, Feng Yi

AU - Chen, Yi Wei

AU - Chou, Fong In

AU - Yen, Sang Hue

AU - Lin, Yi Li

AU - Wong, Tai-Tong

PY - 2012/10/1

Y1 - 2012/10/1

N2 - Aim: This study investigated whether the efficacy of boron neutron capture therapy was enhanced by means of intravenous administration of boronophenylalanine (BPA) with blood-brain barrier disruption induced by focused ultrasound (FUS). Materials & methods: BPA was administered, followed by pulsed FUS, and the boron concentration in the treated brains was quantified by inductively coupled plasma mass spectroscopy. Growth of the firefly luciferase-labeled glioma cells was monitored through noninvasive biophotonic imaging. Finally, the brain tissue was histologically examined after sacrifice. Results: Compared with the nonsonicated tumor group, animals treated with an injection of 500 mg/kg of BPA followed by FUS exhibited not only significantly increased accumulation of the drug at the sonicated tumor site, but also a significantly elevated tumor-to-normal brain drug ratio (p < 0.05). Discussion: The data demonstrated that FUS significantly enhances the tumor-to-normal brain drug ratio in the sonicated tumor and subsequently the efficacy of boron neutron capture therapy.

AB - Aim: This study investigated whether the efficacy of boron neutron capture therapy was enhanced by means of intravenous administration of boronophenylalanine (BPA) with blood-brain barrier disruption induced by focused ultrasound (FUS). Materials & methods: BPA was administered, followed by pulsed FUS, and the boron concentration in the treated brains was quantified by inductively coupled plasma mass spectroscopy. Growth of the firefly luciferase-labeled glioma cells was monitored through noninvasive biophotonic imaging. Finally, the brain tissue was histologically examined after sacrifice. Results: Compared with the nonsonicated tumor group, animals treated with an injection of 500 mg/kg of BPA followed by FUS exhibited not only significantly increased accumulation of the drug at the sonicated tumor site, but also a significantly elevated tumor-to-normal brain drug ratio (p < 0.05). Discussion: The data demonstrated that FUS significantly enhances the tumor-to-normal brain drug ratio in the sonicated tumor and subsequently the efficacy of boron neutron capture therapy.

KW - blood-brain barrier disruption

KW - boron neutron capture therapy

KW - boronophenylalanine

KW - brain tumor

KW - focused ultrasound

UR - http://www.scopus.com/inward/record.url?scp=84868586326&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84868586326&partnerID=8YFLogxK

U2 - 10.2217/fon.12.118

DO - 10.2217/fon.12.118

M3 - Article

VL - 8

SP - 1361

EP - 1369

JO - Future Oncology

JF - Future Oncology

SN - 1479-6694

IS - 10

ER -