Bone marrow transplantation from HL-A-matched donors to patients with acute leukemia: Toxicity and antileukemic effect

R. G. Gbaw, R. A. Yankee, G. N. Rogentine, B. G. Leventhal, G. P. Herzig, R. H. Halterman, C. B. Merritt, M. H. McGinniss, G. R.D. Krueger, J. Whang-Peng, R. L. Carolla, D. S. Gullion, M. E. Lippman, H. R. Gralnick, C. W. Berard, P. I. Terasaki, E. S. Henderson

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Eleven HL-A antigen- and mixed leukocyte culture (MLC) -matched sibling bone marrow transplants were attempted in nine multiply transfused acute leukemia patients to define the toxicities of the immunosuppressive regimens and the complications associated with marrow engraftment. All patients but one were considered refractory to conventional chemotherapy. Eight of the nine patients were engrafted as indicated by a change to donor red blood cell (RBC) type, leukocyte karyotype, immunoglobulin allotype, or by the speed of marrow repopulation and/or occurrence of the graft-versus-host reaction (GVHR). The median duration of remission in the patients successfully engrafted was 67 days (range 10-132) and the median survival of all patients following preparation for marrow transplantation was 90 days (20-602). Two of four patients who developed GVHR died in remission. Four patients developed cytomegalovirus (CMV) infection during the post-transplant period.

Original languageEnglish
Pages (from-to)79-90
Number of pages12
JournalTransplantation
Volume14
Issue number1
Publication statusPublished - Jan 1 1972
Externally publishedYes

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Bone Marrow Transplantation
Leukemia
Tissue Donors
Bone Marrow
Transplants
Leukocytes
Immunoglobulin Allotypes
Cytomegalovirus Infections
Immunosuppressive Agents
HLA Antigens
Karyotype
Siblings
Transplantation
Erythrocytes
Drug Therapy
Survival

ASJC Scopus subject areas

  • Transplantation

Cite this

Gbaw, R. G., Yankee, R. A., Rogentine, G. N., Leventhal, B. G., Herzig, G. P., Halterman, R. H., ... Henderson, E. S. (1972). Bone marrow transplantation from HL-A-matched donors to patients with acute leukemia: Toxicity and antileukemic effect. Transplantation, 14(1), 79-90.

Bone marrow transplantation from HL-A-matched donors to patients with acute leukemia : Toxicity and antileukemic effect. / Gbaw, R. G.; Yankee, R. A.; Rogentine, G. N.; Leventhal, B. G.; Herzig, G. P.; Halterman, R. H.; Merritt, C. B.; McGinniss, M. H.; Krueger, G. R.D.; Whang-Peng, J.; Carolla, R. L.; Gullion, D. S.; Lippman, M. E.; Gralnick, H. R.; Berard, C. W.; Terasaki, P. I.; Henderson, E. S.

In: Transplantation, Vol. 14, No. 1, 01.01.1972, p. 79-90.

Research output: Contribution to journalArticle

Gbaw, RG, Yankee, RA, Rogentine, GN, Leventhal, BG, Herzig, GP, Halterman, RH, Merritt, CB, McGinniss, MH, Krueger, GRD, Whang-Peng, J, Carolla, RL, Gullion, DS, Lippman, ME, Gralnick, HR, Berard, CW, Terasaki, PI & Henderson, ES 1972, 'Bone marrow transplantation from HL-A-matched donors to patients with acute leukemia: Toxicity and antileukemic effect', Transplantation, vol. 14, no. 1, pp. 79-90.
Gbaw RG, Yankee RA, Rogentine GN, Leventhal BG, Herzig GP, Halterman RH et al. Bone marrow transplantation from HL-A-matched donors to patients with acute leukemia: Toxicity and antileukemic effect. Transplantation. 1972 Jan 1;14(1):79-90.
Gbaw, R. G. ; Yankee, R. A. ; Rogentine, G. N. ; Leventhal, B. G. ; Herzig, G. P. ; Halterman, R. H. ; Merritt, C. B. ; McGinniss, M. H. ; Krueger, G. R.D. ; Whang-Peng, J. ; Carolla, R. L. ; Gullion, D. S. ; Lippman, M. E. ; Gralnick, H. R. ; Berard, C. W. ; Terasaki, P. I. ; Henderson, E. S. / Bone marrow transplantation from HL-A-matched donors to patients with acute leukemia : Toxicity and antileukemic effect. In: Transplantation. 1972 ; Vol. 14, No. 1. pp. 79-90.
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