Bone marrow transplantation from HL-A-matched donors to patients with acute leukemia: Toxicity and antileukemic effect

R. G. Gbaw; R. A. Yankee; G. N. Rogentine; B. G. Leventhal; G. P. Herzig; R. H. Halterman; C. B. Merritt; M. H. McGinniss; G. R.D. Krueger; J. Whang-Peng; R. L. Carolla; D. S. Gullion; M. E. Lippman; H. R. Gralnick; C. W. Berard; P. I. Terasaki; E. S. Henderson

Bone marrow transplantation from HL-A-matched donors to patients with acute leukemia: Toxicity and antileukemic effect

R. G. Gbaw, R. A. Yankee, G. N. Rogentine, B. G. Leventhal, G. P. Herzig, R. H. Halterman, C. B. Merritt, M. H. McGinniss, G. R.D. Krueger, J. Whang-Peng, R. L. Carolla, D. S. Gullion, M. E. Lippman, H. R. Gralnick, C. W. Berard, P. I. Terasaki, E. S. Henderson

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Eleven HL-A antigen- and mixed leukocyte culture (MLC) -matched sibling bone marrow transplants were attempted in nine multiply transfused acute leukemia patients to define the toxicities of the immunosuppressive regimens and the complications associated with marrow engraftment. All patients but one were considered refractory to conventional chemotherapy. Eight of the nine patients were engrafted as indicated by a change to donor red blood cell (RBC) type, leukocyte karyotype, immunoglobulin allotype, or by the speed of marrow repopulation and/or occurrence of the graft-versus-host reaction (GVHR). The median duration of remission in the patients successfully engrafted was 67 days (range 10-132) and the median survival of all patients following preparation for marrow transplantation was 90 days (20-602). Two of four patients who developed GVHR died in remission. Four patients developed cytomegalovirus (CMV) infection during the post-transplant period.

Original language	English
Pages (from-to)	79-90
Number of pages	12
Journal	Transplantation
Volume	14
Issue number	1
Publication status	Published - Jan 1 1972
Externally published	Yes

ASJC Scopus subject areas

Transplantation

Cite this

Gbaw, R. G., Yankee, R. A., Rogentine, G. N., Leventhal, B. G., Herzig, G. P., Halterman, R. H., Merritt, C. B., McGinniss, M. H., Krueger, G. R. D., Whang-Peng, J., Carolla, R. L., Gullion, D. S., Lippman, M. E., Gralnick, H. R., Berard, C. W., Terasaki, P. I., & Henderson, E. S. (1972). Bone marrow transplantation from HL-A-matched donors to patients with acute leukemia: Toxicity and antileukemic effect. Transplantation, 14(1), 79-90.

Gbaw, RG, Yankee, RA, Rogentine, GN, Leventhal, BG, Herzig, GP, Halterman, RH, Merritt, CB, McGinniss, MH, Krueger, GRD, Whang-Peng, J, Carolla, RL, Gullion, DS, Lippman, ME, Gralnick, HR, Berard, CW, Terasaki, PI & Henderson, ES 1972, 'Bone marrow transplantation from HL-A-matched donors to patients with acute leukemia: Toxicity and antileukemic effect', Transplantation, vol. 14, no. 1, pp. 79-90.

@article{2e984f83d4c74ac7a548b2836c614768,

title = "Bone marrow transplantation from HL-A-matched donors to patients with acute leukemia: Toxicity and antileukemic effect",

abstract = "Eleven HL-A antigen- and mixed leukocyte culture (MLC) -matched sibling bone marrow transplants were attempted in nine multiply transfused acute leukemia patients to define the toxicities of the immunosuppressive regimens and the complications associated with marrow engraftment. All patients but one were considered refractory to conventional chemotherapy. Eight of the nine patients were engrafted as indicated by a change to donor red blood cell (RBC) type, leukocyte karyotype, immunoglobulin allotype, or by the speed of marrow repopulation and/or occurrence of the graft-versus-host reaction (GVHR). The median duration of remission in the patients successfully engrafted was 67 days (range 10-132) and the median survival of all patients following preparation for marrow transplantation was 90 days (20-602). Two of four patients who developed GVHR died in remission. Four patients developed cytomegalovirus (CMV) infection during the post-transplant period.",

author = "Gbaw, {R. G.} and Yankee, {R. A.} and Rogentine, {G. N.} and Leventhal, {B. G.} and Herzig, {G. P.} and Halterman, {R. H.} and Merritt, {C. B.} and McGinniss, {M. H.} and Krueger, {G. R.D.} and J. Whang-Peng and Carolla, {R. L.} and Gullion, {D. S.} and Lippman, {M. E.} and Gralnick, {H. R.} and Berard, {C. W.} and Terasaki, {P. I.} and Henderson, {E. S.}",

year = "1972",

month = jan,

day = "1",

language = "English",

volume = "14",

pages = "79--90",

journal = "Transplantation",

issn = "0041-1337",

publisher = "Lippincott Williams and Wilkins",

number = "1",

}

TY - JOUR

T1 - Bone marrow transplantation from HL-A-matched donors to patients with acute leukemia

T2 - Toxicity and antileukemic effect

AU - Gbaw, R. G.

AU - Yankee, R. A.

AU - Rogentine, G. N.

AU - Leventhal, B. G.

AU - Herzig, G. P.

AU - Halterman, R. H.

AU - Merritt, C. B.

AU - McGinniss, M. H.

AU - Krueger, G. R.D.

AU - Whang-Peng, J.

AU - Carolla, R. L.

AU - Gullion, D. S.

AU - Lippman, M. E.

AU - Gralnick, H. R.

AU - Berard, C. W.

AU - Terasaki, P. I.

AU - Henderson, E. S.

PY - 1972/1/1

Y1 - 1972/1/1

N2 - Eleven HL-A antigen- and mixed leukocyte culture (MLC) -matched sibling bone marrow transplants were attempted in nine multiply transfused acute leukemia patients to define the toxicities of the immunosuppressive regimens and the complications associated with marrow engraftment. All patients but one were considered refractory to conventional chemotherapy. Eight of the nine patients were engrafted as indicated by a change to donor red blood cell (RBC) type, leukocyte karyotype, immunoglobulin allotype, or by the speed of marrow repopulation and/or occurrence of the graft-versus-host reaction (GVHR). The median duration of remission in the patients successfully engrafted was 67 days (range 10-132) and the median survival of all patients following preparation for marrow transplantation was 90 days (20-602). Two of four patients who developed GVHR died in remission. Four patients developed cytomegalovirus (CMV) infection during the post-transplant period.

AB - Eleven HL-A antigen- and mixed leukocyte culture (MLC) -matched sibling bone marrow transplants were attempted in nine multiply transfused acute leukemia patients to define the toxicities of the immunosuppressive regimens and the complications associated with marrow engraftment. All patients but one were considered refractory to conventional chemotherapy. Eight of the nine patients were engrafted as indicated by a change to donor red blood cell (RBC) type, leukocyte karyotype, immunoglobulin allotype, or by the speed of marrow repopulation and/or occurrence of the graft-versus-host reaction (GVHR). The median duration of remission in the patients successfully engrafted was 67 days (range 10-132) and the median survival of all patients following preparation for marrow transplantation was 90 days (20-602). Two of four patients who developed GVHR died in remission. Four patients developed cytomegalovirus (CMV) infection during the post-transplant period.

UR - http://www.scopus.com/inward/record.url?scp=0015372260&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015372260&partnerID=8YFLogxK

M3 - Article

C2 - 4402527

AN - SCOPUS:0015372260

VL - 14

SP - 79

EP - 90

JO - Transplantation

JF - Transplantation

SN - 0041-1337

IS - 1

ER -

Bone marrow transplantation from HL-A-matched donors to patients with acute leukemia: Toxicity and antileukemic effect

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this