Bone marrow involvement as the initial presentation of hodgkin's lymphoma is undetectable by18F-fluorodeoxyglucose positron emission tomography/computed tomography

Chun Chi Lu, Cheng Yi Cheng, Tsu Yi Chao, Ching Liang Ho

Research output: Contribution to journalArticle

Abstract

We report a 28-year-old male who presented with fever and bone pain without peripheral lymphadenopathy observed during initial physical examination. Subsequent bone marrow examination revealed the presence of Reed-Sternberg (RS) cells, which led to a diagnosis of mixed cellularity subtype of Hodgkin's lymphoma (HL). However, the initial 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) scan did not show any detectable marrow or nodal lesions, with the exception of FDG uptake in an extranodal lesion over the right adrenal gland. Two weeks later, a 2-cm enlarged lymph node over the left submandibular region appeared. Excisional biopsy revealed HL. Mixed cellularity subtype of stage IV HL with initial bone marrow and unilateral adrenal gland involvement followed by submandibular lymphadenopathy was diagnosed, according to clinical, imaging, and histological manifestations. This patient received six cycles of chemotherapy with regimen of doxorubincin, bleomycin, vinblastine, and decabazine (ABVD). The subsequent FDG-PET/CT scan revealed complete remission after chemotherapy.

Original languageEnglish
Pages (from-to)209-212
Number of pages4
JournalJournal of Medical Sciences (Taiwan)
Volume28
Issue number5
Publication statusPublished - 2008
Externally publishedYes

Fingerprint

Hodgkin Disease
Bone Marrow
Adrenal Glands
Reed-Sternberg Cells
Bone Marrow Examination
Drug Therapy
Vinblastine
Bleomycin
Fluorodeoxyglucose F18
Physical Examination
Fever
Lymph Nodes
Biopsy
Bone and Bones
Pain
Positron Emission Tomography Computed Tomography
Lymphadenopathy

Keywords

  • F-fluorodeoxyglucose positron emission tomography/computed tomography
  • Bone marrow
  • Hodgkin' lymphoma

ASJC Scopus subject areas

  • Medicine(all)

Cite this

@article{3ba97d5fd4ff443090fb8f5b2acd75fc,
title = "Bone marrow involvement as the initial presentation of hodgkin's lymphoma is undetectable by18F-fluorodeoxyglucose positron emission tomography/computed tomography",
abstract = "We report a 28-year-old male who presented with fever and bone pain without peripheral lymphadenopathy observed during initial physical examination. Subsequent bone marrow examination revealed the presence of Reed-Sternberg (RS) cells, which led to a diagnosis of mixed cellularity subtype of Hodgkin's lymphoma (HL). However, the initial 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) scan did not show any detectable marrow or nodal lesions, with the exception of FDG uptake in an extranodal lesion over the right adrenal gland. Two weeks later, a 2-cm enlarged lymph node over the left submandibular region appeared. Excisional biopsy revealed HL. Mixed cellularity subtype of stage IV HL with initial bone marrow and unilateral adrenal gland involvement followed by submandibular lymphadenopathy was diagnosed, according to clinical, imaging, and histological manifestations. This patient received six cycles of chemotherapy with regimen of doxorubincin, bleomycin, vinblastine, and decabazine (ABVD). The subsequent FDG-PET/CT scan revealed complete remission after chemotherapy.",
keywords = "F-fluorodeoxyglucose positron emission tomography/computed tomography, Bone marrow, Hodgkin' lymphoma",
author = "Lu, {Chun Chi} and Cheng, {Cheng Yi} and Chao, {Tsu Yi} and Ho, {Ching Liang}",
year = "2008",
language = "English",
volume = "28",
pages = "209--212",
journal = "Journal of Medical Sciences",
issn = "1011-4564",
publisher = "國防醫學院",
number = "5",

}

TY - JOUR

T1 - Bone marrow involvement as the initial presentation of hodgkin's lymphoma is undetectable by18F-fluorodeoxyglucose positron emission tomography/computed tomography

AU - Lu, Chun Chi

AU - Cheng, Cheng Yi

AU - Chao, Tsu Yi

AU - Ho, Ching Liang

PY - 2008

Y1 - 2008

N2 - We report a 28-year-old male who presented with fever and bone pain without peripheral lymphadenopathy observed during initial physical examination. Subsequent bone marrow examination revealed the presence of Reed-Sternberg (RS) cells, which led to a diagnosis of mixed cellularity subtype of Hodgkin's lymphoma (HL). However, the initial 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) scan did not show any detectable marrow or nodal lesions, with the exception of FDG uptake in an extranodal lesion over the right adrenal gland. Two weeks later, a 2-cm enlarged lymph node over the left submandibular region appeared. Excisional biopsy revealed HL. Mixed cellularity subtype of stage IV HL with initial bone marrow and unilateral adrenal gland involvement followed by submandibular lymphadenopathy was diagnosed, according to clinical, imaging, and histological manifestations. This patient received six cycles of chemotherapy with regimen of doxorubincin, bleomycin, vinblastine, and decabazine (ABVD). The subsequent FDG-PET/CT scan revealed complete remission after chemotherapy.

AB - We report a 28-year-old male who presented with fever and bone pain without peripheral lymphadenopathy observed during initial physical examination. Subsequent bone marrow examination revealed the presence of Reed-Sternberg (RS) cells, which led to a diagnosis of mixed cellularity subtype of Hodgkin's lymphoma (HL). However, the initial 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) scan did not show any detectable marrow or nodal lesions, with the exception of FDG uptake in an extranodal lesion over the right adrenal gland. Two weeks later, a 2-cm enlarged lymph node over the left submandibular region appeared. Excisional biopsy revealed HL. Mixed cellularity subtype of stage IV HL with initial bone marrow and unilateral adrenal gland involvement followed by submandibular lymphadenopathy was diagnosed, according to clinical, imaging, and histological manifestations. This patient received six cycles of chemotherapy with regimen of doxorubincin, bleomycin, vinblastine, and decabazine (ABVD). The subsequent FDG-PET/CT scan revealed complete remission after chemotherapy.

KW - F-fluorodeoxyglucose positron emission tomography/computed tomography

KW - Bone marrow

KW - Hodgkin' lymphoma

UR - http://www.scopus.com/inward/record.url?scp=77449089407&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77449089407&partnerID=8YFLogxK

M3 - Article

VL - 28

SP - 209

EP - 212

JO - Journal of Medical Sciences

JF - Journal of Medical Sciences

SN - 1011-4564

IS - 5

ER -