Abstract

Chronic kidney disease (CKD) patients experience bone loss and fracture because of a specific CKD-related systemic disorder known as CKD-mineral bone disorder (CKD-MBD). The bone turnover, mineralization, and volume (TMV) system describes the morphological bone lesions in renal osteodystrophy related to CKD-MBD. Bone turnover and bone volume are defined as high, normal, or low, and bone mineralization is classified as normal or abnormal. All types of bone histology related to TMV are responsible for both bone quantity and bone quality losses in CKD patients. This review focuses on current bone quantity and bone quality losses in CKD patients and finally discusses potential therapeutic measures.

Original languageEnglish
Pages (from-to)57-70
Number of pages14
JournalBone
Volume87
DOIs
Publication statusPublished - Jun 1 2016

Fingerprint

Chronic Renal Insufficiency
Bone and Bones
Chronic Kidney Disease-Mineral and Bone Disorder
Physiologic Calcification
Bone Remodeling
Bone Fractures
Histology
Therapeutics

Keywords

  • Bone quantity and bone quality losses
  • Bone remodeling
  • Chronic kidney disease-mineral bone disorder (CKD-MBD)
  • Vitamin D therapy

ASJC Scopus subject areas

  • Physiology
  • Endocrinology, Diabetes and Metabolism
  • Histology

Cite this

Zheng, C. M., Zheng, J. Q., Wu, C. C., Lu, C. L., Shyu, J. F., Yung-Ho, H., ... Lu, K. C. (2016). Bone loss in chronic kidney disease: Quantity or quality? Bone, 87, 57-70. https://doi.org/10.1016/j.bone.2016.03.017

Bone loss in chronic kidney disease : Quantity or quality? / Zheng, Cai Mei; Zheng, Jin Quan; Wu, Chia Chao; Lu, Chien Lin; Shyu, Jia Fwu; Yung-Ho, Hsu; Wu, Mei Yi; Chiu, I. Jen; Wang, Yuan Hung; Lin, Yuh Feng; Lu, Kuo Cheng.

In: Bone, Vol. 87, 01.06.2016, p. 57-70.

Research output: Contribution to journalArticle

Zheng, Cai Mei ; Zheng, Jin Quan ; Wu, Chia Chao ; Lu, Chien Lin ; Shyu, Jia Fwu ; Yung-Ho, Hsu ; Wu, Mei Yi ; Chiu, I. Jen ; Wang, Yuan Hung ; Lin, Yuh Feng ; Lu, Kuo Cheng. / Bone loss in chronic kidney disease : Quantity or quality?. In: Bone. 2016 ; Vol. 87. pp. 57-70.
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