Bone healing improvements using hyaluronic acid and hydroxyapatite/beta-Tricalcium phosphate in combination: An animal study

Yen Lan Chang, Yi June Lo, Sheng Wei Feng, Yu Chih Huang, Hsin Yuan Tsai, Che Tong Lin, Kan Hsin Fan, Haw Ming Huang

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The purpose of this study was to investigate whether the use of HLA as an aqueous binder of hydroxyapatite/beta-Tricalcium phosphate (HA-βTCP) particles can reduce the amount of bone graft needed and increase ease of handling in clinical situations. In this study, HA/βTCP was loaded in commercially available crosslinking HLA to form a novel HLA/HA-βTCP composite. Six New Zealand White rabbits (3.0-3.6 kg) were used as test subjects. Four 6 mm defects were prepared in the parietal bone. The defects were filled with the HLA/HA-βTCP composite as well as HA-βTCP particle alone. New bone formation was analyzed by micro-CT and histomorphometry. Our results indicated that even when the HA-βTCP particle numbers were reduced, the regenerative effect on bone remained when the HLA existed. The bone volume density (BV/TV ratio) of HLA/HA-βTCP samples was 1.7 times larger than that of the control sample at week 2. The new bone increasing ratio (NBIR) of HLA/HA-βTCP samples was 1.78 times higher than the control group at week 2. In conclusion, HA-βTCP powder with HLA contributed to bone healing in rabbit calvarial bone defects. The addition of HLA to bone grafts not only promoted osteoconduction but also improved handling characteristics in clinical situations.

Original languageEnglish
Article number8301624
JournalBioMed Research International
Volume2016
DOIs
Publication statusPublished - 2016

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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