Body temperature control in sepsis-induced acute lung injury

Giueng Chueng Wang, Wei Ming Chi, Wan Cherng Perng, Kun Lun Huang

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Body temperature is precisely regulated to maintain homeostasis in homeothermic animals. Although it remains unproved whether change of body temperature constitutes a beneficial or a detrimental component of the septic response, temperature control should be an important entity in septic experiments. We investigated the effect of body temperature control on the lipopolysaccharide (LPS)-induced lung injury. Acute lung injury in rats was induced by intratracheal spray of LPS and body temperature was either clamped at 37°C for 5 hours or not controlled. The severity of lung injury was evaluated at the end of the experiment. Intratracheal administration of aerosolized LPS caused a persistent decline in body temperature and a significant lung injury as indicated by an elevation of protein concentration and LDH activity in the bronchoalveolar lavage (BAL) fluid and wet/dry weight (W/D) ratio of lungs. Administration of LPS also caused neutrophil sequestration and lipid peroxidation in the lung tissue as indicated by increase in myeloperoxidase (MPO) activity and malondialdehyde (MDA) production, respectively. Control of body temperature at 37°C after LPS (LPS/BT37, n=11) significantly reduced acute lung injury as evidenced by decreases in BAL fluid protein concentration (983±189 vs. 1403±155 mg/L) and LDH activity (56±10 vs. 123±17 ΔmAbs/min) compared with the LPS group (n=11). Although the W/D ratio of lung and MDA level were lower in the rats received temperature control compared with those received LPS only, the differences were not statistically significant. Our results demonstrated that intratracheal administration of aerosolized LPS induced a hypothermic response and acute lung injury in rats and controlling body temperature at a normal range may alleviate the LPS-induced lung injury.

Original languageEnglish
Pages (from-to)151-157
Number of pages7
JournalChinese Journal of Physiology
Volume46
Issue number4
Publication statusPublished - Dec 31 2003
Externally publishedYes

Fingerprint

Acute Lung Injury
Body Temperature
Lipopolysaccharides
Sepsis
Lung Injury
Bronchoalveolar Lavage Fluid
Malondialdehyde
Lung
Body Temperature Changes
Weights and Measures
Temperature
Lipid Peroxidation
Peroxidase
Reference Values
Proteins
Neutrophils
Homeostasis

Keywords

  • Acute lung injury
  • Body temperature
  • Lipopolysaccharide

ASJC Scopus subject areas

  • Physiology

Cite this

Wang, G. C., Chi, W. M., Perng, W. C., & Huang, K. L. (2003). Body temperature control in sepsis-induced acute lung injury. Chinese Journal of Physiology, 46(4), 151-157.

Body temperature control in sepsis-induced acute lung injury. / Wang, Giueng Chueng; Chi, Wei Ming; Perng, Wan Cherng; Huang, Kun Lun.

In: Chinese Journal of Physiology, Vol. 46, No. 4, 31.12.2003, p. 151-157.

Research output: Contribution to journalArticle

Wang, GC, Chi, WM, Perng, WC & Huang, KL 2003, 'Body temperature control in sepsis-induced acute lung injury', Chinese Journal of Physiology, vol. 46, no. 4, pp. 151-157.
Wang, Giueng Chueng ; Chi, Wei Ming ; Perng, Wan Cherng ; Huang, Kun Lun. / Body temperature control in sepsis-induced acute lung injury. In: Chinese Journal of Physiology. 2003 ; Vol. 46, No. 4. pp. 151-157.
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