Body mass index and breast cancer

Analysis of a nation-wide population-based prospective cohort study on 1 393 985 Taiwanese women

M. J. Chen, W. Y Y Wu, A. M F Yen, J. C Y Fann, S. L S Chen, S. Y H Chiu, H. H. Chen, S. T. Chiou

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background:Asian women have a younger age at onset of breast cancer and a lower body mass index (BMI) than Western women. The link between obesity and risk of breast cancer in Asian women is still elusive. We aimed to investigate the effect of BMI on the risk of incident breast cancer in Taiwanese women.Methods:A total of 1 393 985 women who had been cancer-free before recruitment and attended a nation-wide Taiwanese breast cancer-screening program between 1999 and 2009 were enrolled using a prospective cohort study. Obesity and other relevant variables (such as menopause status and other biochemical markers) were collected through in-person interviews, anthropometric measurements and blood samples at first screen. Incident breast cancers during follow-up were ascertained through the linkage of the cohort with the National Cancer Registry and the National Death Certification System.Results:A total of 6969 and 7039 incident breast cancer cases were identified among women enrolled before and after menopause, respectively. Compared with a BMI range of 18.5-23.9 kg m - 2, the incremental level of BMI in the enrolled women before menopause revealed a lack of statistically significant association with the risk of incident breast cancer (adjusted hazard ratio=0.94, 0.98, 1.02, 1.01 and 0.82 for BMI

Original languageEnglish
Pages (from-to)524-530
Number of pages7
JournalInternational Journal of Obesity
Volume40
Issue number3
DOIs
Publication statusPublished - Mar 1 2016

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Body Mass Index
Cohort Studies
Prospective Studies
Breast Neoplasms
Population
Menopause
Obesity
Certification
Early Detection of Cancer
Age of Onset
Registries
Neoplasms
Biomarkers
Interviews

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Endocrinology, Diabetes and Metabolism

Cite this

Body mass index and breast cancer : Analysis of a nation-wide population-based prospective cohort study on 1 393 985 Taiwanese women. / Chen, M. J.; Wu, W. Y Y; Yen, A. M F; Fann, J. C Y; Chen, S. L S; Chiu, S. Y H; Chen, H. H.; Chiou, S. T.

In: International Journal of Obesity, Vol. 40, No. 3, 01.03.2016, p. 524-530.

Research output: Contribution to journalArticle

Chen, M. J. ; Wu, W. Y Y ; Yen, A. M F ; Fann, J. C Y ; Chen, S. L S ; Chiu, S. Y H ; Chen, H. H. ; Chiou, S. T. / Body mass index and breast cancer : Analysis of a nation-wide population-based prospective cohort study on 1 393 985 Taiwanese women. In: International Journal of Obesity. 2016 ; Vol. 40, No. 3. pp. 524-530.
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