Blunted serum erythropoietin response to anemia in patients polytransfused for β-thalassemia major

Jiann Shiuh Chen, Kai Hsin Lin, Shan Tair Wang, Chao Jung Tsao, Tsu Fuh Yeh

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Purpose: To investigate the response of erythropoietin (EPO) to anemia in patients polytransfused for β-thalassemia major. Patients and Methods: We measured the serum EPO levels and the concurrent hemoglobin (Hb) concentrations in 40 patients polytransfused for β-thalassemia major, in 18 patients with iron deficiency anemia (IDA), and 32 healthy subjects. Serum EPO levels were assayed by an enzyme immunoassay. Results: In both groups with β-thalassemia major and IDA, serum EPO levels were significantly elevated (114 ± 71 and 239 ± 217 mU/mL, respectively). There was a significant inverse correlation between log EPO values and Hb concentrations in patients with β-thalassemia major (r = 0.61; p <0.01) and IDA (r = 0.81; p <0.01). In a semilogarithmic plot, the slope of the regression line obtained in patients with β-thalassemia major was significantly lower than that of IDA (p <0.01), suggesting a blunted EPO response to anemia in patients polytransfused for β-thalassemia major. The elevation of serum EPO in patients with β-thalassemia major was poorly related to clinical variables except serum ferritin. Conclusions: We conclude that a significant inverse relationship between serum EPO levels and Hb concentration exists in patients with β-thalassemia major. However, this EPO response in patients with anemia caused by β-thalassemia major may be blunted when compared to patients with IDA.

Original languageEnglish
Pages (from-to)140-144
Number of pages5
JournalJournal of Pediatric Hematology/Oncology
Volume20
Issue number2
DOIs
Publication statusPublished - Mar 1 1998
Externally publishedYes

Keywords

  • β-thalassemia major
  • Erythropoietin

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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