3 Citations (Scopus)

Abstract

Blood transfusion in sub-Saharan Africa (SSA) is at a crossroad. Significant recent developments may help meet local needs in safe blood products and fulfil a global health target, as highlighted by the World Health Organization (WHO) Millennium and Sustainable Development Goals, in improving supply and safety, and ensuring the gradual implementation of selective haemotherapy. When WHO recommended the evaluation of convalescent blood or plasma to treat Ebola-infected patients during the recent epidemics, substantial gaps in local blood collection, testing and technology infrastructure and safety, as compared to best accepted quality standards, became evident. This evidence should now serve as an ‘electro-shock’/awakening call used to highlight the needs for local governments to support National Blood Transfusion Services and establish robust national regulatory authorities that are mandated to bear regulatory responsibilities of blood establishments. A nationally co-ordinated blood programme is the best tool to gather reliable epidemiological data, address local needs in blood and blood products and serve public health. A literature review using WHO website and PubMed was conducted in this article to outline the current clinical use of blood products and plasma derivatives in SSA. This text also intends to highlight the gaps to be filled in the coming years with respect to quality, safety, supply and efficacy of blood and plasma products, in line with WHO guidelines for transfusion. © 2018 International Society of Blood Transfusion
Original languageEnglish
JournalVox Sanguinis
DOIs
Publication statusPublished - 2018

Fingerprint

Africa South of the Sahara
Blood Transfusion
Safety
Local Government
Conservation of Natural Resources
PubMed
Shock
Public Health
Guidelines
Technology

Keywords

  • blood
  • clinical use
  • sub-Saharan Africa
  • transfusion

Cite this

Blood transfusion in sub-Saharan Africa: understanding the missing gap and responding to present and future challenges. / Barro, L.; Drew, V.J.; Poda, G.G.; Tagny, C.T.; El-Ekiaby, M.; Owusu-Ofori, S.; Burnouf, T.

In: Vox Sanguinis, 2018.

Research output: Contribution to journalArticle

Barro, L. ; Drew, V.J. ; Poda, G.G. ; Tagny, C.T. ; El-Ekiaby, M. ; Owusu-Ofori, S. ; Burnouf, T. / Blood transfusion in sub-Saharan Africa: understanding the missing gap and responding to present and future challenges. In: Vox Sanguinis. 2018.
@article{532e5238afc44c3fa195fa87f8e10b63,
title = "Blood transfusion in sub-Saharan Africa: understanding the missing gap and responding to present and future challenges",
abstract = "Blood transfusion in sub-Saharan Africa (SSA) is at a crossroad. Significant recent developments may help meet local needs in safe blood products and fulfil a global health target, as highlighted by the World Health Organization (WHO) Millennium and Sustainable Development Goals, in improving supply and safety, and ensuring the gradual implementation of selective haemotherapy. When WHO recommended the evaluation of convalescent blood or plasma to treat Ebola-infected patients during the recent epidemics, substantial gaps in local blood collection, testing and technology infrastructure and safety, as compared to best accepted quality standards, became evident. This evidence should now serve as an ‘electro-shock’/awakening call used to highlight the needs for local governments to support National Blood Transfusion Services and establish robust national regulatory authorities that are mandated to bear regulatory responsibilities of blood establishments. A nationally co-ordinated blood programme is the best tool to gather reliable epidemiological data, address local needs in blood and blood products and serve public health. A literature review using WHO website and PubMed was conducted in this article to outline the current clinical use of blood products and plasma derivatives in SSA. This text also intends to highlight the gaps to be filled in the coming years with respect to quality, safety, supply and efficacy of blood and plasma products, in line with WHO guidelines for transfusion. {\circledC} 2018 International Society of Blood Transfusion",
keywords = "blood, clinical use, sub-Saharan Africa, transfusion, blood, clinical use, sub-Saharan Africa, transfusion",
author = "L. Barro and V.J. Drew and G.G. Poda and C.T. Tagny and M. El-Ekiaby and S. Owusu-Ofori and T. Burnouf",
note = "Export Date: 25 October 2018 Article in Press CODEN: VOSAA 通訊地址: Burnouf, T.; International Ph.D. Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical UniversityTaiwan; 電子郵件: thburnouf@gmail.com 參考文獻: (2015) Annex 1 - 19th WHO Model List of Essential Medicines (April 2015), , in World Health Organization, (ed)., Geneva, Switzerland, World Health Organization; (2017) Blood products and related biologicals, , http://www.who.int/bloodproducts/en/, Geneva, Switzerland, World Health Organization, Epub ahead of print [,] [Last accessed 25 June 2017]; (2017) Guidelines on management of blood and blood components as essential medicines, , http://apps.who.int/medicinedocs/documents/s23322en/s23322en.pdf, WHO Technical report series, No 1004, 2017., Epub ahead of print [,] [Last accessed 19 June 2018]; Allain, J.P., Goodrich, R., Pathogen reduction of whole blood: utility and feasibility (2017) Transfus Med, 27, pp. 320-326; (2017) The 2016 global status report on blood safety and availability, , Geneva, Switzerland, World Health Organisation; Schneider, W.H., History of blood transfusion in sub-Saharan Africa (2013) Transfus Med Rev, 27, pp. 21-28; Basu, D., Kulkarni, R., Overview of blood components and their preparation (2014) Indian J Anaesth, 58, pp. 529-537; Blajchman, M., Shepherd, F., Perrault, R., Clinical use of blood, blood components and blood products (1979) Can Med Assoc J, 121, p. 33; Team, W.E.R., Ebola virus disease in West Africa—the first 9 months of the epidemic and forward projections (2014) N Engl J Med, 2014, pp. 1481-1495; (2017) Current status on blood safety and availability in the WHO African Region, , http://www.who.int/iris/handle/10665/254656, WHO 2013., Epub ahead of print [,] [Last accessed 21 June 2017]; (2016) 10 Facts on Blood Transfusion, , http://www.who.int/features/factfiles/blood_transfusion/en/, Geneva, Switzerland, World Health Organisation, Epub ahead of print [,] [Last accessed 25 June 2017]; (2015) Blood safety, , http://www.afro.who.int/en/blood-safety.html, Geneva, Switzerland, World Health Organisation, Epub ahead of print [,] [Last accessed 25 June 2017]; Bloch, E.M., Vermeulen, M., Murphy, E., Blood transfusion safety in Africa: a literature review of infectious disease and organizational challenges (2012) Transfus Med Rev, 26, pp. 164-180; (2011) Global database on blood safety (GDBS) reports 2011. World Health Organization, , http://www.who.int/bloodsafety/global_database/GDBS_Summary_Report_2011.pdf?ua=1, Geneva, Switzerland, World Health Organisation, Epub ahead of print [,] [Last accessed 25 June 2017]; Bugge, H., Karlsen, N., Oydna, E., A study of blood transfusion services at a district hospital in Malawi (2013) Vox Sang, 104, pp. 37-45; Tagny, C.T., Mbanya, D., Tapko, J.B., Blood safety in Sub-Saharan Africa: a multi-factorial problem (2008) Transfusion, 48, pp. 1256-1261; Tapko, J., Mainuka, P., Diarra-Nama, A., (2006) Status of Blood Safety in the WHO African Region: Report of the 2006 Survey, , Brazzaville, Republic of Congo, WHO Regional Office for Africa; Ala, F., Allain, J.-P., Bates, I., External financial aid to blood transfusion services in sub-Saharan Africa: a need for reflection (2012) PLoS Med, 9; (2012) Assessment criteria for national blood regulatory systems, , http://www.who.int/bloodproducts/NationalBloodRegSystems.pdf, Geneva, Switzerland, WHO, Epub ahead of print [,] [Last accessed 19 June 2018]; (2018) Vision, Mission and Values of AfSBT – AfSBT. Africa Society for Blood Transfusion, , https://afsbt.org/mission-and-objectives/, Epub ahead of print [,] [Last accessed 20 June 2018]; (2018) ACCREDITATION OVERVIEW - AfSBT. Africa Society for Blood Transfusion, , https://afsbt.org/accreditation-overview/, Epub ahead of print [,] [Last accessed 20 June 2018]; Tagny, C.T., Diarra, A., Yahaya, R., Characteristics of blood donors and donated blood in sub-Saharan Francophone Africa (2009) Transfusion, 49, pp. 1592-1599; Asamoah-Akuoko, L., Hassall, O.W., Bates, I., Blood donors’ perceptions, motivators and deterrents in Sub-Saharan Africa–a scoping review of evidence (2017) Br J Haematol, 177, pp. 864-877; Lara, A.M., Kandulu, J., Chisuwo, L., Laboratory costs of a hospital-based blood transfusion service in Malawi (2007) J Clin Pathol, 60, pp. 1117-1120; Bates, I., Manyasi, G., Lara, A.M., Reducing replacement donors in Sub-Saharan Africa: challenges and affordability (2007) Transfus Med, 17, pp. 434-442; Allain, J.-P., Sibinga, C.T.S., Family donors are critical and legitimate in developing countries (2016) Asian J Transfus Sci, 10, p. 5; (2015) Health in 2015: from MDGs, millennium development goals to SDGs, sustainable development goals, , 215; (2013) General Assembly - U.N. Resolution 67/81, , http://repository.un.org/bitstream/handle/11176/301839/A_RES_67_81-EN.pdf, Global health and foreign policy Epub ahead of print [,]. Washington, USA, United Nations,, p. 6 [Last accessed 23 August 2018]; (2010) WHA resolution 63.12 - Availability, safety and quality of blood products, , http://apps.who.int/gb/ebwha/pdf_files/WHA63/A63_R12-en.pdf, Geneva, World Health Organisation, Epub ahead of print [,]. p. 4 [Last accessed 23 August 2018]; Dahourou, H., Tapko, J.-B., Kienou, K., Recruitment of blood donors in Burkina Faso: how to avoid donations from family members? (2010) Biologicals, 38, pp. 39-42; N{\'e}bi{\'e}, K., Olinger, C., Kafando, E., Lack of knowledge among blood donors in Burkina Faso (West Africa); potential obstacle to transfusion security (2007) Transfus Clin Biol, 14, pp. 446-452; (2017) Activities report 2016, Centre National de Transfusion sanguine, Burkina Faso; Diane, M.K., Dembele, B., Konate, S., Blood collection to cover national needs in sub-Saharan Africa: the reality of the Ivory Coast (2014) Blood Transfus, 12, p. 624; Reddy, R., Blood donation patterns and challenges in Southern Africa (2012) ISBT Sci Ser, 7, pp. 296-299; (2017) Difficult{\'e}s dans la collecte du sang en Guin{\'e}e: le Directeur du CNTS tire la sonnette d'alarme, , Guin{\'e}enews; Lund, T.C., Hume, H., Allain, J.P., The blood supply in Sub-Saharan Africa: needs, challenges, and solutions (2013) Transfus Apheres Sci, 49, pp. 416-421; Osaro, E., Charles, A.T., The challenges of meeting the blood transfusion requirements in Sub-Saharan Africa: the need for the development of alternatives to allogenic blood (2011) J Blood Med, 2, p. 7; Butler, E.K., Hume, H., Birungi, I., Blood utilization at a national referral hospital in sub-Saharan Africa (2015) Transfusion, 55, pp. 1058-1066; Lippi, G., Interference studies: focus on blood cell lysates preparation and testing (2012) Clin Lab, 58, p. 351; Sawadogo, S., N{\'e}bi{\'e}, K., Kafando, E., Preparation of red cell concentrates in low-income countries: efficacy of whole blood settling method by simple gravity in Burkina Faso (2016) Int J Blood Transfu Immunohematol, 6, pp. 20-29; Van Griensven, J., Edwards, T., De Lamballerie, X., Evaluation of convalescent plasma for Ebola virus disease in Guinea (2016) N Engl J Med, 374, pp. 33-42; Brown, J.F., Rowe, K., Zacharias, P., Apheresis for collection of ebola convalescent plasma in Liberia (2017) J Clin Apheresis, 32, pp. 175-181; Ware, A., Jacquot, C., Tobian, A., Pathogen reduction and blood transfusion safety in Africa: strengths, limitations and challenges of implementation in low-resource settings (2017) Vox Sang, 113, pp. 3-12; Bloch, E.M., Shah, A., Kaidarova, Z., A pilot external quality assurance study of transfusion screening for HIV, HCV and HBsAG in 12 African countries (2014) Vox Sang, 107, pp. 333-342; Laperche, S., Transfusion FAGfRiB: multinational assessment of blood-borne virus testing and transfusion safety on the African continent (2013) Transfusion, 53, pp. 816-826; Drew, V.J., Barro, L., Seghatchian, J., Towards pathogen inactivation of red blood cells and whole blood targeting viral DNA/RNA: design, technologies, and future prospects for developing countries (2017) Blood Transfus, 15, pp. 512-521; Allain, J.-P., Owusu-Ofori, A.K., Assennato, S.M., Effect of Plasmodium inactivation in whole blood on the incidence of blood transfusion-transmitted malaria in endemic regions: the African Investigation of the Mirasol System (AIMS) randomised controlled trial (2016) Lancet, 387, pp. 1753-1761; Fast, L.D., Nevola, M., Tavares, J., Treatment of whole blood with riboflavin plus ultraviolet light, an alternative to gamma irradiation in the prevention of transfusion-associated graft-versus-host disease? (2013) Transfusion, 53, pp. 373-381; Owusu-Ofori, S., Allain, J.P., Owusu-Ofori, A., Prevention of transfusion-transmitted malaria (2017) ISBT Sci Ser, 12, pp. 161-167; Marano, G., Vaglio, S., Pupella, S., Convalescent plasma: new evidence for an old therapeutic tool? (2016) Blood Transfus, 14, p. 152; Winkler, A.M., Koepsell, S.A., The use of convalescent plasma to treat emerging infectious diseases: focus on Ebola virus disease (2015) Curr Opin Hematol, 22, pp. 521-526; Mupapa, K., Massamba, M., Kibadi, K., Treatment of Ebola hemorrhagic fever with blood transfusions from convalescent patients. 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Experience from a Nigerian tertiary teaching hospital (2011) Niger Postgrad Med J, 18, pp. 177-181; Figaji, A.A., Zwane, E., Kogels, M., The effect of blood transfusion on brain oxygenation in children with severe traumatic brain injury (2010) Pediatr Crit Care Med, 11, pp. 325-331; Arewa, O., One year clinical audit of the use of blood and blood components at a tertiary hospital in Nigeria (2009) Niger J Clin Pract, 12, pp. 429-433; Avent, M., Cory, B., Galpin, J., A comparison of high versus low dose recombinant human erythropoietin versus blood transfusion in the management of anaemia of prematurity in a developing country (2002) J Trop Pediatr, 48, pp. 227-233",
year = "2018",
doi = "10.1111/vox.12705",
language = "English",
journal = "Vox Sanguinis",
issn = "0042-9007",
publisher = "Blackwell Publishing Ltd",

}

TY - JOUR

T1 - Blood transfusion in sub-Saharan Africa: understanding the missing gap and responding to present and future challenges

AU - Barro, L.

AU - Drew, V.J.

AU - Poda, G.G.

AU - Tagny, C.T.

AU - El-Ekiaby, M.

AU - Owusu-Ofori, S.

AU - Burnouf, T.

N1 - Export Date: 25 October 2018 Article in Press CODEN: VOSAA 通訊地址: Burnouf, T.; International Ph.D. Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical UniversityTaiwan; 電子郵件: thburnouf@gmail.com 參考文獻: (2015) Annex 1 - 19th WHO Model List of Essential Medicines (April 2015), , in World Health Organization, (ed)., Geneva, Switzerland, World Health Organization; (2017) Blood products and related biologicals, , http://www.who.int/bloodproducts/en/, Geneva, Switzerland, World Health Organization, Epub ahead of print [,] [Last accessed 25 June 2017]; (2017) Guidelines on management of blood and blood components as essential medicines, , http://apps.who.int/medicinedocs/documents/s23322en/s23322en.pdf, WHO Technical report series, No 1004, 2017., Epub ahead of print [,] [Last accessed 19 June 2018]; Allain, J.P., Goodrich, R., Pathogen reduction of whole blood: utility and feasibility (2017) Transfus Med, 27, pp. 320-326; (2017) The 2016 global status report on blood safety and availability, , Geneva, Switzerland, World Health Organisation; Schneider, W.H., History of blood transfusion in sub-Saharan Africa (2013) Transfus Med Rev, 27, pp. 21-28; Basu, D., Kulkarni, R., Overview of blood components and their preparation (2014) Indian J Anaesth, 58, pp. 529-537; Blajchman, M., Shepherd, F., Perrault, R., Clinical use of blood, blood components and blood products (1979) Can Med Assoc J, 121, p. 33; Team, W.E.R., Ebola virus disease in West Africa—the first 9 months of the epidemic and forward projections (2014) N Engl J Med, 2014, pp. 1481-1495; (2017) Current status on blood safety and availability in the WHO African Region, , http://www.who.int/iris/handle/10665/254656, WHO 2013., Epub ahead of print [,] [Last accessed 21 June 2017]; (2016) 10 Facts on Blood Transfusion, , http://www.who.int/features/factfiles/blood_transfusion/en/, Geneva, Switzerland, World Health Organisation, Epub ahead of print [,] [Last accessed 25 June 2017]; (2015) Blood safety, , http://www.afro.who.int/en/blood-safety.html, Geneva, Switzerland, World Health Organisation, Epub ahead of print [,] [Last accessed 25 June 2017]; Bloch, E.M., Vermeulen, M., Murphy, E., Blood transfusion safety in Africa: a literature review of infectious disease and organizational challenges (2012) Transfus Med Rev, 26, pp. 164-180; (2011) Global database on blood safety (GDBS) reports 2011. World Health Organization, , http://www.who.int/bloodsafety/global_database/GDBS_Summary_Report_2011.pdf?ua=1, Geneva, Switzerland, World Health Organisation, Epub ahead of print [,] [Last accessed 25 June 2017]; Bugge, H., Karlsen, N., Oydna, E., A study of blood transfusion services at a district hospital in Malawi (2013) Vox Sang, 104, pp. 37-45; Tagny, C.T., Mbanya, D., Tapko, J.B., Blood safety in Sub-Saharan Africa: a multi-factorial problem (2008) Transfusion, 48, pp. 1256-1261; Tapko, J., Mainuka, P., Diarra-Nama, A., (2006) Status of Blood Safety in the WHO African Region: Report of the 2006 Survey, , Brazzaville, Republic of Congo, WHO Regional Office for Africa; Ala, F., Allain, J.-P., Bates, I., External financial aid to blood transfusion services in sub-Saharan Africa: a need for reflection (2012) PLoS Med, 9; (2012) Assessment criteria for national blood regulatory systems, , http://www.who.int/bloodproducts/NationalBloodRegSystems.pdf, Geneva, Switzerland, WHO, Epub ahead of print [,] [Last accessed 19 June 2018]; (2018) Vision, Mission and Values of AfSBT – AfSBT. Africa Society for Blood Transfusion, , https://afsbt.org/mission-and-objectives/, Epub ahead of print [,] [Last accessed 20 June 2018]; (2018) ACCREDITATION OVERVIEW - AfSBT. Africa Society for Blood Transfusion, , https://afsbt.org/accreditation-overview/, Epub ahead of print [,] [Last accessed 20 June 2018]; Tagny, C.T., Diarra, A., Yahaya, R., Characteristics of blood donors and donated blood in sub-Saharan Francophone Africa (2009) Transfusion, 49, pp. 1592-1599; Asamoah-Akuoko, L., Hassall, O.W., Bates, I., Blood donors’ perceptions, motivators and deterrents in Sub-Saharan Africa–a scoping review of evidence (2017) Br J Haematol, 177, pp. 864-877; Lara, A.M., Kandulu, J., Chisuwo, L., Laboratory costs of a hospital-based blood transfusion service in Malawi (2007) J Clin Pathol, 60, pp. 1117-1120; Bates, I., Manyasi, G., Lara, A.M., Reducing replacement donors in Sub-Saharan Africa: challenges and affordability (2007) Transfus Med, 17, pp. 434-442; Allain, J.-P., Sibinga, C.T.S., Family donors are critical and legitimate in developing countries (2016) Asian J Transfus Sci, 10, p. 5; (2015) Health in 2015: from MDGs, millennium development goals to SDGs, sustainable development goals, , 215; (2013) General Assembly - U.N. Resolution 67/81, , http://repository.un.org/bitstream/handle/11176/301839/A_RES_67_81-EN.pdf, Global health and foreign policy Epub ahead of print [,]. Washington, USA, United Nations,, p. 6 [Last accessed 23 August 2018]; (2010) WHA resolution 63.12 - Availability, safety and quality of blood products, , http://apps.who.int/gb/ebwha/pdf_files/WHA63/A63_R12-en.pdf, Geneva, World Health Organisation, Epub ahead of print [,]. p. 4 [Last accessed 23 August 2018]; Dahourou, H., Tapko, J.-B., Kienou, K., Recruitment of blood donors in Burkina Faso: how to avoid donations from family members? (2010) Biologicals, 38, pp. 39-42; Nébié, K., Olinger, C., Kafando, E., Lack of knowledge among blood donors in Burkina Faso (West Africa); potential obstacle to transfusion security (2007) Transfus Clin Biol, 14, pp. 446-452; (2017) Activities report 2016, Centre National de Transfusion sanguine, Burkina Faso; Diane, M.K., Dembele, B., Konate, S., Blood collection to cover national needs in sub-Saharan Africa: the reality of the Ivory Coast (2014) Blood Transfus, 12, p. 624; Reddy, R., Blood donation patterns and challenges in Southern Africa (2012) ISBT Sci Ser, 7, pp. 296-299; (2017) Difficultés dans la collecte du sang en Guinée: le Directeur du CNTS tire la sonnette d'alarme, , Guinéenews; Lund, T.C., Hume, H., Allain, J.P., The blood supply in Sub-Saharan Africa: needs, challenges, and solutions (2013) Transfus Apheres Sci, 49, pp. 416-421; Osaro, E., Charles, A.T., The challenges of meeting the blood transfusion requirements in Sub-Saharan Africa: the need for the development of alternatives to allogenic blood (2011) J Blood Med, 2, p. 7; Butler, E.K., Hume, H., Birungi, I., Blood utilization at a national referral hospital in sub-Saharan Africa (2015) Transfusion, 55, pp. 1058-1066; Lippi, G., Interference studies: focus on blood cell lysates preparation and testing (2012) Clin Lab, 58, p. 351; Sawadogo, S., Nébié, K., Kafando, E., Preparation of red cell concentrates in low-income countries: efficacy of whole blood settling method by simple gravity in Burkina Faso (2016) Int J Blood Transfu Immunohematol, 6, pp. 20-29; Van Griensven, J., Edwards, T., De Lamballerie, X., Evaluation of convalescent plasma for Ebola virus disease in Guinea (2016) N Engl J Med, 374, pp. 33-42; Brown, J.F., Rowe, K., Zacharias, P., Apheresis for collection of ebola convalescent plasma in Liberia (2017) J Clin Apheresis, 32, pp. 175-181; Ware, A., Jacquot, C., Tobian, A., Pathogen reduction and blood transfusion safety in Africa: strengths, limitations and challenges of implementation in low-resource settings (2017) Vox Sang, 113, pp. 3-12; Bloch, E.M., Shah, A., Kaidarova, Z., A pilot external quality assurance study of transfusion screening for HIV, HCV and HBsAG in 12 African countries (2014) Vox Sang, 107, pp. 333-342; Laperche, S., Transfusion FAGfRiB: multinational assessment of blood-borne virus testing and transfusion safety on the African continent (2013) Transfusion, 53, pp. 816-826; Drew, V.J., Barro, L., Seghatchian, J., Towards pathogen inactivation of red blood cells and whole blood targeting viral DNA/RNA: design, technologies, and future prospects for developing countries (2017) Blood Transfus, 15, pp. 512-521; Allain, J.-P., Owusu-Ofori, A.K., Assennato, S.M., Effect of Plasmodium inactivation in whole blood on the incidence of blood transfusion-transmitted malaria in endemic regions: the African Investigation of the Mirasol System (AIMS) randomised controlled trial (2016) Lancet, 387, pp. 1753-1761; Fast, L.D., Nevola, M., Tavares, J., Treatment of whole blood with riboflavin plus ultraviolet light, an alternative to gamma irradiation in the prevention of transfusion-associated graft-versus-host disease? 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PY - 2018

Y1 - 2018

N2 - Blood transfusion in sub-Saharan Africa (SSA) is at a crossroad. Significant recent developments may help meet local needs in safe blood products and fulfil a global health target, as highlighted by the World Health Organization (WHO) Millennium and Sustainable Development Goals, in improving supply and safety, and ensuring the gradual implementation of selective haemotherapy. When WHO recommended the evaluation of convalescent blood or plasma to treat Ebola-infected patients during the recent epidemics, substantial gaps in local blood collection, testing and technology infrastructure and safety, as compared to best accepted quality standards, became evident. This evidence should now serve as an ‘electro-shock’/awakening call used to highlight the needs for local governments to support National Blood Transfusion Services and establish robust national regulatory authorities that are mandated to bear regulatory responsibilities of blood establishments. A nationally co-ordinated blood programme is the best tool to gather reliable epidemiological data, address local needs in blood and blood products and serve public health. A literature review using WHO website and PubMed was conducted in this article to outline the current clinical use of blood products and plasma derivatives in SSA. This text also intends to highlight the gaps to be filled in the coming years with respect to quality, safety, supply and efficacy of blood and plasma products, in line with WHO guidelines for transfusion. © 2018 International Society of Blood Transfusion

AB - Blood transfusion in sub-Saharan Africa (SSA) is at a crossroad. Significant recent developments may help meet local needs in safe blood products and fulfil a global health target, as highlighted by the World Health Organization (WHO) Millennium and Sustainable Development Goals, in improving supply and safety, and ensuring the gradual implementation of selective haemotherapy. When WHO recommended the evaluation of convalescent blood or plasma to treat Ebola-infected patients during the recent epidemics, substantial gaps in local blood collection, testing and technology infrastructure and safety, as compared to best accepted quality standards, became evident. This evidence should now serve as an ‘electro-shock’/awakening call used to highlight the needs for local governments to support National Blood Transfusion Services and establish robust national regulatory authorities that are mandated to bear regulatory responsibilities of blood establishments. A nationally co-ordinated blood programme is the best tool to gather reliable epidemiological data, address local needs in blood and blood products and serve public health. A literature review using WHO website and PubMed was conducted in this article to outline the current clinical use of blood products and plasma derivatives in SSA. This text also intends to highlight the gaps to be filled in the coming years with respect to quality, safety, supply and efficacy of blood and plasma products, in line with WHO guidelines for transfusion. © 2018 International Society of Blood Transfusion

KW - blood

KW - clinical use

KW - sub-Saharan Africa

KW - transfusion

KW - blood

KW - clinical use

KW - sub-Saharan Africa

KW - transfusion

U2 - 10.1111/vox.12705

DO - 10.1111/vox.12705

M3 - Article

JO - Vox Sanguinis

JF - Vox Sanguinis

SN - 0042-9007

ER -