Blood profile of oral mucosal disease patients with both vitamin B12 and iron deficiencies

Julia Yu Fong Chang, Yi Ping Wang, Yang Che Wu, Shih Jung Cheng, Hsin Ming Chen, Andy Sun

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Background/Purpose: Vitamin B12 and iron deficiencies lead to macrocytosis [mean corpuscular volume (MCV)<100fL] and microcytosis (MCV<80fL), respectively. This study evaluated anemic status, MCV, serum homocysteine level, and serum gastric parietal cell antibody (GPCA) level in oral mucosal disease patients with both vitamin B12 and iron deficiencies. Methods: The blood hemoglobin (Hb), iron, vitamin B12, folic acid and homocysteine concentrations, MCV, and serum GPCA in 149 patients with both vitamin B12 and iron deficiencies were measured and compared with the corresponding data in 149 age- and sex-matched healthy control subjects. Results: We found that 54 (36.2%), 16 (10.7%), 44 (29.5%), and 36 (24.2%) patients with both vitamin B12 and iron deficiencies had Hb deficiency (men <13g/dL, women <12g/dL), folic acid deficiency (≤6mg/mL), abnormally high blood homocysteine level (>12.6μM), and serum GPCA positivity, respectively. Patients with both vitamin B12 and iron deficiencies had a significantly higher frequency of Hb deficiency, abnormally elevated blood homocysteine level, and serum GPCA positivity than healthy control subjects (all p values<0.001). Of 149 patients with both vitamin B12 and iron deficiencies, 10 (6.7%) had high MCV (<100fL), 108 (72.5%) had normal MCV (between 80fL and 99fL), and 31 (20.8%) had low MCV (<80fL). Conclusion: Approximately 73%, 30%, and 24% of patients with both vitamin B12 and iron deficiencies are found to have normal MCV, abnormally high blood homocysteine level, and serum GPCA positivity, respectively.

Original languageEnglish
Pages (from-to)532-538
Number of pages7
JournalJournal of the Formosan Medical Association
Volume114
Issue number6
DOIs
Publication statusPublished - Jun 1 2015
Externally publishedYes

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Mouth Diseases
Vitamin B 12 Deficiency
Erythrocyte Indices
Iron
Homocysteine
Serum
Healthy Volunteers

Keywords

  • Gastric parietal cell antibody
  • Iron deficiency
  • Macrocytosis
  • Mean corpuscular volume
  • Microcytosis
  • Vitamin B<inf>12</inf> deficiency

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Blood profile of oral mucosal disease patients with both vitamin B12 and iron deficiencies. / Chang, Julia Yu Fong; Wang, Yi Ping; Wu, Yang Che; Cheng, Shih Jung; Chen, Hsin Ming; Sun, Andy.

In: Journal of the Formosan Medical Association, Vol. 114, No. 6, 01.06.2015, p. 532-538.

Research output: Contribution to journalArticle

Chang, Julia Yu Fong ; Wang, Yi Ping ; Wu, Yang Che ; Cheng, Shih Jung ; Chen, Hsin Ming ; Sun, Andy. / Blood profile of oral mucosal disease patients with both vitamin B12 and iron deficiencies. In: Journal of the Formosan Medical Association. 2015 ; Vol. 114, No. 6. pp. 532-538.
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abstract = "Background/Purpose: Vitamin B12 and iron deficiencies lead to macrocytosis [mean corpuscular volume (MCV)<100fL] and microcytosis (MCV<80fL), respectively. This study evaluated anemic status, MCV, serum homocysteine level, and serum gastric parietal cell antibody (GPCA) level in oral mucosal disease patients with both vitamin B12 and iron deficiencies. Methods: The blood hemoglobin (Hb), iron, vitamin B12, folic acid and homocysteine concentrations, MCV, and serum GPCA in 149 patients with both vitamin B12 and iron deficiencies were measured and compared with the corresponding data in 149 age- and sex-matched healthy control subjects. Results: We found that 54 (36.2{\%}), 16 (10.7{\%}), 44 (29.5{\%}), and 36 (24.2{\%}) patients with both vitamin B12 and iron deficiencies had Hb deficiency (men <13g/dL, women <12g/dL), folic acid deficiency (≤6mg/mL), abnormally high blood homocysteine level (>12.6μM), and serum GPCA positivity, respectively. Patients with both vitamin B12 and iron deficiencies had a significantly higher frequency of Hb deficiency, abnormally elevated blood homocysteine level, and serum GPCA positivity than healthy control subjects (all p values<0.001). Of 149 patients with both vitamin B12 and iron deficiencies, 10 (6.7{\%}) had high MCV (<100fL), 108 (72.5{\%}) had normal MCV (between 80fL and 99fL), and 31 (20.8{\%}) had low MCV (<80fL). Conclusion: Approximately 73{\%}, 30{\%}, and 24{\%} of patients with both vitamin B12 and iron deficiencies are found to have normal MCV, abnormally high blood homocysteine level, and serum GPCA positivity, respectively.",
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AU - Wang, Yi Ping

AU - Wu, Yang Che

AU - Cheng, Shih Jung

AU - Chen, Hsin Ming

AU - Sun, Andy

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AB - Background/Purpose: Vitamin B12 and iron deficiencies lead to macrocytosis [mean corpuscular volume (MCV)<100fL] and microcytosis (MCV<80fL), respectively. This study evaluated anemic status, MCV, serum homocysteine level, and serum gastric parietal cell antibody (GPCA) level in oral mucosal disease patients with both vitamin B12 and iron deficiencies. Methods: The blood hemoglobin (Hb), iron, vitamin B12, folic acid and homocysteine concentrations, MCV, and serum GPCA in 149 patients with both vitamin B12 and iron deficiencies were measured and compared with the corresponding data in 149 age- and sex-matched healthy control subjects. Results: We found that 54 (36.2%), 16 (10.7%), 44 (29.5%), and 36 (24.2%) patients with both vitamin B12 and iron deficiencies had Hb deficiency (men <13g/dL, women <12g/dL), folic acid deficiency (≤6mg/mL), abnormally high blood homocysteine level (>12.6μM), and serum GPCA positivity, respectively. Patients with both vitamin B12 and iron deficiencies had a significantly higher frequency of Hb deficiency, abnormally elevated blood homocysteine level, and serum GPCA positivity than healthy control subjects (all p values<0.001). Of 149 patients with both vitamin B12 and iron deficiencies, 10 (6.7%) had high MCV (<100fL), 108 (72.5%) had normal MCV (between 80fL and 99fL), and 31 (20.8%) had low MCV (<80fL). Conclusion: Approximately 73%, 30%, and 24% of patients with both vitamin B12 and iron deficiencies are found to have normal MCV, abnormally high blood homocysteine level, and serum GPCA positivity, respectively.

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KW - Microcytosis

KW - Vitamin B<inf>12</inf> deficiency

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