Blood profile of atrophic glossitis patients with thyroglobulin antibody/thyroid microsomal antibody positivity but without gastric parietal cell antibody positivity

Ying Shiung Kuo, Yu Hsueh Wu, Julia Yu Fong Chang, Yi Ping Wang, Yang Che Wu, Andy Sun

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background/purpose: Our previous study found that 304 of 1064 atrophic glossitis (AG) patients have thyroglobulin antibody (TGA) positivity and/or thyroid microsomal antibody (TMA) positivity but without gastric parietal cell antibody positivity (GPCA־TGA + /TMA + AG patients). This study mainly assessed whether the serum TGA/TMA positivity was significantly associated with anemia, hematinic deficiencies, and hyperhomocysteinemia in GPCA־TGA + /TMA + AG patients. Methods: The mean blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine levels were measured and compared between 304 GPCA־TGA + /TMA + AG patients and 476 GPCA-negative, TGA-negative, and TMA-negative AG patients (GPCA־TGA־TMA־AG patients) or 532 healthy control subjects. Results: We found significantly lower MCV and lower mean blood Hb and iron levels as well as significantly greater frquencies of microcytosis, macrocytosis, blood Hb, iron, vitamin B12, and folic acid deficiencies and hyperhomocysteinemia in 304 GPCA־TGA + /TMA + AG patients than in 532 healthy control subjects. However, no significant differences in the MCV and mean blood Hb, iron, vitamin B12, folic acid, and homocysteine leve1s as well as no significant differences in the frequencies of microcytosis, macrocytosis, blood Hb, iron, and folic acid deficiencies, and hyperhomocysteinemia were discovered between 304 GPCA־TGA + /TMA + AG patients and 476 GPCA־TGA־TMA־AG patients. The 304 GPCA־TGA + /TMA + AG patients had a significantly greater frquency of serum vitamin B12 deficiency than 476 GPCA־TGA־TMA־AG patients. Conclusion: The disease of AG itself plays a significant role in causing anemia, hematinic deficiencies, and hyperhomocysteinemia in GPCA־TGA + /TMA + AG patients. However, the serum TGA/TMA-positivity is not significantly associated with anemia, serum iron and folic acid deficiencies, and hyperhomocysteinemia in GPCA־TGA + /TMA + AG patients.

Original languageEnglish
JournalJournal of the Formosan Medical Association
DOIs
Publication statusPublished - Jan 1 2019
Externally publishedYes

Fingerprint

Glossitis
Gastric Parietal Cells
Thyroglobulin
Antibodies
Hyperhomocysteinemia
Iron
Folic Acid Deficiency
Hemoglobins
Vitamin B 12
Hematinics
Anemia
Homocysteine
Serum
Folic Acid
thyroid microsomal antibodies
Healthy Volunteers
Vitamin B 12 Deficiency

Keywords

  • Atrophic glossitis
  • Folic acid deficiency
  • Hyperhomocysteinemia
  • Iron deficiency
  • Thyroglobulin antibody
  • Thyroid microsomal antibody

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Blood profile of atrophic glossitis patients with thyroglobulin antibody/thyroid microsomal antibody positivity but without gastric parietal cell antibody positivity. / Kuo, Ying Shiung; Wu, Yu Hsueh; Chang, Julia Yu Fong; Wang, Yi Ping; Wu, Yang Che; Sun, Andy.

In: Journal of the Formosan Medical Association, 01.01.2019.

Research output: Contribution to journalArticle

@article{80bced4ae83442f8bc54abdfe81603ae,
title = "Blood profile of atrophic glossitis patients with thyroglobulin antibody/thyroid microsomal antibody positivity but without gastric parietal cell antibody positivity",
abstract = "Background/purpose: Our previous study found that 304 of 1064 atrophic glossitis (AG) patients have thyroglobulin antibody (TGA) positivity and/or thyroid microsomal antibody (TMA) positivity but without gastric parietal cell antibody positivity (GPCA־TGA + /TMA + AG patients). This study mainly assessed whether the serum TGA/TMA positivity was significantly associated with anemia, hematinic deficiencies, and hyperhomocysteinemia in GPCA־TGA + /TMA + AG patients. Methods: The mean blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine levels were measured and compared between 304 GPCA־TGA + /TMA + AG patients and 476 GPCA-negative, TGA-negative, and TMA-negative AG patients (GPCA־TGA־TMA־AG patients) or 532 healthy control subjects. Results: We found significantly lower MCV and lower mean blood Hb and iron levels as well as significantly greater frquencies of microcytosis, macrocytosis, blood Hb, iron, vitamin B12, and folic acid deficiencies and hyperhomocysteinemia in 304 GPCA־TGA + /TMA + AG patients than in 532 healthy control subjects. However, no significant differences in the MCV and mean blood Hb, iron, vitamin B12, folic acid, and homocysteine leve1s as well as no significant differences in the frequencies of microcytosis, macrocytosis, blood Hb, iron, and folic acid deficiencies, and hyperhomocysteinemia were discovered between 304 GPCA־TGA + /TMA + AG patients and 476 GPCA־TGA־TMA־AG patients. The 304 GPCA־TGA + /TMA + AG patients had a significantly greater frquency of serum vitamin B12 deficiency than 476 GPCA־TGA־TMA־AG patients. Conclusion: The disease of AG itself plays a significant role in causing anemia, hematinic deficiencies, and hyperhomocysteinemia in GPCA־TGA + /TMA + AG patients. However, the serum TGA/TMA-positivity is not significantly associated with anemia, serum iron and folic acid deficiencies, and hyperhomocysteinemia in GPCA־TGA + /TMA + AG patients.",
keywords = "Atrophic glossitis, Folic acid deficiency, Hyperhomocysteinemia, Iron deficiency, Thyroglobulin antibody, Thyroid microsomal antibody",
author = "Kuo, {Ying Shiung} and Wu, {Yu Hsueh} and Chang, {Julia Yu Fong} and Wang, {Yi Ping} and Wu, {Yang Che} and Andy Sun",
year = "2019",
month = "1",
day = "1",
doi = "10.1016/j.jfma.2019.04.002",
language = "English",
journal = "Journal of the Formosan Medical Association",
issn = "0929-6646",
publisher = "Elsevier Science Publishers B.V.",

}

TY - JOUR

T1 - Blood profile of atrophic glossitis patients with thyroglobulin antibody/thyroid microsomal antibody positivity but without gastric parietal cell antibody positivity

AU - Kuo, Ying Shiung

AU - Wu, Yu Hsueh

AU - Chang, Julia Yu Fong

AU - Wang, Yi Ping

AU - Wu, Yang Che

AU - Sun, Andy

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background/purpose: Our previous study found that 304 of 1064 atrophic glossitis (AG) patients have thyroglobulin antibody (TGA) positivity and/or thyroid microsomal antibody (TMA) positivity but without gastric parietal cell antibody positivity (GPCA־TGA + /TMA + AG patients). This study mainly assessed whether the serum TGA/TMA positivity was significantly associated with anemia, hematinic deficiencies, and hyperhomocysteinemia in GPCA־TGA + /TMA + AG patients. Methods: The mean blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine levels were measured and compared between 304 GPCA־TGA + /TMA + AG patients and 476 GPCA-negative, TGA-negative, and TMA-negative AG patients (GPCA־TGA־TMA־AG patients) or 532 healthy control subjects. Results: We found significantly lower MCV and lower mean blood Hb and iron levels as well as significantly greater frquencies of microcytosis, macrocytosis, blood Hb, iron, vitamin B12, and folic acid deficiencies and hyperhomocysteinemia in 304 GPCA־TGA + /TMA + AG patients than in 532 healthy control subjects. However, no significant differences in the MCV and mean blood Hb, iron, vitamin B12, folic acid, and homocysteine leve1s as well as no significant differences in the frequencies of microcytosis, macrocytosis, blood Hb, iron, and folic acid deficiencies, and hyperhomocysteinemia were discovered between 304 GPCA־TGA + /TMA + AG patients and 476 GPCA־TGA־TMA־AG patients. The 304 GPCA־TGA + /TMA + AG patients had a significantly greater frquency of serum vitamin B12 deficiency than 476 GPCA־TGA־TMA־AG patients. Conclusion: The disease of AG itself plays a significant role in causing anemia, hematinic deficiencies, and hyperhomocysteinemia in GPCA־TGA + /TMA + AG patients. However, the serum TGA/TMA-positivity is not significantly associated with anemia, serum iron and folic acid deficiencies, and hyperhomocysteinemia in GPCA־TGA + /TMA + AG patients.

AB - Background/purpose: Our previous study found that 304 of 1064 atrophic glossitis (AG) patients have thyroglobulin antibody (TGA) positivity and/or thyroid microsomal antibody (TMA) positivity but without gastric parietal cell antibody positivity (GPCA־TGA + /TMA + AG patients). This study mainly assessed whether the serum TGA/TMA positivity was significantly associated with anemia, hematinic deficiencies, and hyperhomocysteinemia in GPCA־TGA + /TMA + AG patients. Methods: The mean blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine levels were measured and compared between 304 GPCA־TGA + /TMA + AG patients and 476 GPCA-negative, TGA-negative, and TMA-negative AG patients (GPCA־TGA־TMA־AG patients) or 532 healthy control subjects. Results: We found significantly lower MCV and lower mean blood Hb and iron levels as well as significantly greater frquencies of microcytosis, macrocytosis, blood Hb, iron, vitamin B12, and folic acid deficiencies and hyperhomocysteinemia in 304 GPCA־TGA + /TMA + AG patients than in 532 healthy control subjects. However, no significant differences in the MCV and mean blood Hb, iron, vitamin B12, folic acid, and homocysteine leve1s as well as no significant differences in the frequencies of microcytosis, macrocytosis, blood Hb, iron, and folic acid deficiencies, and hyperhomocysteinemia were discovered between 304 GPCA־TGA + /TMA + AG patients and 476 GPCA־TGA־TMA־AG patients. The 304 GPCA־TGA + /TMA + AG patients had a significantly greater frquency of serum vitamin B12 deficiency than 476 GPCA־TGA־TMA־AG patients. Conclusion: The disease of AG itself plays a significant role in causing anemia, hematinic deficiencies, and hyperhomocysteinemia in GPCA־TGA + /TMA + AG patients. However, the serum TGA/TMA-positivity is not significantly associated with anemia, serum iron and folic acid deficiencies, and hyperhomocysteinemia in GPCA־TGA + /TMA + AG patients.

KW - Atrophic glossitis

KW - Folic acid deficiency

KW - Hyperhomocysteinemia

KW - Iron deficiency

KW - Thyroglobulin antibody

KW - Thyroid microsomal antibody

UR - http://www.scopus.com/inward/record.url?scp=85064278333&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85064278333&partnerID=8YFLogxK

U2 - 10.1016/j.jfma.2019.04.002

DO - 10.1016/j.jfma.2019.04.002

M3 - Article

AN - SCOPUS:85064278333

JO - Journal of the Formosan Medical Association

JF - Journal of the Formosan Medical Association

SN - 0929-6646

ER -