Blood-derived biomaterials

What role can they play in regenerative medicine and stem cell therapy?

Chen Yao Su, Thierry Burnouf

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

There is a growing clinical interest in regenerative medicine and stem cell therapies in the use of biomaterials made from human autologous (or allogeneic) blood because these products do not induce tissue reaction, are biodegradable and exhibit valuable physiological functions. The fi rst generation of blood-derived biomaterials called fi brin sealant, or fi brin glue, obtained by mixing a fi brinogen-rich fraction with thrombin were developed in the early 1900‘s and became available for routine clinical use in the 1980‘s in Europe and, later, in the USA (Radosevich et al. 1997, Jackson et al. 1996, Martinowitz and Saltz 1996, Spotnitz 2001, Mintz et al. 2001, Spotnitz and Prabhu 2005, Burnouf et al. 2009). Those glue-like sealants exhibit hemostatic and sealing properties. Both industrial and single-donor 1Department of Dentistry, National Yang-Ming University, Taipei, Taiwan. Email: henrycysu@gmail.com 2College of Oral Medicine, Taipei Medical University, Taipei, Taiwan & Human Protein Process Sciences (HPPS), Lille, France. &z.ast;Corresponding author fi brin sealants are currently available for use in many fi elds such as cardiac, plastic, oral, orthopedic, aesthetic, and implant surgeries (Radosevich et al. 1997, Burnouf et al. 2009). A second group of blood-derived biomaterials, called platelet gels (PLT gels), encompasses different types of products, depending upon their mode of preparation (Jackson et al. 1996, Burnouf et al. 2009, Everts et al. 2006a, Borzini and Mazzuco 2005, Marx 2001, Marx 2004). These are single-donor (usually autologous, more rarely allogenic) products obtained by combining platelet-rich plasma (PRP) with thrombin. The mixing of both fractions results in (a) the conversion of fi brinogen into fi brin, (b) the activation of platelets and (c) the release of a myriad of growth factors (GF) stored in the platelet a-granules (Blair and Flaumenhaft 2009). Upon activation by exogenous or endogenous agonists, platelets release a myriad of functional molecules which play a key role in tissue repair and regeneration by stimulation and differentiation of local stem cells (Marx et al. 1998). Among these are the numerous growth factors entrapped within alpha-granules: platelet-derived growth factors (PDGF) -AA, -BB, or -AB, transforming growth factor-(TGF- and -2), vascular endothelium growth factor (VEGF), epidermal growth factor (EGF), fi broblast growth factor-1 (FGF-1), brain-derived neurotrophic factor (BDNF), etc. Human platelet growth factors are now explored and proven to be unique non-toxic biocompatible tools for tissue engineering, stem cell expansion in vitro and cell therapy. GF-rich biomaterials, combined, or not, with fi brin glue, can be used as matrix for cell cultures (chondrocytes, keratinocytes, etc.) prior to implant. They can also be used as cell carriers for in vivo delivery to damaged tissues, e.g., for the healing of soft and hard tissues. Understandably, human platelet lysates rich in growth factors and other bioactive molecules are increasingly used successfully as a medium supplement to replace fetal bovine serum for the expansion of mesenchymal stem cells from various origins, opening new perspectives for the clinical development of stem cellbased cell therapy (Kazemnejad et al. 2008, Doucet et al. 2005, Vogel et al. 2006, Schallmoser and Strunk 2009, Kocaoemer et al. 2007, Shih et al. 2011). In this chapter, we present the four main categories of biomaterials made from human blood and their specifi city in biochemical and physiological properties as well as their clinical applications in particular in the fi eld of regenerative medicine and cell therapy. The main characteristics of these four biomaterials are summarized in Table 3.1.

Original languageEnglish
Title of host publicationBiomaterials for Stem Cell Therapy
Subtitle of host publicationState of Art and Vision for the Future
PublisherCRC Press/Balkema
Pages65-86
Number of pages22
ISBN (Electronic)9781466576407
ISBN (Print)9781466576391
DOIs
Publication statusPublished - Jan 1 2013

Fingerprint

Regenerative Medicine
Biocompatible Materials
Cell- and Tissue-Based Therapy
Platelets
Stem cells
Biomaterials
Intercellular Signaling Peptides and Proteins
Blood
Stem Cells
Blood Platelets
Glues
Sealants
Adhesives
Tissue
Taiwan
Thrombin
Chemical activation
Dentistry
Oral Medicine
Molecules

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Engineering(all)
  • Materials Science(all)
  • Medicine(all)

Cite this

Su, C. Y., & Burnouf, T. (2013). Blood-derived biomaterials: What role can they play in regenerative medicine and stem cell therapy? In Biomaterials for Stem Cell Therapy: State of Art and Vision for the Future (pp. 65-86). CRC Press/Balkema. https://doi.org/10.1201/b14584

Blood-derived biomaterials : What role can they play in regenerative medicine and stem cell therapy? / Su, Chen Yao; Burnouf, Thierry.

Biomaterials for Stem Cell Therapy: State of Art and Vision for the Future. CRC Press/Balkema, 2013. p. 65-86.

Research output: Chapter in Book/Report/Conference proceedingChapter

Su, CY & Burnouf, T 2013, Blood-derived biomaterials: What role can they play in regenerative medicine and stem cell therapy? in Biomaterials for Stem Cell Therapy: State of Art and Vision for the Future. CRC Press/Balkema, pp. 65-86. https://doi.org/10.1201/b14584
Su CY, Burnouf T. Blood-derived biomaterials: What role can they play in regenerative medicine and stem cell therapy? In Biomaterials for Stem Cell Therapy: State of Art and Vision for the Future. CRC Press/Balkema. 2013. p. 65-86 https://doi.org/10.1201/b14584
Su, Chen Yao ; Burnouf, Thierry. / Blood-derived biomaterials : What role can they play in regenerative medicine and stem cell therapy?. Biomaterials for Stem Cell Therapy: State of Art and Vision for the Future. CRC Press/Balkema, 2013. pp. 65-86
@inbook{900e489c82b54bc8a219f28e9cdc62ac,
title = "Blood-derived biomaterials: What role can they play in regenerative medicine and stem cell therapy?",
abstract = "There is a growing clinical interest in regenerative medicine and stem cell therapies in the use of biomaterials made from human autologous (or allogeneic) blood because these products do not induce tissue reaction, are biodegradable and exhibit valuable physiological functions. The fi rst generation of blood-derived biomaterials called fi brin sealant, or fi brin glue, obtained by mixing a fi brinogen-rich fraction with thrombin were developed in the early 1900‘s and became available for routine clinical use in the 1980‘s in Europe and, later, in the USA (Radosevich et al. 1997, Jackson et al. 1996, Martinowitz and Saltz 1996, Spotnitz 2001, Mintz et al. 2001, Spotnitz and Prabhu 2005, Burnouf et al. 2009). Those glue-like sealants exhibit hemostatic and sealing properties. Both industrial and single-donor 1Department of Dentistry, National Yang-Ming University, Taipei, Taiwan. Email: henrycysu@gmail.com 2College of Oral Medicine, Taipei Medical University, Taipei, Taiwan & Human Protein Process Sciences (HPPS), Lille, France. &z.ast;Corresponding author fi brin sealants are currently available for use in many fi elds such as cardiac, plastic, oral, orthopedic, aesthetic, and implant surgeries (Radosevich et al. 1997, Burnouf et al. 2009). A second group of blood-derived biomaterials, called platelet gels (PLT gels), encompasses different types of products, depending upon their mode of preparation (Jackson et al. 1996, Burnouf et al. 2009, Everts et al. 2006a, Borzini and Mazzuco 2005, Marx 2001, Marx 2004). These are single-donor (usually autologous, more rarely allogenic) products obtained by combining platelet-rich plasma (PRP) with thrombin. The mixing of both fractions results in (a) the conversion of fi brinogen into fi brin, (b) the activation of platelets and (c) the release of a myriad of growth factors (GF) stored in the platelet a-granules (Blair and Flaumenhaft 2009). Upon activation by exogenous or endogenous agonists, platelets release a myriad of functional molecules which play a key role in tissue repair and regeneration by stimulation and differentiation of local stem cells (Marx et al. 1998). Among these are the numerous growth factors entrapped within alpha-granules: platelet-derived growth factors (PDGF) -AA, -BB, or -AB, transforming growth factor-(TGF- and -2), vascular endothelium growth factor (VEGF), epidermal growth factor (EGF), fi broblast growth factor-1 (FGF-1), brain-derived neurotrophic factor (BDNF), etc. Human platelet growth factors are now explored and proven to be unique non-toxic biocompatible tools for tissue engineering, stem cell expansion in vitro and cell therapy. GF-rich biomaterials, combined, or not, with fi brin glue, can be used as matrix for cell cultures (chondrocytes, keratinocytes, etc.) prior to implant. They can also be used as cell carriers for in vivo delivery to damaged tissues, e.g., for the healing of soft and hard tissues. Understandably, human platelet lysates rich in growth factors and other bioactive molecules are increasingly used successfully as a medium supplement to replace fetal bovine serum for the expansion of mesenchymal stem cells from various origins, opening new perspectives for the clinical development of stem cellbased cell therapy (Kazemnejad et al. 2008, Doucet et al. 2005, Vogel et al. 2006, Schallmoser and Strunk 2009, Kocaoemer et al. 2007, Shih et al. 2011). In this chapter, we present the four main categories of biomaterials made from human blood and their specifi city in biochemical and physiological properties as well as their clinical applications in particular in the fi eld of regenerative medicine and cell therapy. The main characteristics of these four biomaterials are summarized in Table 3.1.",
author = "Su, {Chen Yao} and Thierry Burnouf",
year = "2013",
month = "1",
day = "1",
doi = "10.1201/b14584",
language = "English",
isbn = "9781466576391",
pages = "65--86",
booktitle = "Biomaterials for Stem Cell Therapy",
publisher = "CRC Press/Balkema",

}

TY - CHAP

T1 - Blood-derived biomaterials

T2 - What role can they play in regenerative medicine and stem cell therapy?

AU - Su, Chen Yao

AU - Burnouf, Thierry

PY - 2013/1/1

Y1 - 2013/1/1

N2 - There is a growing clinical interest in regenerative medicine and stem cell therapies in the use of biomaterials made from human autologous (or allogeneic) blood because these products do not induce tissue reaction, are biodegradable and exhibit valuable physiological functions. The fi rst generation of blood-derived biomaterials called fi brin sealant, or fi brin glue, obtained by mixing a fi brinogen-rich fraction with thrombin were developed in the early 1900‘s and became available for routine clinical use in the 1980‘s in Europe and, later, in the USA (Radosevich et al. 1997, Jackson et al. 1996, Martinowitz and Saltz 1996, Spotnitz 2001, Mintz et al. 2001, Spotnitz and Prabhu 2005, Burnouf et al. 2009). Those glue-like sealants exhibit hemostatic and sealing properties. Both industrial and single-donor 1Department of Dentistry, National Yang-Ming University, Taipei, Taiwan. Email: henrycysu@gmail.com 2College of Oral Medicine, Taipei Medical University, Taipei, Taiwan & Human Protein Process Sciences (HPPS), Lille, France. &z.ast;Corresponding author fi brin sealants are currently available for use in many fi elds such as cardiac, plastic, oral, orthopedic, aesthetic, and implant surgeries (Radosevich et al. 1997, Burnouf et al. 2009). A second group of blood-derived biomaterials, called platelet gels (PLT gels), encompasses different types of products, depending upon their mode of preparation (Jackson et al. 1996, Burnouf et al. 2009, Everts et al. 2006a, Borzini and Mazzuco 2005, Marx 2001, Marx 2004). These are single-donor (usually autologous, more rarely allogenic) products obtained by combining platelet-rich plasma (PRP) with thrombin. The mixing of both fractions results in (a) the conversion of fi brinogen into fi brin, (b) the activation of platelets and (c) the release of a myriad of growth factors (GF) stored in the platelet a-granules (Blair and Flaumenhaft 2009). Upon activation by exogenous or endogenous agonists, platelets release a myriad of functional molecules which play a key role in tissue repair and regeneration by stimulation and differentiation of local stem cells (Marx et al. 1998). Among these are the numerous growth factors entrapped within alpha-granules: platelet-derived growth factors (PDGF) -AA, -BB, or -AB, transforming growth factor-(TGF- and -2), vascular endothelium growth factor (VEGF), epidermal growth factor (EGF), fi broblast growth factor-1 (FGF-1), brain-derived neurotrophic factor (BDNF), etc. Human platelet growth factors are now explored and proven to be unique non-toxic biocompatible tools for tissue engineering, stem cell expansion in vitro and cell therapy. GF-rich biomaterials, combined, or not, with fi brin glue, can be used as matrix for cell cultures (chondrocytes, keratinocytes, etc.) prior to implant. They can also be used as cell carriers for in vivo delivery to damaged tissues, e.g., for the healing of soft and hard tissues. Understandably, human platelet lysates rich in growth factors and other bioactive molecules are increasingly used successfully as a medium supplement to replace fetal bovine serum for the expansion of mesenchymal stem cells from various origins, opening new perspectives for the clinical development of stem cellbased cell therapy (Kazemnejad et al. 2008, Doucet et al. 2005, Vogel et al. 2006, Schallmoser and Strunk 2009, Kocaoemer et al. 2007, Shih et al. 2011). In this chapter, we present the four main categories of biomaterials made from human blood and their specifi city in biochemical and physiological properties as well as their clinical applications in particular in the fi eld of regenerative medicine and cell therapy. The main characteristics of these four biomaterials are summarized in Table 3.1.

AB - There is a growing clinical interest in regenerative medicine and stem cell therapies in the use of biomaterials made from human autologous (or allogeneic) blood because these products do not induce tissue reaction, are biodegradable and exhibit valuable physiological functions. The fi rst generation of blood-derived biomaterials called fi brin sealant, or fi brin glue, obtained by mixing a fi brinogen-rich fraction with thrombin were developed in the early 1900‘s and became available for routine clinical use in the 1980‘s in Europe and, later, in the USA (Radosevich et al. 1997, Jackson et al. 1996, Martinowitz and Saltz 1996, Spotnitz 2001, Mintz et al. 2001, Spotnitz and Prabhu 2005, Burnouf et al. 2009). Those glue-like sealants exhibit hemostatic and sealing properties. Both industrial and single-donor 1Department of Dentistry, National Yang-Ming University, Taipei, Taiwan. Email: henrycysu@gmail.com 2College of Oral Medicine, Taipei Medical University, Taipei, Taiwan & Human Protein Process Sciences (HPPS), Lille, France. &z.ast;Corresponding author fi brin sealants are currently available for use in many fi elds such as cardiac, plastic, oral, orthopedic, aesthetic, and implant surgeries (Radosevich et al. 1997, Burnouf et al. 2009). A second group of blood-derived biomaterials, called platelet gels (PLT gels), encompasses different types of products, depending upon their mode of preparation (Jackson et al. 1996, Burnouf et al. 2009, Everts et al. 2006a, Borzini and Mazzuco 2005, Marx 2001, Marx 2004). These are single-donor (usually autologous, more rarely allogenic) products obtained by combining platelet-rich plasma (PRP) with thrombin. The mixing of both fractions results in (a) the conversion of fi brinogen into fi brin, (b) the activation of platelets and (c) the release of a myriad of growth factors (GF) stored in the platelet a-granules (Blair and Flaumenhaft 2009). Upon activation by exogenous or endogenous agonists, platelets release a myriad of functional molecules which play a key role in tissue repair and regeneration by stimulation and differentiation of local stem cells (Marx et al. 1998). Among these are the numerous growth factors entrapped within alpha-granules: platelet-derived growth factors (PDGF) -AA, -BB, or -AB, transforming growth factor-(TGF- and -2), vascular endothelium growth factor (VEGF), epidermal growth factor (EGF), fi broblast growth factor-1 (FGF-1), brain-derived neurotrophic factor (BDNF), etc. Human platelet growth factors are now explored and proven to be unique non-toxic biocompatible tools for tissue engineering, stem cell expansion in vitro and cell therapy. GF-rich biomaterials, combined, or not, with fi brin glue, can be used as matrix for cell cultures (chondrocytes, keratinocytes, etc.) prior to implant. They can also be used as cell carriers for in vivo delivery to damaged tissues, e.g., for the healing of soft and hard tissues. Understandably, human platelet lysates rich in growth factors and other bioactive molecules are increasingly used successfully as a medium supplement to replace fetal bovine serum for the expansion of mesenchymal stem cells from various origins, opening new perspectives for the clinical development of stem cellbased cell therapy (Kazemnejad et al. 2008, Doucet et al. 2005, Vogel et al. 2006, Schallmoser and Strunk 2009, Kocaoemer et al. 2007, Shih et al. 2011). In this chapter, we present the four main categories of biomaterials made from human blood and their specifi city in biochemical and physiological properties as well as their clinical applications in particular in the fi eld of regenerative medicine and cell therapy. The main characteristics of these four biomaterials are summarized in Table 3.1.

UR - http://www.scopus.com/inward/record.url?scp=85060228237&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85060228237&partnerID=8YFLogxK

U2 - 10.1201/b14584

DO - 10.1201/b14584

M3 - Chapter

SN - 9781466576391

SP - 65

EP - 86

BT - Biomaterials for Stem Cell Therapy

PB - CRC Press/Balkema

ER -