Blood copper and zinc levels and copper-related antioxidant enzyme activities in hypercholesterolemic subjects

Xue Ping Hu, Chang Yun Hsu, Ming Che Hsieh

Research output: Contribution to journalArticle

Abstract

Hypercholesterolemia has been shown to be a consequence of dietary copper (Cu) deficiency in experimental animals. There are several biochemical changes induced by Cu deficiency. We examined the lipid level, superoxide dismutase (SOD), glutathione peroxidase (GSHPx), ceruloplasmin (Cp) and plasma Cu and Zn levels in hypercholesterolemic subjects (N=23, total cholesterol (TC)≤ 240 mg/dL); borderline hypercholesterolemic subjects (N=31, 200 ≤ TC <240 mg/dL) and control subjects (N=25, TC <200 mg/dL). Total cholesterol, triglyceride (TG), and low density lipoprotein (LDL-C) levels were higher in hypercholesterolemic subjects than in the normal subjects (p <0.05). Hypercholesterolemic subjects had lower Cu levels than the control subjects (p <0.05). The SOD, Cp, and Zn levels in the hypercholesterolemic subjects did not significantly differ from those in the control group. Lipid levels were not related to plasma Cu, SOD, and Cp among the three groups. Plasma GSHPx levels were positively correlated with SOD and Cp values in the control subjects (r= 0.40, r=0.45, p

Original languageEnglish
Pages (from-to)277-285
Number of pages9
JournalNutritional Sciences Journal
Volume22
Issue number3
Publication statusPublished - 1997

Fingerprint

ferroxidase
Ceruloplasmin
Superoxide Dismutase
Zinc
Copper
superoxide dismutase
Antioxidants
copper
zinc
cholesterol
enzyme activity
antioxidants
Cholesterol
blood
Enzymes
Lipids
hypercholesterolemia
low density lipoprotein
lipids
Glutathione Peroxidase

Keywords

  • Ceruloplasmin
  • Copper
  • GSHPx
  • Hypercholesterolemia
  • SOD
  • Zinc

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Blood copper and zinc levels and copper-related antioxidant enzyme activities in hypercholesterolemic subjects. / Hu, Xue Ping; Hsu, Chang Yun; Hsieh, Ming Che.

In: Nutritional Sciences Journal, Vol. 22, No. 3, 1997, p. 277-285.

Research output: Contribution to journalArticle

Hu, Xue Ping ; Hsu, Chang Yun ; Hsieh, Ming Che. / Blood copper and zinc levels and copper-related antioxidant enzyme activities in hypercholesterolemic subjects. In: Nutritional Sciences Journal. 1997 ; Vol. 22, No. 3. pp. 277-285.
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