Blockade of isoproterenol-induced synaptic potentiation by tetra-9-aminoacridine in the rat amygdala

Su Jane Wang, Chiung Chun Huang, Kuei Sen Hsu, Jing Jane Tsai, Chao Ching Huang, Po Wu Gean

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The effects of tetrahydro-9-aminoacridine (THA) on β-adrenoceptor activation-induced synaptic potentiation were studied in brain slices of the rat amygdala using intracellular recording techniques. To exclude the involvement of N-methyl-D-aspartate (NMDA) receptors, all the experiments were performed in the presence of NMDA receptor antagonist, D-APV (50 μM). Bath application of isoproterenol (Iso; 15 μM) results in a long-lasting enhancement of the amplitude of excitatory postsynaptic potentials (EPSPs) to 200 ± 6% of baseline. Forskolin, which directly activates adenyl cyclase, produces a similar effect suggesting that Iso may act through a cyclic AMP-dependent mechanism. Pretreatment of the slices with THA (300 μM) completely abolishes the Iso- and forskolin-induced synaptic potentiation. We hypothesize that the locus of THA/β-adrenoceptor interaction is presynaptic; the underlying mechanism is likely due to THA's depression of transmitter release via a presynaptic blockade of voltage-dependent Ca2+ channels.

Original languageEnglish
Pages (from-to)87-90
Number of pages4
JournalNeuroscience Letters
Volume214
Issue number2-3
DOIs
Publication statusPublished - Aug 23 1996
Externally publishedYes

Fingerprint

Aminacrine
Amygdala
Isoproterenol
Colforsin
N-Methyl-D-Aspartate Receptors
Adrenergic Receptors
Tacrine
Excitatory Postsynaptic Potentials
Baths
Adenylyl Cyclases
Cyclic AMP
Brain

Keywords

  • Amygdala
  • Forskolin
  • Isoproterenol
  • Long-term potentiation
  • Tetrahydro-9-aminoacridine

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Blockade of isoproterenol-induced synaptic potentiation by tetra-9-aminoacridine in the rat amygdala. / Wang, Su Jane; Huang, Chiung Chun; Hsu, Kuei Sen; Tsai, Jing Jane; Huang, Chao Ching; Gean, Po Wu.

In: Neuroscience Letters, Vol. 214, No. 2-3, 23.08.1996, p. 87-90.

Research output: Contribution to journalArticle

Wang, Su Jane ; Huang, Chiung Chun ; Hsu, Kuei Sen ; Tsai, Jing Jane ; Huang, Chao Ching ; Gean, Po Wu. / Blockade of isoproterenol-induced synaptic potentiation by tetra-9-aminoacridine in the rat amygdala. In: Neuroscience Letters. 1996 ; Vol. 214, No. 2-3. pp. 87-90.
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