Blockade of isoproterenol-induced synaptic potentiation by tetra-9-aminoacridine in the rat amygdala

Su Jane Wang, Chiung Chun Huang, Kuei Sen Hsu, Jing Jane Tsai, Chao Ching Huang, Po Wu Gean

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The effects of tetrahydro-9-aminoacridine (THA) on β-adrenoceptor activation-induced synaptic potentiation were studied in brain slices of the rat amygdala using intracellular recording techniques. To exclude the involvement of N-methyl-D-aspartate (NMDA) receptors, all the experiments were performed in the presence of NMDA receptor antagonist, D-APV (50 μM). Bath application of isoproterenol (Iso; 15 μM) results in a long-lasting enhancement of the amplitude of excitatory postsynaptic potentials (EPSPs) to 200 ± 6% of baseline. Forskolin, which directly activates adenyl cyclase, produces a similar effect suggesting that Iso may act through a cyclic AMP-dependent mechanism. Pretreatment of the slices with THA (300 μM) completely abolishes the Iso- and forskolin-induced synaptic potentiation. We hypothesize that the locus of THA/β-adrenoceptor interaction is presynaptic; the underlying mechanism is likely due to THA's depression of transmitter release via a presynaptic blockade of voltage-dependent Ca2+ channels.

Original languageEnglish
Pages (from-to)87-90
Number of pages4
JournalNeuroscience Letters
Volume214
Issue number2-3
DOIs
Publication statusPublished - Aug 23 1996
Externally publishedYes

Keywords

  • Amygdala
  • Forskolin
  • Isoproterenol
  • Long-term potentiation
  • Tetrahydro-9-aminoacridine

ASJC Scopus subject areas

  • Neuroscience(all)

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